Robin Meier
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View article: Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing
Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing Open
The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process. Compared with…
View article: A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants
A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants Open
Dry granulation via roller compaction is increasingly being used as granulation method for the production of oral solid dosage forms. Advantages of roller compaction include a simplified process compared to wet granulation and the inherent…
View article: Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A
Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A Open
PIP4K2A is an insufficiently studied type II lipid kinase that catalyzes the conversion of phosphatidylinositol-5-phosphate (PI5P) into phosphatidylinositol 4,5-bisphosphate (PI4,5P2). The involvement of PIP4K2A/B in cancer has been sugges…
View article: Grey-Box Approach for the Prediction of Variable Residence Time Distribution in Continuous Pharmaceutical Manufacturing
Grey-Box Approach for the Prediction of Variable Residence Time Distribution in Continuous Pharmaceutical Manufacturing Open
Axial dispersion models are used for the prediction of residence time distribution (RTD) of the flow occurring in various processes. Such models are essential for the understanding of the flow dynamics allowing monitoring, control and mate…