Robin von Rotz
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View article: Population pharmacokinetic-pharmacodynamic modeling of co-administered N,N-dimethyltryptamine and harmine in healthy subjects
Population pharmacokinetic-pharmacodynamic modeling of co-administered N,N-dimethyltryptamine and harmine in healthy subjects Open
N,N-dimethyltryptamine (DMT) is a psychedelic compound commonly co-administered with the monoamine oxidase inhibitor harmine in ayahuasca-inspired formulations. However, the impact of harmine on DMT pharmacokinetics (PK) and pharmacodynami…
View article: Psilocybin-assisted therapy for relapse prevention in alcohol use disorder: a phase 2 randomized clinical trial
Psilocybin-assisted therapy for relapse prevention in alcohol use disorder: a phase 2 randomized clinical trial Open
View article: Examining the pharmacokinetic and pharmacodynamic interaction of N,N-dimethyltryptamine and harmine in healthy volunteers: Α factorial dose-escalation study
Examining the pharmacokinetic and pharmacodynamic interaction of N,N-dimethyltryptamine and harmine in healthy volunteers: Α factorial dose-escalation study Open
Ayahuasca, a traditional psychoactive Amazonian brew, usually contains N,N-dimethyltryptamine (DMT) and β-carboline (harmine, harmaline, tetrahydroharmine) monoamine oxidase inhibitors. However, the pharmacological interactions between the…
View article: Psilocybin increases emotional empathy in patients with major depression
Psilocybin increases emotional empathy in patients with major depression Open
View article: Potential therapeutic effects of an ayahuasca-inspired N,N-DMT and harmine formulation: a controlled trial in healthy subjects
Potential therapeutic effects of an ayahuasca-inspired N,N-DMT and harmine formulation: a controlled trial in healthy subjects Open
Background There is growing scientific evidence for the therapeutic benefits of the Amazonian plant-based psychedelic “ayahuasca” for neuropsychiatric disorders such as depression and anxiety. However, there are certain challenges when inc…
View article: Reshaping the emotional landscape: exploring psilocybin's effects on emotion regulation in depression
Reshaping the emotional landscape: exploring psilocybin's effects on emotion regulation in depression Open
View article: Associations between behavioral and neuronal changes in self-referential processing following a single, moderate dose of psilocybin in depressed patients
Associations between behavioral and neuronal changes in self-referential processing following a single, moderate dose of psilocybin in depressed patients Open
View article: Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine
Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine Open
Recently, the Amazonian plant medicine “ayahuasca”—containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such as harmine—has been suggested to exhibit beneficial effects in patients with affec…
View article: TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology
TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology Open
View article: Corrigendum to ‘Single-dose psilocybin-assisted therapy in major depressive disorder: a placebo-controlled, double-blind, randomised clinical trial’
Corrigendum to ‘Single-dose psilocybin-assisted therapy in major depressive disorder: a placebo-controlled, double-blind, randomised clinical trial’ Open
View article: Single-dose psilocybin-assisted therapy in major depressive disorder: a placebo-controlled, double-blind, randomised clinical trial
Single-dose psilocybin-assisted therapy in major depressive disorder: a placebo-controlled, double-blind, randomised clinical trial Open
View article: Effects of gamma-hydroxybutyrate on neurophysiological correlates of performance and conflict monitoring
Effects of gamma-hydroxybutyrate on neurophysiological correlates of performance and conflict monitoring Open
View article: Prohedonic properties of gamma‐hydroxybutyrate are associated with changes in limbic resting‐state functional connectivity
Prohedonic properties of gamma‐hydroxybutyrate are associated with changes in limbic resting‐state functional connectivity Open
Objective Gamma‐hydroxybutyrate (GHB) is an endogenous GHB‐/GABA‐B receptor agonist and a narcolepsy treatment. However, GHB is also abused for its prohedonic effects. On a neuronal level, it was shown that GHB increases regional cerebral …
View article: Gamma-hydroxybutyrate increases brain resting-state functional connectivity of the salience network and dorsal nexus in humans
Gamma-hydroxybutyrate increases brain resting-state functional connectivity of the salience network and dorsal nexus in humans Open
View article: Gamma-Hydroxybutyrate Increases Resting-State Limbic Perfusion and Body and Emotion Awareness in Humans
Gamma-Hydroxybutyrate Increases Resting-State Limbic Perfusion and Body and Emotion Awareness in Humans Open
View article: Neuronal oscillations and synchronicity associated with gamma-hydroxybutyrate during resting-state in healthy male volunteers
Neuronal oscillations and synchronicity associated with gamma-hydroxybutyrate during resting-state in healthy male volunteers Open
View article: Alpha oscillations underlie working memory abnormalities in the psychosis high-risk state
Alpha oscillations underlie working memory abnormalities in the psychosis high-risk state Open
View article: Neural underpinnings of prosexual effects induced by gamma-hydroxybutyrate in healthy male humans
Neural underpinnings of prosexual effects induced by gamma-hydroxybutyrate in healthy male humans Open
Gamma-hydroxybutyrate (GHB) is a GHB-/GABAB-receptor agonist currently used as treatment for narcolepsy but also as a drug of abuse. Non-medical GHB users have repeatedly reported prosexual effects including libido-enhancement a…
View article: Pharmacokinetics and pharmacodynamics of γ‐hydroxybutyrate in healthy subjects
Pharmacokinetics and pharmacodynamics of γ‐hydroxybutyrate in healthy subjects Open
Aims γ‐Hydroxybutyrate (GHB) is used as a treatment for narcolepsy and alcohol withdrawal and as a recreational substance. Nevertheless, there are limited data on the pharmacokinetics and pharmacokinetic‐pharmacodynamic relationships of GH…
View article: Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone
Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone Open