Robin Skuce
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View article: Evaluation of Mycobacterial Load Assay for rapid molecular identification of Mycobacterium bovis in bovine tissues
Evaluation of Mycobacterial Load Assay for rapid molecular identification of Mycobacterium bovis in bovine tissues Open
Mammalian tuberculosis (TB) in cattle, caused mostly by Mycobacterium bovis, has a significant impact on veterinary public health, animal welfare, trade, and farming economies. Diagnosis and laboratory confirmation are crucial for disease …
View article: Assessing the potential role of deer in the dissemination of Mycobacterium bovis infection to cattle in Northern Ireland
Assessing the potential role of deer in the dissemination of Mycobacterium bovis infection to cattle in Northern Ireland Open
Mycobacterium bovis, the causative agent of animal tuberculosis, exhibits a broad host range - infecting, inducing pathology and transmitting from both bovine and wildlife hosts. Considerable effort has been extended to understanding the r…
View article: Whole-Genome sequencing in routine Mycobacterium bovis epidemiology – scoping the potential
Whole-Genome sequencing in routine Mycobacterium bovis epidemiology – scoping the potential Open
Mycobacterium bovis the main agent of bovine tuberculosis (bTB), presents as a series of spatially-localised micro-epidemics across landscapes. Classical molecular typing methods applied to these micro-epidemics, based on genotyping a few …
View article: Genomic epidemiology of Mycobacterium bovis infection in sympatric badger and cattle populations in Northern Ireland
Genomic epidemiology of Mycobacterium bovis infection in sympatric badger and cattle populations in Northern Ireland Open
Bovine tuberculosis (bTB) is a costly, epidemiologically complex, multi-host, endemic disease. Lack of understanding of transmission dynamics may undermine eradication efforts. Pathogen whole-genome sequencing improves epidemiological infe…
View article: Seroprevalence of Mycobacterium avium subsp. paratuberculosis (MAP) and associated risk factors in Northern Ireland dairy cattle herds
Seroprevalence of Mycobacterium avium subsp. paratuberculosis (MAP) and associated risk factors in Northern Ireland dairy cattle herds Open
Background Johne’s disease is a chronic granulomatous enteritis of cattle and other ruminants of economic, animal and public health significance, caused by Mycobacterium avium subsp. paratuberculosis . It is endemic in UK, but there is cur…
View article: European badger ( <i>Meles meles</i> ) responses to low‐intensity, selective culling: Using mark–recapture and relatedness data to assess social perturbation
European badger ( <i>Meles meles</i> ) responses to low‐intensity, selective culling: Using mark–recapture and relatedness data to assess social perturbation Open
Culling the main wildlife host of bovine tuberculosis in Great Britain (GB) and Ireland, the European badger ( Meles meles ), has been employed in both territories to reduce infections in cattle. In GB, this has been controversial, with re…
View article: Evidence for local and international spread of Mycobacterium avium subspecies paratuberculosis through whole genome sequencing of isolates from the island of Ireland
Evidence for local and international spread of Mycobacterium avium subspecies paratuberculosis through whole genome sequencing of isolates from the island of Ireland Open
We describe application of whole genome sequencing (WGS) to a collection of 197 Mycobacterium avium subsp paratuberculosis (MAP) isolates gathered from 122 cattle herds across 27 counties of the island of Ireland. We compare WGS to MAP div…
View article: Phylodynamic analysis of an emergent <i>Mycobacterium bovis</i> outbreak in an area with no previously known wildlife infections
Phylodynamic analysis of an emergent <i>Mycobacterium bovis</i> outbreak in an area with no previously known wildlife infections Open
Understanding how emergent pathogens successfully establish themselves and persist in previously unaffected populations is a crucial problem in disease ecology, with important implications for disease management. In multi‐host pathogen sys…
View article: A new phylodynamic model of Mycobacterium bovis transmission in a multi-host system uncovers the role of the unobserved reservoir
A new phylodynamic model of Mycobacterium bovis transmission in a multi-host system uncovers the role of the unobserved reservoir Open
Multi-host pathogens are particularly difficult to control, especially when at least one of the hosts acts as a hidden reservoir. Deep sequencing of densely sampled pathogens has the potential to transform this understanding, but requires …
