Robin Stipp
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View article: Time-resolved structures of β<sub>2</sub>-adrenergic receptor modulation by a photoswitchable beta-blocker
Time-resolved structures of β<sub>2</sub>-adrenergic receptor modulation by a photoswitchable beta-blocker Open
G protein-coupled receptors (GPCRs) regulate essential physiological responses and are important drug targets, yet their ligand-induced conformational dynamics remain poorly understood. The β 2 -adrenergic receptor (β 2 AR) is a prominent …
View article: Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography
Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography Open
View article: Photochemical affinity switches to resolve ligand dissociation from a G protein-coupled receptor by time-resolved serial crystallography
Photochemical affinity switches to resolve ligand dissociation from a G protein-coupled receptor by time-resolved serial crystallography Open
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors in humans. The binding and dissociation of ligands tunes the inherent conformational flexibility of these important drug targets towards distinct function…
View article: Direct observation of coherent azobenzene photochemistry
Direct observation of coherent azobenzene photochemistry Open
Molecular photoswitches are versatile natural or synthetic molecules that undergo reversible conformational changes in response to light. In chemistry azobenzenes act as ubiquitous synthetic photoswitches1 with applications rang…
View article: A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers
A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers Open
Serial crystallography at X-ray free-electron lasers (XFELs) permits the determination of radiation-damage free static as well as time-resolved protein structures at room temperature. Efficient sample delivery is a key factor for such expe…
View article: A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers
A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers Open
Serial crystallography at X-ray free-electron lasers (XFELs) permits the determination of radiation-damage free static as well as time-resolved protein structures at room temperature. Efficient sample delivery is a key factor for such expe…
View article: Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography Open
View article: Release of a photopharmacological drug from its protein target captured by time-resolved serial crystallography
Release of a photopharmacological drug from its protein target captured by time-resolved serial crystallography Open
The binding and release of ligands from their protein targets is central to fundamental biological processes as well as to drug discovery. Photopharmacology introduces chemical triggers that allow the changing of ligand affinities and thus…
View article: Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography Open
The binding and release of ligands from their protein targets is central to fundamental biological processes as well as to drug discovery. Photopharmacology introduces chemical triggers that allow the changing of ligand affinities and thus…