Paul J. Clark
YOU?
Author Swipe
View article: Measuring lifetime alcohol exposure: A scoping review and implications for translational research and alcohol‐related harm
Measuring lifetime alcohol exposure: A scoping review and implications for translational research and alcohol‐related harm Open
Background and aims Understanding lifetime alcohol exposure is fundamental to appreciating the risks of alcohol dependence and the multiplicity of alcohol‐related harms, such as cirrhosis. However, most research relies on self‐reported alc…
View article: Cause‐specific mortality among Queensland people with cirrhosis, by cirrhosis aetiology and decompensation status, 2007–22: a retrospective cohort study
Cause‐specific mortality among Queensland people with cirrhosis, by cirrhosis aetiology and decompensation status, 2007–22: a retrospective cohort study Open
Objective To determine the cumulative incidence of overall and cause‐specific mortality among Queensland residents admitted to hospital with cirrhosis during 2007–22, by cirrhosis aetiology. Study design Retrospective cohort study; analysi…
View article: N-acetyl cysteine for the treatment of alcohol use disorder: study protocol for a multi-site, double-blind randomised controlled trial (NAC-AUD study)
N-acetyl cysteine for the treatment of alcohol use disorder: study protocol for a multi-site, double-blind randomised controlled trial (NAC-AUD study) Open
Introduction Current treatments for alcohol use disorders (AUD) have limited efficacy. A previous 28-day pilot trial of N-acetyl cysteine (NAC) vs placebo found NAC to be feasible and safe, with evidence of improvement on some measures of …
View article: Overcoming disparities in hepatocellular carcinoma outcomes in First Nations Australians: a strategic plan for action
Overcoming disparities in hepatocellular carcinoma outcomes in First Nations Australians: a strategic plan for action Open
Every year, about 1800 Australians die of hepatocellular carcinoma (HCC), the most common type of primary liver cancer.1 Aboriginal and Torres Strait Islander peoples of Australia (hereon respectfully referred to as First Nations Australia…
View article: Alcohol does not impact chronic hepatitis <scp>C</scp> treatment outcomes but increases risk for progressive liver disease: <scp>Findings</scp> from a prospective multicentre <scp>Australian</scp> study (<scp>OPERA‐C</scp>)
Alcohol does not impact chronic hepatitis <span>C</span> treatment outcomes but increases risk for progressive liver disease: <span>Findings</span> from a prospective multicentre <span>Australian</span> study (<span>OPERA‐C</span>) Open
Introduction Alcohol use is common in patients with chronic hepatitis C virus (HCV) infection. We examined the impact of alcohol use on direct‐acting antiviral (DAA) therapy outcome and the clinical course of liver disease and 2‐year survi…
View article: Hepatitis C Virus Antiviral Drug Resistance and Salvage Therapy Outcomes Across Australia
Hepatitis C Virus Antiviral Drug Resistance and Salvage Therapy Outcomes Across Australia Open
Background Hepatitis C virus (HCV) infection can now be cured with well-tolerated direct-acting antiviral (DAA) therapy. However, a potential barrier to HCV elimination is the emergence of resistance-associated substitutions (RASs) that re…
View article: Glycogenic hepatopathy associated with hepatic steatosis in type 1 diabetes Short title: GH associated with MAFLD in T1DM
Glycogenic hepatopathy associated with hepatic steatosis in type 1 diabetes Short title: GH associated with MAFLD in T1DM Open
Purpose: Glycogenic hepatopathy is associated with significant psychosocial consequences and health costs. Metabolic Dysfunction-Associated Steatotic Liver Disease and glycogenic hepatopathy are frequently confused as “fatty liver” when se…
View article: Broadening and strengthening the health providers caring for patients with chronic hepatitis C may improve continuity of care
Broadening and strengthening the health providers caring for patients with chronic hepatitis C may improve continuity of care Open
Background Direct‐acting antiviral (DAA) therapies for hepatitis C virus infection (HCV) lead to excellent rates of sustained virological response (SVR). However, loss to follow‐up (LTFU) for SVR testing remains a challenge. We examine fac…
View article: Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and Therapeutics
Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and Therapeutics Open
Non-alcoholic fatty liver disease (NAFLD) describes a steatotic (or fatty) liver occurring as a consequence of a combination of metabolic, environmental, and genetic factors, in the absence of significant alcohol consumption and other live…
View article: Changing Prevalence of Medication Use in People with Cirrhosis: A Retrospective Cohort Study Using Pharmaceutical Benefits Scheme Data
Changing Prevalence of Medication Use in People with Cirrhosis: A Retrospective Cohort Study Using Pharmaceutical Benefits Scheme Data Open
Polypharmacy is common in people with cirrhosis and some medication groups may be overused. Pharmacovigilance is required and future medication safety efforts should target high-risk prescribing practices and promote medication rationalisa…
View article: Monitoring quality of care in hepatocellular carcinoma: A modified Delphi consensus
Monitoring quality of care in hepatocellular carcinoma: A modified Delphi consensus Open
Although there are several established international guidelines on the management of hepatocellular carcinoma (HCC), there is limited information detailing specific indicators of good quality care. The aim of this study was to develop a co…
View article: Australian general practitioners’ perceptions of the barriers and opportunities for community-based care of patients with viral hepatitis: a mixed methods study
