Rodney Ogwang
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View article: Controlled human malaria infection studies: insights into recent advances and key immunological and ethical implementation lessons
Controlled human malaria infection studies: insights into recent advances and key immunological and ethical implementation lessons Open
Controlled human infection studies offer a unique opportunity to study the efficacy of novel interventions, mechanisms of infection and disease, as well as determine correlates of protection that may underpin the development of novel inter…
View article: R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial
R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial Open
Introduction The recently licenced R21/Matrix-M vaccine induces a protective antibody response. In this study, we examined vaccine-induced responses in semi-immune adults in a controlled human malaria infection (CHMI) Phase IIb clinical tr…
View article: Vaccine-induced responses to R21/Matrix-M – an analysis of samples from a phase 1b age de-escalation, dose-escalation trial
Vaccine-induced responses to R21/Matrix-M – an analysis of samples from a phase 1b age de-escalation, dose-escalation trial Open
Introduction The pre-erythrocytic malaria vaccine R21 vaccine adjuvanted with Matrix-M reported good efficacy (75%) in an ongoing phase 3 trial and was recommended World Health Organization for use in children 5–36 months. Vaccine-induced …
View article: The cause of nodding syndrome remains unknown – Authors' reply
The cause of nodding syndrome remains unknown – Authors' reply Open
View article: Breadth of Fc-mediated effector function correlates with clinical immunity following human malaria challenge
Breadth of Fc-mediated effector function correlates with clinical immunity following human malaria challenge Open
Malaria is a life-threatening disease of global health importance, particularly in sub-Saharan Africa. The growth inhibition assay (GIA) is routinely used to evaluate, prioritize, and quantify the efficacy of malaria blood-stage vaccine ca…
View article: Doxycycline for the treatment of nodding syndrome: a randomised, placebo-controlled, phase 2 trial
Doxycycline for the treatment of nodding syndrome: a randomised, placebo-controlled, phase 2 trial Open
View article: Bi-isotype immunoglobulins enhance antibody-mediated neutrophil activity against Plasmodium falciparum parasites
Bi-isotype immunoglobulins enhance antibody-mediated neutrophil activity against Plasmodium falciparum parasites Open
Background Malaria remains a major global health priority, and monoclonal antibodies (mAbs) are emerging as potential new tools to support efforts to control the disease. Recent data suggest that Fc-dependent mechanisms of immunity are imp…
View article: WCN24-2067 REGIONAL DIFFERENCES IN ACUTE KIDNEY INJURY IN UGANDAN CHILDREN HOSPITALIZED FOR HYPOXEMIA
WCN24-2067 REGIONAL DIFFERENCES IN ACUTE KIDNEY INJURY IN UGANDAN CHILDREN HOSPITALIZED FOR HYPOXEMIA Open
Introduction: Acute kidney injury (AKI) is associated with increased mortality in hospitalized patients and incidence is highest in resource limited settings. The objective of this study was to assess sub-National regional differences in t…
View article: WCN24-931 AKI PHENOTYPES IN UGANDAN CHILDREN HOSPITALIZED WITH HYPOXEMIA AND MALARIA
WCN24-931 AKI PHENOTYPES IN UGANDAN CHILDREN HOSPITALIZED WITH HYPOXEMIA AND MALARIA Open
View article: Antibody-Dependent Respiratory Burst against Plasmodium falciparum Merozoites in Individuals Living in an Area with Declining Malaria Transmission
Antibody-Dependent Respiratory Burst against Plasmodium falciparum Merozoites in Individuals Living in an Area with Declining Malaria Transmission Open
Malaria transmission intensity affects the development of naturally acquired immunity to malaria. An absolute correlate measure of protection against malaria is lacking. However, antibody-mediated functions against Plasmodium falciparum co…
View article: Antibody-Dependent Respiratory Burst against <em>Plasmodium falciparum</em> Merozoites in Individuals Living in an Area with Declining Malaria Transmission
Antibody-Dependent Respiratory Burst against <em>Plasmodium falciparum</em> Merozoites in Individuals Living in an Area with Declining Malaria Transmission Open
