Rocío T. Martínez-Nuñez
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View article: Glycan recognition by collectin-11 drives SARS-CoV-2 infectivity and membrane injury of respiratory epithelial cells
Glycan recognition by collectin-11 drives SARS-CoV-2 infectivity and membrane injury of respiratory epithelial cells Open
SARS-CoV-2 respiratory-tract infection affects both vaccinated and unvaccinated persons suggesting factors besides adaptive immunity are operative. We investigated the role of collectin-11 (CL-11), an epithelial-secreted carbohydrate-bindi…
View article: Ex vivo expanded human regulatory T cells promote cholesterol efflux and PON1 expression in oxLDL-exposed macrophages via gap junction-mediated cAMP transfer
Ex vivo expanded human regulatory T cells promote cholesterol efflux and PON1 expression in oxLDL-exposed macrophages via gap junction-mediated cAMP transfer Open
Lipid-driven inflammation contributes to the development of atherosclerosis, and regulatory T cells (Tregs) have been proposed to influence macrophage responses to lipid stress. While adoptive Treg transfer has been shown to be safe in cli…
View article: The RNA binding protein Insulin Growth factor 2 binding Protein 3 (IGF2BP3) modulates IL-13/IL-4 signalling in human bronchial epithelial cells and is dysregulated in type 2 disease
The RNA binding protein Insulin Growth factor 2 binding Protein 3 (IGF2BP3) modulates IL-13/IL-4 signalling in human bronchial epithelial cells and is dysregulated in type 2 disease Open
Type 2 immune responses are mainly driven by interleukins (IL)-4 and -13. Typically directed against extracellular pathogens, type 2 immunity is dysregulated in allergic diseases. IL-4 and IL-13 signal via type I and II receptors; while IL…
View article: Influence of <i>Spinacia oleracea</i> leaf extract concentration on silver nanoparticle formation and evaluation of antimicrobial properties
Influence of <i>Spinacia oleracea</i> leaf extract concentration on silver nanoparticle formation and evaluation of antimicrobial properties Open
Silver nanoparticle size reduced with increaing S. oleracea /concentration. S. oleracea concentration influenced antimicrobial activity. Plant extract concentration impacts silver nanoparticle synthesis, size and resultant antimicrobial ac…
View article: Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplay
Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplay Open
Nucleotide sequences along a gene provide instructions to transcriptional and cotranscriptional machinery allowing genome expansion into the transcriptome. Nucleotide sequence can often be shared between two genes and in some occurrences, …
View article: Coordinated nasal mucosa-mediated immunity accelerates recovery from COVID-19
Coordinated nasal mucosa-mediated immunity accelerates recovery from COVID-19 Open
Introduction Understanding the interplay of immune mediators in relation to clinical outcomes during acute infection has the potential to highlight immune networks critical to symptom recovery. The objective of the present study was to elu…
View article: Atheroprotective Human Regulatory T Cells Enhance Cholesterol Efflux by Regulating ABCA1 and PON1 Expression in Macrophages
Atheroprotective Human Regulatory T Cells Enhance Cholesterol Efflux by Regulating ABCA1 and PON1 Expression in Macrophages Open
View article: KCL TEST: an open-source inspired asymptomatic SARS-CoV-2 surveillance programme in an academic institution
KCL TEST: an open-source inspired asymptomatic SARS-CoV-2 surveillance programme in an academic institution Open
Rapid and accessible testing was paramount in the management of the COVID-19 pandemic. Our university established KCL TEST: a SARS-CoV-2 asymptomatic testing programme that enabled sensitive and accessible PCR testing of SARS-CoV-2 RNA in …
View article: Ceg1 depletion reveals mechanisms governing degradation of non-capped RNAs in Saccharomyces cerevisiae
Ceg1 depletion reveals mechanisms governing degradation of non-capped RNAs in Saccharomyces cerevisiae Open
View article: The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma
The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma Open
Introduction: Asthma is the most common chronic inflammatory disease of the airways. The airway epithelium is a key driver of the disease, and numerous studies have established genome-wide differences in mRNA expression between health and …
View article: KCL TEST: an open-source inspired asymptomatic SARS-CoV-2 surveillance programme in an academic institution
KCL TEST: an open-source inspired asymptomatic SARS-CoV-2 surveillance programme in an academic institution Open
Testing was paramount in the management of the COVID-19 pandemic. Our university established KCL TEST: a SARS-CoV-2 asymptomatic testing programme that enabled sensitive and accessible PCR testing of SARS-CoV-2 RNA in saliva. We performed …
View article: The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma
The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma Open
Asthma is the most common chronic inflammatory disease of the airways. The airway epithelium is a key driver of the disease, and numerous studies have established genome-wide differences in mRNA expression between health and asthma. Howeve…
View article: Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplay
Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplay Open
Nucleotide sequences along a gene provide instructions to transcriptional and co-transcriptional machinery allowing genome expansion into the transcriptome. Interestingly, nucleotide sequence can often be shared between two genes and in so…
View article: Asthma innovations from the first International Collaborative Asthma Network forum
Asthma innovations from the first International Collaborative Asthma Network forum Open
Background Many patients have uncontrolled asthma despite available treatments. Most of the new asthma therapies have focused on type 2 (T2) inflammation, leaving an unmet need for innovative research into mechanisms of asthma beyond T2 an…
View article: Coordinated nasal mucosa-mediated immunity accelerates recovery from COVID-19