View article: A new phylodynamic model of<i>Mycobacterium bovis</i>transmission in a multi-host system uncovers the role of the unobserved reservoir
A new phylodynamic model of<i>Mycobacterium bovis</i>transmission in a multi-host system uncovers the role of the unobserved reservoir Open
Multi-host pathogens are particularly difficult to control, especially when at least one of the hosts acts as a hidden reservoir. Deep sequencing of densely sampled pathogens has the potential to transform this understanding, but requires …
View article: Genomic epidemiology of<i>Mycobacterium bovis</i>infection in sympatric badger and cattle populations in Northern Ireland
Genomic epidemiology of<i>Mycobacterium bovis</i>infection in sympatric badger and cattle populations in Northern Ireland Open
Background Bovine tuberculosis (bTB) is a costly, epidemiologically complex, multi-host, endemic disease. Pathogen whole genome sequencing can improve the resolution of epidemiological tracing. We genome sequenced an exceptional data set o…
View article: Development of polymorphic markers in the immune gene complex loci of cattle
Development of polymorphic markers in the immune gene complex loci of cattle Open
The addition of cattle health and immunity traits to genomic selection indices holds promise to increase individual animal longevity and productivity, and decrease economic losses from disease. However, highly variable genomic loci that co…
View article: Does Mycobacterium tuberculosis var. bovis Survival in the Environment Confound Bovine Tuberculosis Control and Eradication? A Literature Review
Does Mycobacterium tuberculosis var. bovis Survival in the Environment Confound Bovine Tuberculosis Control and Eradication? A Literature Review Open
Bovine tuberculosis (bTB) is one of the globe’s most common, multihost zoonoses and results in substantial socioeconomic costs for governments, farming industries, and tax payers. Despite decades of surveillance and research, surprisingly,…
View article: Phylodynamic analysis of an emergent<i>Mycobacterium bovis</i>outbreak in an area with no previously known wildlife infections
Phylodynamic analysis of an emergent<i>Mycobacterium bovis</i>outbreak in an area with no previously known wildlife infections Open
Understanding how an emergent pathogen successfully establishes itself and persists in a previously unaffected population is a crucial problem in disease ecology. In multi-host pathogen systems this problem is particularly difficult, as th…
View article: Mycobacterium bovis Population Structure in Cattle and Local Badgers: Co-Localisation and Variation by Farm Type
Mycobacterium bovis Population Structure in Cattle and Local Badgers: Co-Localisation and Variation by Farm Type Open
Bovine tuberculosis surveillance in Northern Ireland includes Multiple-Locus Variable number tandem repeat Analysis (MLVA) to determine the Mycobacterium bovis genetic type present in both cattle and the predominant wildlife host, the Euro…
View article: <em>Mycobacterium bovis</em> Population Structure in Cattle and Local Badgers: Co-localisation and Variation by Farm Type
<em>Mycobacterium bovis</em> Population Structure in Cattle and Local Badgers: Co-localisation and Variation by Farm Type Open
Bovine tuberculosis surveillance in Northern Ireland includes Multiple-Locus Variable number tandem repeat Analysis (MLVA) to determine the Mycobacterium bovis genetic type present in both cattle, and the predominant wildlife host, the Eur…
View article: Genetic evidence further elucidates the history and extent of badger introductions from Great Britain into Ireland
Genetic evidence further elucidates the history and extent of badger introductions from Great Britain into Ireland Open
The colonization of Ireland by mammals has been the subject of extensive study using genetic methods and forms a central problem in understanding the phylogeography of European mammals after the Last Glacial Maximum. Ireland exhibits a dep…
View article: Bovine tuberculosis breakdown duration in cattle herds: an investigation of herd, host, pathogen and wildlife risk factors
Bovine tuberculosis breakdown duration in cattle herds: an investigation of herd, host, pathogen and wildlife risk factors Open
Background Despite rigorous controls placed on herds which disclose ante-mortem test positive cattle to bovine tuberculosis, caused by the infection of Mycobacterium bovis , many herds in Northern Ireland (NI) experience prolonged breakdow…
View article: Peer Review #1 of "Bovine tuberculosis breakdown duration in cattle herds: an investigation of herd, host, pathogen and wildlife risk factors (v0.1)"
Peer Review #1 of "Bovine tuberculosis breakdown duration in cattle herds: an investigation of herd, host, pathogen and wildlife risk factors (v0.1)" Open
