Robin E. Muller
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View article: Automated Mission Management of Small Unmanned Aircraft Systems for Critical Events in Urban Air Traffic
Automated Mission Management of Small Unmanned Aircraft Systems for Critical Events in Urban Air Traffic Open
Unmanned aerial systems (UAS) have a great potential to benefit society. This has already been shown in many use-cases. Nevertheless the true potential lies in the upscaling of operations. Therefore a high automation level and ensured safe…
View article: Walking bumblebees see faster
Walking bumblebees see faster Open
The behavioural state of animals has profound effects on neuronal information processing. Locomotion changes the response properties of visual interneurons in the insect brain, but it is still unknown if it also alters the response propert…
View article: Walking bumblebees see faster
Walking bumblebees see faster Open
The behavioral state of an animal has profound effects on neuronal information processing. Locomotion changes the response properties of visual interneurons in the insect brain, but it is still unknown if it also alters the response proper…
View article: Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis
Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis Open
G-protein signaling pathways, as key components of physiologic responsiveness and timing, are frequent targets for pharmacologic intervention. Here, we identify an effector for heterotrimeric G-protein α subunit (EhGα1) signaling from Enta…
View article: Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein α Subunit Mutants
Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein α Subunit Mutants Open
GoLoco motif proteins bind to the inhibitory Gi subclass of G-protein α subunits and slow the release of bound GDP; this interaction is considered critical to asymmetric cell division and neuro-epithelium and epithelial progenitor differen…
View article: Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica
Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica Open
Heterotrimeric G-protein signaling pathways are vital components of physiology, and many are amenable to pharmacologic manipulation. Here, we identify functional heterotrimeric G-protein subunits in Entamoeba histolytica, the causative age…
View article: A High Throughput Fluorescence Polarization Assay for Inhibitors of the GoLoco Motif/G-alpha Interaction
A High Throughput Fluorescence Polarization Assay for Inhibitors of the GoLoco Motif/G-alpha Interaction Open
The GoLoco motif is a short Gα-binding polypeptide sequence. It is often found in proteins that regulate cell-surface receptor signaling, such as RGS12, as well as in proteins that regulate mitotic spindle orientation and force generation …
View article: A Homogeneous Method to Measure Nucleotide Exchange by α-Subunits of Heterotrimeric G-Proteins Using Fluorescence Polarization
A Homogeneous Method to Measure Nucleotide Exchange by α-Subunits of Heterotrimeric G-Proteins Using Fluorescence Polarization Open
The mainstay of assessing guanosine diphosphate release by the α-subunit of a heterotrimeric G-protein is the [35S]guanosine 5′-O-(3-thiotriphosphate) (GTPγS) radionucleotide-binding assay. This assay requires separation of protein-bound G…
View article: Inflammatory Response of Monocytes to Ambient Particles Varies by Highway Proximity
Inflammatory Response of Monocytes to Ambient Particles Varies by Highway Proximity Open
Epidemiological studies have demonstrated associations of chronic respiratory disease with near-roadway pollutant exposure, effects that were independent of those of regional air pollutants. However, there has been limited study of the pot…
View article: Toward CO2 and CH4 measurements by ground-based observations of surface-scattered sunlight: Instrumentation and experiments
Toward CO2 and CH4 measurements by ground-based observations of surface-scattered sunlight: Instrumentation and experiments Open
<div> <div>Precise knowledge of sources and sinks in the carbon cycle is desired to understand its sensitivity to climate change, and to account and verify man-made emissions. An important role herein play extended sources like…