Robin E. Pearce
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View article: Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation
Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation Open
Metronidazole is commonly used to treat intra-abdominal infections in neonates.1,2 The parent drug is converted to 5 metabolites, with 2-hydroxy-metronidazole being the most clinically significant, as it possesses 30–65% of the antimicrobi…
View article: Influence of novel <scp>CYP2C‐haplotype</scp> on proton pump inhibitor pharmacokinetics in children
Influence of novel <span>CYP2C‐haplotype</span> on proton pump inhibitor pharmacokinetics in children Open
In this brief report, we provide an analysis of the influence of a novel CYP2C haplotype ( CYP2C:TG ) on proton pump inhibitor (PPI) pharmacokinetics (PK) in children. The CYP2C:TG haplotype has been proposed to be associated with increase…
Combination Treatment of Withalongolide a Triacetate with Cisplatin Induces Apoptosis by Targeting Translational Initiation, Migration, and Epithelial to Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma Open
Treatment regimens for head and neck squamous cell carcinoma (HNSCC) typically include cisplatin and radiotherapy and are limited by toxicities. We have identified naturally derived withalongolide A triacetate (WGA-TA) from Physalis longif…
View article: A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence
A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence Open
CYP2D6 substrates are among the most highly prescribed medications in teenagers and also commonly associated with serious adverse events. To investigate the relative contributions of genetic variation, growth, and development on CYP2D6 act…
View article: Utility of the <sup>13</sup>C‐pantoprazole breath test as a CYP2C19 phenotyping probe for children
Utility of the <sup>13</sup>C‐pantoprazole breath test as a CYP2C19 phenotyping probe for children Open
The 13 C‐pantoprazole breath test (PAN‐BT) is a safe, noninvasive, in vivo CYP2C19 phenotyping probe for adults. Our objective was to evaluate PAN‐BT performance in children, with a focus on discriminating individuals who, according to gui…
View article: The Impact of the CYP2D6 “Enhancer” Single Nucleotide Polymorphism on CYP2D6 Activity
The Impact of the CYP2D6 “Enhancer” Single Nucleotide Polymorphism on CYP2D6 Activity Open
rs5758550 has been associated with enhanced transcription and suggested to be a useful marker of CYP2D6 activity. As there are limited and inconsistent data regarding the utility of this distant “enhancer” single nucleotide polymorphism (S…
Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults Open
Aims CYP2A6 is a genetically polymorphic enzyme resulting in differential substrate metabolism and health behaviours. Current phenotyping probes for CYP2A6 exhibit limitations related to procurement (deuterated cotinine), toxicity (coumari…
Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity Open
Summary Background Children with obesity are more likely to suffer gastroesophageal reflux disease, requiring acid‐suppression therapy with proton pump inhibitors (PPIs) and no guidelines regarding dosing. Objective To prospectively evalua…
Variants in the<i>CYP2B6</i>3′UTR Alter<i>In Vitro</i>and<i>In Vivo</i>CYP2B6 Activity: Potential Role of MicroRNAs Open
CYP2B6*6 and CYP2B6*18 are the most clinically important variants causing reduced CYP2B6 protein expression and activity. However, these variants do not account for all variability in CYP2B6 activity. Emerging evidence has shown that genet…
View article: Issue Information
Issue Information Open
Aims and Scope: For more than 50 years, clinical pharmacologists, clinical and pharmaceutical researchers, drug development specialists, physicians, nurses, and other medical professionals have relied on The Journal of Clinical Pharmacolog…