Robyn Lucas
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View article: Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and <i><scp>HLA</scp>‐<scp>DRB1</scp>*1501</i> Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset
Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and <i><span>HLA</span>‐<span>DRB1</span>*1501</i> Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset Open
Objectives Multiple sclerosis (MS) onset risk factors include Epstein–Barr virus (EBV) indices (including host response), lower serum 25‐vitamin D (25(OH)D) levels, low sun exposure, and HLA‐DRB1*1501 . The underlying molecular mechanisms …
View article: Diet-dependent acid-base load is not associated with rate of relapse, annualised disability change, FLAIR, and black hole lesion volume on MRI in a prospective cohort study of those with multiple sclerosis
Diet-dependent acid-base load is not associated with rate of relapse, annualised disability change, FLAIR, and black hole lesion volume on MRI in a prospective cohort study of those with multiple sclerosis Open
Our findings indicate that a higher diet-dependent acid-base load is not associated with a worsening in MS progression and measured inflammatory activity measures.
View article: Association Between Sun Exposure and Risk of Relapse in Pediatric-Onset Multiple Sclerosis
Association Between Sun Exposure and Risk of Relapse in Pediatric-Onset Multiple Sclerosis Open
In this large cohort study of children with MS, greater early childhood and prenatal sun exposure time was associated with lower risk of relapse. Further investigation of sun exposure at other periods is needed to better characterize its i…
View article: Acceptability and Feasibility of the English Version of Elevida, a Self-Guided Online Fatigue Intervention for People With Multiple Sclerosis
Acceptability and Feasibility of the English Version of Elevida, a Self-Guided Online Fatigue Intervention for People With Multiple Sclerosis Open
BACKGROUND: Fatigue is common in multiple sclerosis (MS); it significantly impairs quality of life, and treatment options are limited. A randomized controlled trial of Elevida, a self-guided, online German fatigue intervention, showed sign…
View article: Long-term disability trajectories in multiple sclerosis: a group-based trajectory analysis of the AusLong cohort
Long-term disability trajectories in multiple sclerosis: a group-based trajectory analysis of the AusLong cohort Open
Background Previous natural history studies highlighted a consistent heterogeneity of disability trajectories among individuals with primary or secondary progressive multiple sclerosis (MS). However, evidence on disability progression in r…
View article: Continuing benefits of the Montreal Protocol and protection of the stratospheric ozone layer for human health and the environment
Continuing benefits of the Montreal Protocol and protection of the stratospheric ozone layer for human health and the environment Open
The protection of Earth’s stratospheric ozone (O 3 ) is an ongoing process under the auspices of the universally ratified Montreal Protocol and its Amendments and adjustments. A critical part of this process is the assessment of the enviro…
View article: Environmental plastics in the context of UV radiation, climate change, and the Montreal Protocol
Environmental plastics in the context of UV radiation, climate change, and the Montreal Protocol Open
There are close links between solar UV radiation, climate change, and plastic pollution. UV-driven weathering is a key process leading to the degradation of plastics in the environment but also the formation of potentially harmful plastic …
View article: Plastics in the environment in the context of UV radiation, climate change and the Montreal Protocol: UNEP Environmental Effects Assessment Panel, Update 2023
Plastics in the environment in the context of UV radiation, climate change and the Montreal Protocol: UNEP Environmental Effects Assessment Panel, Update 2023 Open
View article: The immune cell transcriptome is modulated by vitamin D3 supplementation in people with a first demyelinating event participating in a randomized placebo-controlled trial
The immune cell transcriptome is modulated by vitamin D3 supplementation in people with a first demyelinating event participating in a randomized placebo-controlled trial Open
Vitamin D deficiency is a risk factor for developing multiple sclerosis. The PrevANZ trial was conducted to determine if vitamin D3 supplementation can prevent recurrent disease activity in people with a first demyelinating even…
View article: Relative risks of childhood developmental vulnerabilities in three Australian communities with exposure to per- and polyfluoroalkyl substances: data linkage study
Relative risks of childhood developmental vulnerabilities in three Australian communities with exposure to per- and polyfluoroalkyl substances: data linkage study Open
BackgroundAqueous film forming foams (AFFF) containing per- and polyfluoroalkyl substances (PFAS) caused local environmental contamination in three Australian residential areas: Katherine in the Northern Territory (NT), Oakey in Queensland…
View article: Balancing the risks and benefits of sun exposure: A revised position statement for Australian adults
Balancing the risks and benefits of sun exposure: A revised position statement for Australian adults Open
Mass communication campaigns should retain the focus on skin cancer prevention. The new position statement will support the delivery of personalised advice.