Australian general practitioners’ perceptions of the barriers and opportunities for community-based care of patients with viral hepatitis: a mixed methods study Open
Introduction Engagement of general practitioners (GPs) is essential to improving rates of diagnosis and treatment of viral hepatitis, as traditional tertiary hospital-based models of care often face challenges. Aim We investigated Australi…
View article: Hepatitis C treatment outcomes for Australian First Nations Peoples: equivalent SVR rate but higher rates of loss to follow-up
Hepatitis C treatment outcomes for Australian First Nations Peoples: equivalent SVR rate but higher rates of loss to follow-up Open
Background First Nations Peoples of Australia are disproportionally affected by hepatitis C (HCV) infection. Through a prospective study we evaluated the outcome of direct-acting antiviral (DAA) therapy among First Nations Peoples with HCV…
View article: Targeted antiviral treatment of hepatitis B virus in culturally and linguistically diverse populations to achieve elimination targets in Australia
Targeted antiviral treatment of hepatitis B virus in culturally and linguistically diverse populations to achieve elimination targets in Australia Open
The majority of Australia's hepatitis B virus (HBV) burden is borne by culturally and linguistically diverse (CALD) populations, and antiviral treatment is the mainstay of intervention. Using modelling, we estimated the impact of targeted …
View article: Near-Fatal Hepatic Complication After Cardiac Catheter Ablation
Near-Fatal Hepatic Complication After Cardiac Catheter Ablation Open
Radiofrequency cardiac ablation is increasingly performed for the management of dysrhythmias. Bleeding is a well-known complication of this procedure. We present a rare case of a near-fatal iatrogenic hepatic hemorrhage after cardiac cathe…
View article: Disparities in Unmet Needs in Indigenous and Non-Indigenous Australians with Cirrhosis: An Exploratory Study
Disparities in Unmet Needs in Indigenous and Non-Indigenous Australians with Cirrhosis: An Exploratory Study Open
PURPOSE: Understanding and responding to the supportive care needs of people with cirrhosis is essential to quality care. Indigenous Australians, Aboriginal and Torres Strait Islander people, are overrepresented amongst patients with cirrh…
View article: 1203Predictors of treatment and survival in hepatocellular carcinoma patients: A Bayesian parametric survival analysis
1203Predictors of treatment and survival in hepatocellular carcinoma patients: A Bayesian parametric survival analysis Open
Background Culturally and linguistically diverse communities face several challenges to receiving screening and curative treatment of hepatocellular carcinoma (HCC). We reported the predictors of receipt of treatment and survival in a coho…
View article: 1204Modelling impact of targeted hepatitis B treatment for culturally and linguistically diverse populations in Australia
1204Modelling impact of targeted hepatitis B treatment for culturally and linguistically diverse populations in Australia Open
Background Antiviral treatment gap in culturally and linguistically diverse (CALD) populations may be a barrier progress in national elimination. Using modelling, we estimated and predicted the impact of antiviral treatment and migration o…
View article: Protecting persons at-risk of viral hepatitis and alcohol-related liver disease during the pandemic and beyond: mitigating the impact of coronavirus disease 2019 on liver health
Protecting persons at-risk of viral hepatitis and alcohol-related liver disease during the pandemic and beyond: mitigating the impact of coronavirus disease 2019 on liver health Open
Background Treatment seeking for people with alcohol use disorders (AUD), injecting drug use and viral hepatitis is low, and has worsened during the coronavirus disease 2019 (COVID-19) pandemic. Deferring clinical care and increasing drug …
View article: Remoteness of residence predicts tumor stage, receipt of treatment, and mortality in patients with hepatocellular carcinoma
Remoteness of residence predicts tumor stage, receipt of treatment, and mortality in patients with hepatocellular carcinoma Open
Background and Aim Surveillance and early detection and curative treatment of hepatocellular carcinoma (HCC) are the mainstay of improving survival for patients, but there are several barriers to achieving this goal. We reported the impact…
View article: Hepatocellular carcinoma amongst Aboriginal and Torres Strait Islander peoples of Australia
Hepatocellular carcinoma amongst Aboriginal and Torres Strait Islander peoples of Australia Open
Such data provide a call to action to help design and implement health literacy, liver management and HCC surveillance programs for Indigenous people to help close the liver cancer mortality gap.
View article: Fitting health care to people: understanding and adapting to the epidemiology and health literacy of people affected by viral hepatitis from culturally and linguistically diverse migrant backgrounds
Fitting health care to people: understanding and adapting to the epidemiology and health literacy of people affected by viral hepatitis from culturally and linguistically diverse migrant backgrounds Open
Background This study explored the epidemiology and health literacy of people affected by viral hepatitis (VH) from migrant culturally and linguistically diverse (CALD) backgrounds attending a community-based general practitioner and speci…
View article: The Patient’s Perspective in Cirrhosis: Unmet Supportive Care Needs Differ by Disease Severity, Etiology, and Age
The Patient’s Perspective in Cirrhosis: Unmet Supportive Care Needs Differ by Disease Severity, Etiology, and Age Open
Patients with cirrhosis have significant physical, psychological, and practical needs. We documented patients’ perceived need for support with these issues and the differences with increasing liver disease severity, etiology, and age. Usin…