Coordinated nasal mucosa-mediated immunity accelerates recovery from COVID-19 Open
Viral infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induce a dynamic immune environment. Using nasal mucosal samples in 139 participants from the STOIC study (community-based randomised clinical trial for th…
View article: The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids
The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids Open
Glucocorticoids (GCs) are one of the most used anti-inflammatory drugs worldwide. Despite their widespread use, our understanding of their post-transcriptional effects remains poorly understood. The tristetraprolin (TTP) RNA binding protei…
View article: Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2
Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2 Open
The COVID-19 pandemic has accelerated the need to identify new antiviral therapeutics at pace, including through drug repurposing. We employed a Quadratic Unbounded Binary Optimization (QUBO) model, to search for compounds similar to Remde…
View article: Homebrew: Protocol for glassmilk-based nucleic-acid extraction for SARS-CoV-2 diagnostics
Homebrew: Protocol for glassmilk-based nucleic-acid extraction for SARS-CoV-2 diagnostics Open
View article: Homebrew: An economical and sensitive glassmilk-based nucleic-acid extraction method for SARS-CoV-2 diagnostics
Homebrew: An economical and sensitive glassmilk-based nucleic-acid extraction method for SARS-CoV-2 diagnostics Open
Management of COVID-19 and other epidemics requires large-scale diagnostic testing. The gold standard for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains reverse transcription quantitative PCR (qRT-PCR) analy…
View article: Tackling the global impact of substandard and falsified and unregistered/unlicensed anti-tuberculosis medicines
Tackling the global impact of substandard and falsified and unregistered/unlicensed anti-tuberculosis medicines Open
Substandard and falsified (SF) medicines are a global health challenge with the World Health Organization (WHO) estimating that 1 in 10 of medicines in low- and middle-income countries (LMICs) are SF. Antimicrobials (i.e. antimalarials, an…
View article: miR-155-overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T-cell activation
miR-155-overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T-cell activation Open
MicroRNAs (miRs) are known to regulate pro-inflammatory effector functions of myeloid cells, and miR dysregulation is implicated in rheumatoid arthritis (RA), a condition characterized by inflammation and destruction of the joints. We show…
View article: Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation
Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation Open
There is a worldwide need for reagents to perform SARS-CoV-2 detection. Some laboratories have implemented kit-free protocols, but many others do not have the capacity to develop these and/or perform manual processing. We provide multiple …
View article: Drug repurposing based on a Quantum-Inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2 including vitamin B12
Drug repurposing based on a Quantum-Inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2 including vitamin B12 Open
The COVID-19 pandemic has accelerated the need to identify new therapeutics at pace, including through drug repurposing. We employed a Quadratic Unbounded Binary Optimization (QUBO) model, to search for compounds similar to Remdesivir (RDV…
View article: Cellular and molecular mechanisms of IMMunE dysfunction and Recovery from SEpsis-related critical illness in adults: An observational cohort study (IMMERSE) protocol paper
Cellular and molecular mechanisms of IMMunE dysfunction and Recovery from SEpsis-related critical illness in adults: An observational cohort study (IMMERSE) protocol paper Open
Sepsis is a common illness. Immune responses are considered major drivers of sepsis illness and outcomes. However, there are no proven immunomodulator therapies in sepsis. We hypothesised that in-depth characterisation of sepsis-specific i…
View article: Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans
Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans Open
View article: Translational Research in the Time of COVID-19—Dissolving Boundaries
Translational Research in the Time of COVID-19—Dissolving Boundaries Open
Scientific research gathers data and evidence to test hypotheses within a solid almost philosophical framework that has evolved over hundreds of years [1].About 30 years ago, the concept of translational research emerged across life scienc…
View article: The COVID-19 Early Detection in Doctors and Healthcare Workers (CEDiD) Study: study protocol for a prospective observational trial
The COVID-19 Early Detection in Doctors and Healthcare Workers (CEDiD) Study: study protocol for a prospective observational trial Open
Background The global COVID-19 pandemic has caused worldwide disruption with its exponential spread mandating national and international lockdown measures. Hospital-associated transmission has been identified as a major factor in the perpe…
View article: Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection
Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection Open
Antibody (Ab) responses to SARS-CoV-2 can be detected in most infected individuals 10-15 days following the onset of COVID-19 symptoms. However, due to the recent emergence of this virus in the human population it is not yet known how long…
View article: Alzheimer’s disease-related dysregulation of mRNA translation causes key pathological features with ageing
Alzheimer’s disease-related dysregulation of mRNA translation causes key pathological features with ageing Open
View article: Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation
Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation Open
There is a worldwide need for reagents to perform SARS-CoV-2 detection. Some laboratories have implemented kit-free protocols, but many others do not have the capacity to develop these and/or perform manual processing. We provide multiple …