Explanipedia

Steric repulsion counteracts ER–to–lipid droplet protein movement Open

Alicia Damm, Mohyeddine Omrane, Ozren Stojanović, Bianca M. Esch, Mehdi Zouiouich , et al. · 2025

Lipid droplets (LDs) are organelles with a neutral lipid core surrounded by a phospholipid monolayer, which is continuous with the cytoplasmic leaflet of the endoplasmic reticulum (ER). LD function depends on a highly dynamic LD surface pr…

Steric Repulsion Counteracts ER-to-Lipid Droplet Protein Movement Open

Alicia Damm, Ozren Stojanović, Bianca M. Esch, Maxime Carpentier, Mohyeddine Omrane , et al. · 2024

Lipid droplets (LDs) are uniquely shaped organelles consisting of a neutral lipid core surrounded by a phospholipid monolayer, continuous with the cytosolic leaflet of the endoplasmic reticulum (ER). The dynamics and function of LDs are cl…

Lipid Droplets Big and Small: Basic Mechanisms That Make Them All Open

Robin W. Klemm, Pedro Carvalho · 2024

Lipid droplets (LDs) are dynamic storage organelles with central roles in lipid and energy metabolism. They consist of a core of neutral lipids, such as triacylglycerol, which is surrounded by a monolayer of phospholipids and specialized s…

Perilipin membrane integration determines lipid droplet heterogeneity in differentiating adipocytes Open

Mario Majchrzak, Ozren Stojanović, Dalila Ajjaji, Kalthoum Ben M’Barek, Mohyeddine Omrane , et al. · 2024

The storage of fat within lipid droplets (LDs) of adipocytes is critical for whole-body health. Acute fatty acid (FA) uptake by differentiating adipocytes leads to the formation of at least two LD classes marked by distinct perilipins (PLI…

Remodelling of mitochondrial function by import of specific lipids at multiple membrane‐contact sites Open

Aksel J. Saukko‐Paavola, Robin W. Klemm · 2024

Organelles form physical and functional contact between each other to exchange information, metabolic intermediates, and signaling molecules. Tethering factors and contact site complexes bring partnering organelles into close spatial proxi…

Perilipin membrane-integration determines lipid droplet heterogeneity in differentiating adipocytes Open

Mario Majchrzak, Ozren Stojanović, Dalila Ajjaji, Kalthoum Ben M’Barek, Mohyeddine Omrane , et al. · 2023

Summary The storage of fat within lipid droplets (LDs) of adipocytes is critical for whole-body health. Acute fatty acid (FA) uptake by differentiating adipocytes leads to the formation of at least two LD-classes marked by distinct perilip…

A role for endoplasmic reticulum dynamics in the cellular distribution of microtubules Open

Maria S. Tikhomirova, Avihay Kadosh, Aksel J. Saukko‐Paavola, Tom Shemesh, Robin W. Klemm · 2022

Significance The endoplasmic reticulum (ER) and the microtubule (MT) cytoskeleton form a coextensive, dynamic system that pervades eukaryotic cells. The shape of the ER is generated by a set of evolutionarily conserved membrane proteins th…

Data for: A role for endoplasmic reticulum dynamics in the cellular distribution of microtubules Open

Maria S. Tikhomirova, Avihay Kadosh, Aksel J. Saukko‐Paavola, Tom Shemesh, Robin W. Klemm · 2022

This dataset has been furnished in support of the article "A role for endoplasmic reticulum dynamics in the cellular distribution of microtubules" (PNAS, 2022).\n\n\n \n\n\nRaw image data for analysis of junction d…

Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor initiating cells Open

Mara Artibani, Kenta Masuda, Zhiyuan Hu, Pascal C. Rauher, Garry Mallett , et al. · 2021

Similar to tumor-initiating cells (TICs), minimal residual disease (MRD) is capable of reinitiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained …

Lipid molecular timeline profiling reveals diurnal crosstalk between the liver and circulation Open

Richard R. Sprenger, Martin Hermansson, Ditte Neess, Lena Sokol Becciolini, Signe Bek Sørensen , et al. · 2021

Diurnal regulation of whole-body lipid metabolism plays a vital role in metabolic health. Although changes in lipid levels across the diurnal cycle have been investigated, the system-wide molecular responses to both short-acting fasting-fe…

Getting in Touch Is an Important Step: Control of Metabolism at Organelle Contact Sites Open

Robin W. Klemm · 2021

Metabolic pathways are often spread over several organelles and need to be functionally integrated by controlled organelle communication. Physical organelle contact-sites have emerged as critical hubs in the regulation of cellular metaboli…

Essential role of non-vesicular lipid transport in microtubule-controlled cell polarisation Open

M. Hersberger-Trost, D. Dreher, Stephen M. Huisman, Adam Rafal Kijowski, Michèle Gemünden , et al. · 2020

Cell polarisation is a fundamental biological process. Fission yeast is a key model system to study the molecular basis of microtubule-controlled cell polarisation. In this process, cells define prospective growth sites by generating disti…

Principles of organelle spatial organization and interactions Open

Robin W. Klemm, Pedro Carvalho · 2020

MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes Open

Christophe Alexis Cédric Freyre, Pascal C. Rauher, Christer S. Ejsing, Robin W. Klemm · 2019

Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish Open

Gianluca D‘Agati, Elena M. Cabello, Karl Frontzek, Elisabeth J. Rushing, Robin W. Klemm , et al. · 2019

The aberrant activation of developmental processes triggers diverse cancer types. Chordoma is a rare, aggressive tumor arising from transformed notochord remnants. Several potentially oncogenic factors have been found to be deregulated in …

Active Receptor Tyrosine Kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish Open

Gianluca D‘Agati, Elena M. Cabello, Karl Frontzek, Elisabeth J. Rushing, Robin W. Klemm , et al. · 2018

The aberrant activation of developmental processes triggers diverse cancer types. Chordoma is a rare, aggressive tumor arising from transformed notochord remnants. Several potentially oncogenic factors, including several receptor tyrosine …

ER remodeling by the large GTPase atlastin promotes vacuolar growth of <i>Legionella pneumophila</i> Open

Bernhard Steiner, A. Leoni Swart, Amanda Welin, Stephen M. Weber, Nicolas Personnic , et al. · 2017

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