Malaria transmission intensity affects the development of naturally acquired immunity to malaria. An absolute correlate of protection against malaria is lacking. However, anti-body-mediated functions against P. falciparum correlate with pr…
View article: Doxycycline for the Treatment of Nodding Syndrome: A Phase II, Randomised Placebo-Controlled Trial
Doxycycline for the Treatment of Nodding Syndrome: A Phase II, Randomised Placebo-Controlled Trial Open
View article: Comparison of Structural Changes in Nodding Syndrome and Other Epilepsies Associated With <i>Onchocerca volvulus</i>
Comparison of Structural Changes in Nodding Syndrome and Other Epilepsies Associated With <i>Onchocerca volvulus</i> Open
This is the first study to show that cerebral and cerebellar atrophy correlated with the severity of NS disability, providing an imaging marker for these endemic epileptic disorders that until now have remained poorly characterized. Both N…
View article: Asplenia and spleen hypofunction
Asplenia and spleen hypofunction Open
View article: Neutrophil gelatinase-associated lipocalin is elevated in children with acute kidney injury and sickle cell anemia, and predicts mortality
Neutrophil gelatinase-associated lipocalin is elevated in children with acute kidney injury and sickle cell anemia, and predicts mortality Open
View article: Epstein–Barr virus and malaria upregulate AID and APOBEC3 enzymes, but only AID seems to play a major mutagenic role in Burkitt lymphoma
Epstein–Barr virus and malaria upregulate AID and APOBEC3 enzymes, but only AID seems to play a major mutagenic role in Burkitt lymphoma Open
Endemic Burkitt lymphoma (eBL) is characterized by an oncogenic IGH/c‐MYC translocation and Epstein–Barr virus (EBV) positivity, and is epidemiologically linked to Plasmodium falciparum malaria. Both EBV and malaria are thought to contribu…
View article: Neuroimmunology of Common Parasitic Infections in Africa
Neuroimmunology of Common Parasitic Infections in Africa Open
Parasitic infections of the central nervous system are an important cause of morbidity and mortality in Africa. The neurological, cognitive, and psychiatric sequelae of these infections result from a complex interplay between the parasites…
View article: Epilepsy in Onchocerca volvulus Sero-Positive Patients From Northern Uganda—Clinical, EEG and Brain Imaging Features
Epilepsy in Onchocerca volvulus Sero-Positive Patients From Northern Uganda—Clinical, EEG and Brain Imaging Features Open
Globally, epilepsy is the most common chronic neurological disorder. The incidence in sub-Saharan Africa is 2-3 times higher than that in high income countries. Infection by Onchocerca volvulus may be an underlying risk factor for the high…
View article: Household poverty, schooling, stigma and quality of life in adolescents with epilepsy in rural Uganda
Household poverty, schooling, stigma and quality of life in adolescents with epilepsy in rural Uganda Open
View article: Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo
Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo Open
Nodding syndrome is a highly debilitating, generalized seizure disorder, affecting children in subregions of sub-Saharan Africa. Despite numerous efforts to uncover the etiology, the exact cause of this syndrome still remains obscure. Ther…
View article: The natural history of nodding syndrome
The natural history of nodding syndrome Open
Aims . Nodding syndrome is a poorly understood acquired disorder affecting children in sub‐Saharan Africa. The aetiology and pathogenesis are unknown, and no specific treatment is available. Affected children have a distinctive feature (re…
View article: Issue Information
Issue Information Open
View article: Asymptomatic malaria parasitaemia and seizure control in children with nodding syndrome; a cross-sectional study
Asymptomatic malaria parasitaemia and seizure control in children with nodding syndrome; a cross-sectional study Open
Objective Plasmodium falciparum is epileptogenic and in malaria endemic areas, is a leading cause of acute seizures. In these areas, asymptomatic infections are common but considered benign and so, are not treated. The effects of such infe…
View article: The 2015–2016 malaria epidemic in Northern Uganda; What are the implications for malaria control interventions?
The 2015–2016 malaria epidemic in Northern Uganda; What are the implications for malaria control interventions? Open