Rod T. Mitchell
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View article: Paternal over- and under-nutrition program fetal and placental development in a sex-specific manner in mice
Paternal over- and under-nutrition program fetal and placental development in a sex-specific manner in mice Open
The association between sub-optimal paternal diet and offspring well-being is becoming established. However, the underlying mechanisms are yet to be fully defined. The aim of this study was to establish the impact of over- and under-nutrit…
View article: Development and evaluation of the first fertility preservation patient decision aid to support boys and young men with cancer: The Cancer, Fertility and Me for Boys and Young Men research protocol.
Development and evaluation of the first fertility preservation patient decision aid to support boys and young men with cancer: The Cancer, Fertility and Me for Boys and Young Men research protocol. Open
Introduction Many cancer treatments can result in reduced fertility, impacting survivors’ opportunities for biological parenthood. Fertility preservation (FP) methods for boys and young men, such as cryopreservation of testicular tissue or…
View article: Is the time right for transplanting immature testicular tissue or cells to restore male fertility? Expert perspectives on clinical implementation of autotransplantation of cryopreserved testicular tissue or cells for fertility restoration
Is the time right for transplanting immature testicular tissue or cells to restore male fertility? Expert perspectives on clinical implementation of autotransplantation of cryopreserved testicular tissue or cells for fertility restoration Open
View article: ESHRE good practice recommendations on fertility preservation involving testicular tissue cryopreservation in children receiving gonadotoxic therapies
ESHRE good practice recommendations on fertility preservation involving testicular tissue cryopreservation in children receiving gonadotoxic therapies Open
STUDY QUESTION How should fertility preservation in child and adolescent males receiving gonadotoxic therapies be managed? SUMMARY ANSWER There were 44 recommendations formulated to provide guidance on all aspects of fertility preservation…
View article: O-106 Good practice recommendations on fertility preservation in child and adolescent males receiving gonadotoxic therapies
O-106 Good practice recommendations on fertility preservation in child and adolescent males receiving gonadotoxic therapies Open
Study question How should fertility preservation in child and adolescent males receiving gonadotoxic therapies be managed? Summary answer Forty-two recommendations were formulated to provide guidance on all aspects of fertility preservatio…
View article: A core outcome set for future male infertility research: development of an international consensus
A core outcome set for future male infertility research: development of an international consensus Open
STUDY QUESTION Can a core outcome set be developed through a global consensus to standardize outcome selection, collection, comparison, and reporting in future male infertility trials? SUMMARY ANSWER A minimum dataset, known as a ‘core out…
View article: Germ cell quantification in human fetal and prepubertal testis tissues: a comparison of current methodologies
Germ cell quantification in human fetal and prepubertal testis tissues: a comparison of current methodologies Open
Methods to quantify germ cell number in human immature testicular tissues are essential to evaluate the impact of chemotherapy exposures and to optimise cryopreservation protocols used in fertility preservation for prepubertal boys. Establ…
View article: Spatially resolved micromechanical characterisation of human testis tissue reveals distinct signatures across developing, adult and pathological tissue states
Spatially resolved micromechanical characterisation of human testis tissue reveals distinct signatures across developing, adult and pathological tissue states Open
View article: The impact of <i>in utero</i> exposure to cancer treatments on foetal reproductive development and future fertility: a systematic review
The impact of <i>in utero</i> exposure to cancer treatments on foetal reproductive development and future fertility: a systematic review Open
STUDY QUESTION Does cancer treatment during pregnancy affect gonadal development in the exposed foetus? SUMMARY ANSWER Our systematic review revealed that exposure in utero to many cancer therapies does negatively impact gonadal developmen…
View article: Impacts of cancer therapy on male fertility: Past and present
Impacts of cancer therapy on male fertility: Past and present Open
Over the past two decades, advances in cancer therapy have significantly improved survival rates, particularly in childhood cancers. Still, many treatments pose a substantial risk for diminishing future fertility potential due to the gonad…
View article: Sexual health and fertility in <scp>Duchenne</scp> muscular dystrophy—An exploratory study
Sexual health and fertility in <span>Duchenne</span> muscular dystrophy—An exploratory study Open
Introduction/Aims Recent clinical guidelines recommend that adolescents with Duchenne muscular dystrophy (DMD) who are on daily glucocorticoid treatment should be offered pubertal induction in order to ensure adult levels of sex hormones a…
View article: A 20-year overview of fertility preservation in boys: new insights gained through a comprehensive international survey
A 20-year overview of fertility preservation in boys: new insights gained through a comprehensive international survey Open
STUDY QUESTION Twenty years after the inception of the first fertility preservation programme for pre-pubertal boys, what are the current international practices with regard to cryopreservation of immature testicular tissue? SUMMARY ANSWER…
View article: Prior exposure to alkylating agents negatively impacts testicular organoid formation in cells obtained from childhood cancer patients
Prior exposure to alkylating agents negatively impacts testicular organoid formation in cells obtained from childhood cancer patients Open
STUDY QUESTION Can human pre- and peri-pubertal testicular cells obtained from childhood cancer patients, previously treated with chemotherapy, form testicular organoids (TOs)? SUMMARY ANSWER Organoid formation from testicular tissue colle…
View article: Testicular tissue re-implantation and the ‘hostile testis’
Testicular tissue re-implantation and the ‘hostile testis’ Open
Journal Article Testicular tissue re-implantation and the 'hostile testis' Get access Rod T Mitchell, Rod T Mitchell Centre for Reproductive Health, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UKDepartmen…
View article: Determining the optimal time interval between sample acquisition and cryopreservation when processing immature testicular tissue to preserve fertility
Determining the optimal time interval between sample acquisition and cryopreservation when processing immature testicular tissue to preserve fertility Open
The cryopreservation of immature testicular tissue (ITT) prior to gonadotoxic therapy is crucial for fertility preservation in prepubertal boys with cancer. However, the optimal holding time between tissue collection and cryopreservation h…
View article: Evaluation of Ex Vivo Adrenocorticotropic Hormone Responsiveness of Human Fetal Testis
Evaluation of Ex Vivo Adrenocorticotropic Hormone Responsiveness of Human Fetal Testis Open
Testicular adrenal rest tumors (TARTs), commonly occurring in males with congenital adrenal hyperplasia, may arise from chronic stimulation of adrenocorticotropic hormone (ACTH)–sensitive cells in the testes. It is not yet established whet…
View article: Molecular pathways in placental-fetal development and disruption
Molecular pathways in placental-fetal development and disruption Open
View article: Is ongoing testosterone required after pubertal induction in Duchenne muscular dystrophy?
