Robyn S. Klein
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View article: Editorial: Viral impact on CNS: mechanisms of immune dysfunction and cognitive decline
Editorial: Viral impact on CNS: mechanisms of immune dysfunction and cognitive decline Open
View article: Systems neuroimmunology: current bottlenecks, research priorities and future directions
Systems neuroimmunology: current bottlenecks, research priorities and future directions Open
View article: CSF proteomics related to the neurovascular unit are associated with white matter hyperintensity volumes and cerebral microhemorrhages in autosomal dominant Alzheimer disease
CSF proteomics related to the neurovascular unit are associated with white matter hyperintensity volumes and cerebral microhemorrhages in autosomal dominant Alzheimer disease Open
Background Autosomal dominant Alzheimer disease (ADAD) is characterized by genetic mutations affecting the beta‐amyloid (Aß) pathway. However, vascular and immune factors play important roles which are not completely understood. Understand…
View article: CSF proteomics related to the neurovascular unit are associated with white matter hyperintensity volumes and cerebral microhemorrhages in autosomal dominant Alzheimer disease
CSF proteomics related to the neurovascular unit are associated with white matter hyperintensity volumes and cerebral microhemorrhages in autosomal dominant Alzheimer disease Open
Background Autosomal dominant Alzheimer disease (ADAD) is characterized by genetic mutations affecting the beta‐amyloid (Aβ) pathway. However, vascular and immune factors play important roles which are not completely understood. Understand…
View article: Zika virus encephalitis causes transient reduction of functional cortical connectivity
Zika virus encephalitis causes transient reduction of functional cortical connectivity Open
These findings suggest that a robust inflammatory response may contribute to the health of functional brain networks after recovery from infection.
View article: CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment
CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment Open
SARS-CoV-2 infection induces the generation of virus-specific CD4 + and CD8 + effector and memory T cells. However, the contribution of T cells in controlling SARS-CoV-2 during infection is not well understood. Following infection of C57BL…
View article: West Nile Virus-Induced Expression of Senescent Gene Lgals3bp Regulates Microglial Phenotype within Cerebral Cortex
West Nile Virus-Induced Expression of Senescent Gene Lgals3bp Regulates Microglial Phenotype within Cerebral Cortex Open
Microglia, the resident macrophages of the central nervous system, exhibit altered gene expression in response to various neurological conditions. This study investigates the relationship between West Nile Virus infection and microglial se…
View article: West Nile Virus-Induced Expression of Senescent Gene Lgals3bp Regulates Microglial Phenotype within Cerebral Cortex
West Nile Virus-Induced Expression of Senescent Gene Lgals3bp Regulates Microglial Phenotype within Cerebral Cortex Open
Microglia, the resident macrophages of the central nervous system, exhibit altered gene expression in response to various neurological conditions. This study investigates the relationship between West Nile Virus infection, and microglial s…
View article: Editorial Board
Editorial Board Open
View article: Multimodal neuro-nanotechnology: Challenging the existing paradigm in glioblastoma therapy
Multimodal neuro-nanotechnology: Challenging the existing paradigm in glioblastoma therapy Open
Integrating multimodal neuro- and nanotechnology-enabled precision immunotherapies with extant systemic immunotherapies may finally provide a significant breakthrough for combatting glioblastoma (GBM). The potency of this approach lies in …
View article: Editorial Board
Editorial Board Open
View article: CD4+ and CD8+ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment
CD4+ and CD8+ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment Open
SARS-CoV-2 is the causative agent of COVID-19 and continues to pose a significant public health threat throughout the world. Following SARS-CoV-2 infection, virus-specific CD4+ and CD8+ T cells are rapidly generated to form effector and me…
View article: Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons
Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons Open
View article: Editorial Board
Editorial Board Open
View article: Editorial Board
Editorial Board Open
View article: Vaccination prevents IL-1β-mediated cognitive deficits after COVID-19
Vaccination prevents IL-1β-mediated cognitive deficits after COVID-19 Open
Up to 25% of SARS-CoV-2 patients exhibit post-acute cognitive sequelae. Although millions of cases of COVID-19-mediated memory dysfunction are accumulating worldwide, the underlying mechanisms and how vaccination lowers risk are unknown. I…
View article: Editorial Board
Editorial Board Open
View article: Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice
Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice Open
View article: Myeloid cell activation during Zika virus encephalitis predicts recovery of functional cortical connectivity
Myeloid cell activation during Zika virus encephalitis predicts recovery of functional cortical connectivity Open
Neurologic complications of Zika virus (ZIKV) infection across the lifespan have been described during outbreaks in Southeast Asia, South America, and Central America since 2016. In the adult CNS ZIKV tropism for neurons is tightly linked …
View article: Characterization of a S1PR2 specific 11C-labeled radiotracer in streptozotocin-induced diabetic murine model
Characterization of a S1PR2 specific 11C-labeled radiotracer in streptozotocin-induced diabetic murine model Open
View article: Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons
Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons Open
Venezuelan Equine Encephalitis virus ( VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that originate in the nasal cavity after intranasal exposure. While it is known that VEEV has evolved several me…
View article: Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria
Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria Open
Histidine-rich protein II (HRPII) is secreted by Plasmodium falciparum during the blood stage of malaria infection. High plasma levels of HRPII are associated with cerebral malaria, a severe and highly fatal complication of malaria. HRPII …
View article: Microglia at the scene of the crime: what their transcriptomics reveal about brain health
Microglia at the scene of the crime: what their transcriptomics reveal about brain health Open
Purpose of review Microglia, which arise from primitive myeloid precursors that enter the central nervous system (CNS) during early development, are the first responders to any perturbance of homeostasis. Although their activation has beco…
View article: Meningeal MAIT cells maintain meningeal and brain function
Meningeal MAIT cells maintain meningeal and brain function Open
View article: The multitaskers of the brain: Glial responses to viral infections and associated post‐infectious neurologic sequelae
The multitaskers of the brain: Glial responses to viral infections and associated post‐infectious neurologic sequelae Open
Many viral infections cause acute and chronic neurologic diseases which can lead to degeneration of cortical functions. While neurotropic viruses that gain access to the central nervous system (CNS) may induce brain injury directly via inf…
View article: Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination
Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination Open
View article: Neuroinflammation and COVID-19
Neuroinflammation and COVID-19 Open
Coronavirus disease 2019 (COVID-19) has caused a historic pandemic of respiratory disease. COVID-19 also causes acute and post-acute neurological symptoms, which range from mild, such as headaches, to severe, including hemorrhages. Current…
View article: Infection and inflammation: New perspectives on Alzheimer's disease
Infection and inflammation: New perspectives on Alzheimer's disease Open
View article: Targeting IFN-λ Signaling Promotes Recovery from Central Nervous System Autoimmunity
Targeting IFN-λ Signaling Promotes Recovery from Central Nervous System Autoimmunity Open
Type III IFNs (IFNLs) are newly discovered cytokines, acting at epithelial and other barriers, that exert immunomodulatory functions in addition to their primary roles in antiviral defense. In this study, we define a role for IFNLs in main…
View article: Synthesis and evaluation of highly selective quinazoline-2,4-dione ligands for sphingosine-1-phosphate receptor 2
Synthesis and evaluation of highly selective quinazoline-2,4-dione ligands for sphingosine-1-phosphate receptor 2 Open
New quinazoline-2,4-dione analogues were developed as sphingosine 1-phosphate receptor 2 ligands. [ 11 C]2i has great potential to serve as a positron emission tomography probe in peripheral tissue diseases.