View article: Vitamin D did not reduce multiple sclerosis disease activity after a clinically isolated syndrome
Vitamin D did not reduce multiple sclerosis disease activity after a clinically isolated syndrome Open
Low serum levels of 25-hydroxyvitamin D [25(OH)D] and low sunlight exposure are known risk factors for the development of multiple sclerosis. Add-on vitamin D supplementation trials in established multiple sclerosis have been inconclusive.…
View article: Relative Risks of Adverse Perinatal Outcomes in Three Australian Communities Exposed to Per- and Polyfluoroalkyl Substances: Data Linkage Study
Relative Risks of Adverse Perinatal Outcomes in Three Australian Communities Exposed to Per- and Polyfluoroalkyl Substances: Data Linkage Study Open
Introduction: Firefighting foams containing per- and polyfluoroalkyl substances (PFAS) have caused environmental contamination in several Australian residential areas, including Katherine in the Northern Territory (NT), Oakey in Queensland…
View article: Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies
Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies Open
View article: Risk of a first clinical diagnosis of central nervous system demyelination in relation to human herpesviruses in the context of <scp>Epstein–Barr</scp> virus
Risk of a first clinical diagnosis of central nervous system demyelination in relation to human herpesviruses in the context of <span>Epstein–Barr</span> virus Open
Background and purpose Epstein–Barr virus (EBV) is implicated in multiple sclerosis (MS) risk; evidence for other herpesviruses is inconsistent. Here, we test blood markers of infection with human herpesvirus 6 (HHV‐6), varicella zoster vi…
View article: A pro-inflammatory diet in people with multiple sclerosis is associated with an increased rate of relapse and increased FLAIR lesion volume on MRI in early multiple sclerosis: A prospective cohort study
A pro-inflammatory diet in people with multiple sclerosis is associated with an increased rate of relapse and increased FLAIR lesion volume on MRI in early multiple sclerosis: A prospective cohort study Open
Background: A pro-inflammatory diet has been posited to induce chronic inflammation within the central nervous system (CNS), and multiple sclerosis (MS) is an inflammatory disease of the CNS. Objective: We examined whether Dietary Inflamma…
View article: Linkages between COVID-19, solar UV radiation, and the Montreal Protocol
Linkages between COVID-19, solar UV radiation, and the Montreal Protocol Open
View article: Liver and cardiometabolic markers and conditions in a cross-sectional study of three Australian communities living with environmental per- and polyfluoroalkyl substances contamination
Liver and cardiometabolic markers and conditions in a cross-sectional study of three Australian communities living with environmental per- and polyfluoroalkyl substances contamination Open
View article: The effects of exposure to solar radiation on human health
The effects of exposure to solar radiation on human health Open
View article: Vitamin D and Sun Exposure: A Community Survey in Australia
Vitamin D and Sun Exposure: A Community Survey in Australia Open
Sun exposure carries both harms and benefits. Exposing the skin to the sun is the main modifiable cause of skin cancers, which exert a considerable health and economic burden in Australia. The most well-established benefit of exposure to u…
View article: Higher consumption of ultra-processed foods and increased likelihood of central nervous system demyelination in a case-control study of Australian adults
Higher consumption of ultra-processed foods and increased likelihood of central nervous system demyelination in a case-control study of Australian adults Open
View article: Relative rates of cancers and deaths in Australian communities with PFAS environmental contamination associated with firefighting foams: A cohort study using linked data
Relative rates of cancers and deaths in Australian communities with PFAS environmental contamination associated with firefighting foams: A cohort study using linked data Open
There was limited evidence to support an association between living in a PFAS exposure area and risks of cancers or cause-specific deaths.
View article: Cardiometabolic, kidney, and thyroid markers and conditions in three Australian communities living with environmental per- and polyfluoroalkyl substances contamination
Cardiometabolic, kidney, and thyroid markers and conditions in three Australian communities living with environmental per- and polyfluoroalkyl substances contamination Open
BACKGROUND AND AIM: Per- and polyfluoroalkyl substances (PFAS) have been associated with altered kidney, thyroid, and cardiometabolic function markers, particularly elevated total cholesterol, but the evidence for specific health condition…
View article: Exposure to PFAS in Australian communities impacted by environmental contamination; the PFAS Health Study, 2016-2020
Exposure to PFAS in Australian communities impacted by environmental contamination; the PFAS Health Study, 2016-2020 Open
Background Communities impacted by environmental contamination may have higher exposure to per- and polyfluoroalkyl substances (PFAS), which has the potential for both immediate and latent impacts on human health. We investigated PFAS expo…
View article: 2326 Differential methylation mediates significant proportions of environmental and lifestyle factors’ associations with MS risk: results from the Ausimmune case-control study
2326 Differential methylation mediates significant proportions of environmental and lifestyle factors’ associations with MS risk: results from the Ausimmune case-control study Open
Background The mechanisms by which modifiable environmental and lifestyle factors, including Epstein-Barr virus (EBV) exposure, sun exposure/vitamin D, and smoking exert their effects on multiple sclerosis (MS) risk are unclear. Here, we e…
View article: Predictors of progression from a first demyelinating event to clinically definite multiple sclerosis
Predictors of progression from a first demyelinating event to clinically definite multiple sclerosis Open
Understanding the predictors of progression from a first to a second demyelinating event (and formerly, a diagnosis of clinically definite multiple sclerosis) is important clinically. Previous studies have focused on predictors within a si…
View article: Tobacco Control Continues to Work as Smoking Prevalence Declines: Combating Manufactured Uncertainty: Author Response
Tobacco Control Continues to Work as Smoking Prevalence Declines: Combating Manufactured Uncertainty: Author Response Open
View article: Long-term trajectories of employment status, workhours and disability support pension status, after a first episode of CNS demyelination
Long-term trajectories of employment status, workhours and disability support pension status, after a first episode of CNS demyelination Open
Background: People with multiple sclerosis face significant employment-related challenges, with little known of the drivers of these outcomes. Objective: We examined prospective trajectories of employment-related outcomes up to 11 years fo…
View article: Total Dairy Consumption Is Not Associated With Likelihood of a First Clinical Diagnosis of Central Nervous System Demyelination
Total Dairy Consumption Is Not Associated With Likelihood of a First Clinical Diagnosis of Central Nervous System Demyelination Open
Background The evidence associating consumption of dairy products and risk of MS is contradictory and inconclusive. Objective To test associations between dairy consumption and the likelihood of a first clinical diagnosis of central nervou…
View article: Vitamin D composition of Australian game products
Vitamin D composition of Australian game products Open