Is ongoing testosterone required after pubertal induction in Duchenne muscular dystrophy? Open
Glucocorticoids (GCs) reduce inflammation and preserve muscle function in boys with Duchenne muscular dystrophy (DMD) but cause pubertal delay. Pubertal induction with testosterone is recommended but longer-term outcome is unknown. Objecti…
View article: Consistency of findings between experimental and observational analyses of placental mono-n-butyl phthalate (MnBP) and anti-androgenic effects
Consistency of findings between experimental and observational analyses of placental mono-n-butyl phthalate (MnBP) and anti-androgenic effects Open
BACKGROUND AND AIM: Prenatal phthalates, measured in maternal urine, are associated with anti-androgenic effects in the male fetus. Here, phthalates were measured in placental chorion without (CS, chorion smooth) and with villi (CF, chorio…
View article: Dexamethasone affects human fetal adrenal steroidogenesis and subsequent ACTH response in an ex vivo culture model
Dexamethasone affects human fetal adrenal steroidogenesis and subsequent ACTH response in an ex vivo culture model Open
Introduction Administration of dexamethasone (DEX) has been used experimentally to suppress androgenization of external genitalia in 46,XX fetuses with congenital adrenal hyperplasia. Despite this, the prenatal biological mechanism-of-acti…
View article: Going back to the start: do cancer and haematological disorders affect germ cells in prepubertal boys?
Going back to the start: do cancer and haematological disorders affect germ cells in prepubertal boys? Open
Recent evidence shows the need for optimal counselling about the adverse effects of cancer treatments on reproductive tissues and options for preserving fertility in prepubertal paediatric males (Mulder et al., 2021). Some of the current c…
View article: O-114 Fertility preservation in males with hereditary cancer syndromes: balancing the risks and benefits
O-114 Fertility preservation in males with hereditary cancer syndromes: balancing the risks and benefits Open
View article: Human development and reproduction in space—a European perspective
Human development and reproduction in space—a European perspective Open
View article: Granulocyte-colony stimulating factor does not prevent in vitro cisplatin-induced germ cell reduction in immature human and mouse testis
Granulocyte-colony stimulating factor does not prevent in vitro cisplatin-induced germ cell reduction in immature human and mouse testis Open
View article: Impact of taxane-based chemotherapeutics on male reproductive function
Impact of taxane-based chemotherapeutics on male reproductive function Open
Lay summary Men and boys with cancer treated with chemotherapy are known to have reduced fertility following their treatment. This is because some chemotherapy drugs can damage the cells in the testicles that make sperm. This study found t…
View article: Sex steroid priming for growth hormone stimulation testing in children and adolescents with short stature: A systematic review
Sex steroid priming for growth hormone stimulation testing in children and adolescents with short stature: A systematic review Open
Objective Growth hormone stimulation testing (GHST) is used to diagnose growth hormone deficiency (GHD) in children. As sex steroids impact on anterior pituitary function, there is concern around the efficacy of GHST in peripubertal childr…
View article: The impact of vincristine on testicular development and function in childhood cancer
The impact of vincristine on testicular development and function in childhood cancer Open
BACKGROUND Increasing childhood cancer survival rates in recent decades have led to an increased focus on fertility as a long-term complication of cancer treatment. Male childhood cancer survivors often face compromised testicular function…
View article: Expression of Intermediate Filaments in the Developing Testis and Testicular Germ Cell Cancer
Expression of Intermediate Filaments in the Developing Testis and Testicular Germ Cell Cancer Open
Cytokeratin and desmin expression have been associated with Sertoli cell maturity and the development of testicular germ cell cancer (TGCC). Thus, the present study aimed to characterize the expression of these intermediate filaments in no…
View article: Identification of a window of androgen sensitivity for somatic cell function in human fetal testis cultured ex vivo
Identification of a window of androgen sensitivity for somatic cell function in human fetal testis cultured ex vivo Open
View article: Research Note: Comparison of two methods to measure broiler tibia morphology
Research Note: Comparison of two methods to measure broiler tibia morphology Open