Background.Despite rigorous controls placed on herds which disclose antemortem test positive cattle to bovine tuberculosis, caused by the infection of Mycobacterium bovis, many herds in Northern Ireland (NI) experience prolonged breakdowns…
View article: All microsatellite genotype and mitochondrial sequence data for British and Irish badgers from Genetic evidence further elucidates the history and extent of badger introductions from Great Britain into Ireland
All microsatellite genotype and mitochondrial sequence data for British and Irish badgers from Genetic evidence further elucidates the history and extent of badger introductions from Great Britain into Ireland Open
Supplementary Data 1
View article: Additional Figures relating to analyses described in results section of main text and supplementary materials from Genetic evidence further elucidates the history and extent of badger introductions from Great Britain into Ireland
Additional Figures relating to analyses described in results section of main text and supplementary materials from Genetic evidence further elucidates the history and extent of badger introductions from Great Britain into Ireland Open
Supplementary Figures
View article: Tables referred to in main text from Genetic evidence further elucidates the history and extent of badger introductions from Great Britain into Ireland
Tables referred to in main text from Genetic evidence further elucidates the history and extent of badger introductions from Great Britain into Ireland Open
Supplementary Tables
View article: Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system
Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system Open
Quantifying pathogen transmission in multi-host systems is difficult, as exemplified in bovine tuberculosis (bTB) systems, but is crucial for control. The agent of bTB, Mycobacterium bovis, persists in cattle populations worldwide, often w…
View article: Bovine tuberculosis breakdown duration in cattle herds: an investigation of herd, host, pathogen and wildlife risk factors
Bovine tuberculosis breakdown duration in cattle herds: an investigation of herd, host, pathogen and wildlife risk factors Open
Background. Despite rigorous controls placed on herds which disclose antemortem test positive cattle to bovine tuberculosis, caused by the infection of Mycobacterium bovis, many herds in Northern Ireland (NI) experience prolonged breakdown…
View article: Bovine tuberculosis breakdown duration in cattle herds: an investigation of herd, host, pathogen and wildlife risk factors
Bovine tuberculosis breakdown duration in cattle herds: an investigation of herd, host, pathogen and wildlife risk factors Open
Background. Despite rigorous controls placed on herds which disclose antemortem test positive cattle to bovine tuberculosis, caused by the infection of Mycobacterium bovis, many herds in Northern Ireland (NI) experience prolonged breakdown…
View article: Author response: Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system
Author response: Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Appendix 2 Data availability References Decision letter Author response Article and author information Metrics Abstract Quantif…
View article: Variation in Mycobacterium bovis genetic richness suggests that inwards cattle movements are a more important source of infection in beef herds than in dairy herds
Variation in Mycobacterium bovis genetic richness suggests that inwards cattle movements are a more important source of infection in beef herds than in dairy herds Open
The principal finding is that low MLVA genotype richness indicates that small-scale epidemics, e.g. wildlife, contiguous farms, and within-herd recrudescence, are important routes of M. bovis infection in cattle herds. We hypothesise that …
View article: Corrigendum: Bovine Tuberculosis in Britain and Ireland – A Perfect Storm? the Confluence of Potential Ecological and Epidemiological Impediments to Controlling a Chronic Infectious Disease
Corrigendum: Bovine Tuberculosis in Britain and Ireland – A Perfect Storm? the Confluence of Potential Ecological and Epidemiological Impediments to Controlling a Chronic Infectious Disease Open
[This corrects the article DOI: 10.3389/fvets.2018.00109.].
View article: Genome epidemiology of Mycobacterium bovis infection in contemporaneous, sympatric badger and cattle populations in Northern Ireland
Genome epidemiology of Mycobacterium bovis infection in contemporaneous, sympatric badger and cattle populations in Northern Ireland Open
Introduction Bovine tuberculosis (bTB) is an epidemiologically complex disease affecting both cattle and badgers in the UK and Ireland. Traditional molecular typing schemes have been used to characterise the spatial structure of the pathog…