Rodrigo Abensur Athanazio
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View article: Cystic fibrosis demographics and healthcare resource utilization in the Brazilian healthcare system
Cystic fibrosis demographics and healthcare resource utilization in the Brazilian healthcare system Open
Objective: To describe the demographic characteristics and hospital healthcare resource utilization (HCRU) in people with cystic fibrosis (CF) in Brazil before the introduction of CF Transmembrane Conductance Regulator modulators, using a …
View article: Trends in clinical and pharmacological profiles of severe asthma in the era of biologics in the Brazilian public health system: real-world evidence from a tertiary outpatient clinic
Trends in clinical and pharmacological profiles of severe asthma in the era of biologics in the Brazilian public health system: real-world evidence from a tertiary outpatient clinic Open
View article: Effect of Dual Bronchodilation on the Exercise Capacity of Individuals With Non-Cystic Fibrosis Bronchiectasis: Protocol for a Randomized Controlled Double-Blind Crossover Study
Effect of Dual Bronchodilation on the Exercise Capacity of Individuals With Non-Cystic Fibrosis Bronchiectasis: Protocol for a Randomized Controlled Double-Blind Crossover Study Open
Background Bronchodilators (BDs) have been used therapeutically to improve exercise capacity in patients with other chronic respiratory diseases. However, the effect of BDs on the exercise capacity of individuals with non-cystic fibrosis b…
View article: Depression and anxiety in adolescents with cystic fibrosis in Brazil: prevalence, stability over time, and relationship with treatment adherence
Depression and anxiety in adolescents with cystic fibrosis in Brazil: prevalence, stability over time, and relationship with treatment adherence Open
Objective: Depression and anxiety have been documented in people with cystic fibrosis (CF), jeopardizing treatment adherence. To date, no studies have assessed the prevalence of psychosocial issues in adolescents with CF in Brazil. We soug…
View article: Regional challenges to optimize the management of patients with severe asthma type 2 inflammation: a Delphi consensus in seven countries
Regional challenges to optimize the management of patients with severe asthma type 2 inflammation: a Delphi consensus in seven countries Open
Conclusions:This Delphi study focused on understanding patients with severe asthma and T2 inflammation in developing/underrepresented countries. Appropriately utilizing biomarkers, timely treatment interventions for best outcomes, e…
View article: Respiratory amyloidosis: a case series from a Brazilian referral center
Respiratory amyloidosis: a case series from a Brazilian referral center Open
View article: Challenges in the treatment of cystic fibrosis in the era of CFTR modulators
Challenges in the treatment of cystic fibrosis in the era of CFTR modulators Open
View article: Analyses of 1236 genotyped primary ciliary dyskinesia individuals identify regional clusters of distinct DNA variants and significant genotype–phenotype correlations
Analyses of 1236 genotyped primary ciliary dyskinesia individuals identify regional clusters of distinct DNA variants and significant genotype–phenotype correlations Open
Background Primary ciliary dyskinesia (PCD) represents a group of rare hereditary disorders characterised by deficient ciliary airway clearance that can be associated with laterality defects. We aimed to describe the underlying gene defect…
View article: Rate of severe exacerbations, healthcare resource utilisation and clinical outcomes in patients with COPD in low-income and middle-income countries: results from the EXACOS International Study
Rate of severe exacerbations, healthcare resource utilisation and clinical outcomes in patients with COPD in low-income and middle-income countries: results from the EXACOS International Study Open
Introduction The EXA cerbations of C hronic obstructive lung disease (COPD) and their O utcome S (EXACOS) International Study aimed to quantify the rate of severe exacerbations and examine healthcare resource utilisation (HCRU) and clinica…
View article: Rheumatoid arthritis-associated airway disease: longitudinal pulmonary function behavior
Rheumatoid arthritis-associated airway disease: longitudinal pulmonary function behavior Open
View article: Use of elexacaftor+tezacaftor+ivacaftor in individuals with cystic fibrosis and at least one F508del allele: a systematic review and meta-analysis
Use of elexacaftor+tezacaftor+ivacaftor in individuals with cystic fibrosis and at least one F508del allele: a systematic review and meta-analysis Open
Objective: To evaluate the effect of treatment with the combination of three cystic fibrosis transmembrane conductance regulator (CFTR) modulators-elexacaftor+tezacaftor+ivacaftor (ETI)-on important clinical endpoints in individuals with c…
View article: A BEAT-PCD consensus statement: a core outcome set for pulmonary disease interventions in primary ciliary dyskinesia
A BEAT-PCD consensus statement: a core outcome set for pulmonary disease interventions in primary ciliary dyskinesia Open
Background Consistent use of reliable and clinically appropriate outcome measures is a priority for clinical trials, with clear definitions to allow comparability. We aimed to develop a core outcome set (COS) for pulmonary disease interven…
View article: Outcomes of Endoscopic Sinus Surgery for Chronic Rhinosinusitis in Adults with Primary Ciliary Dyskinesia
Outcomes of Endoscopic Sinus Surgery for Chronic Rhinosinusitis in Adults with Primary Ciliary Dyskinesia Open
Introduction Primary ciliary dyskinesia (PCD) is a rare inherited disease associated with impairment of mucociliary transport and, consequently, with a high incidence of chronic rhinosinusitis. For patients with chronic rhinosinusitis who …
View article: A real-life study of elexacaftor-tezacaftor-ivacaftor therapy in people with cystic fibrosis in Brazil
A real-life study of elexacaftor-tezacaftor-ivacaftor therapy in people with cystic fibrosis in Brazil Open
View article: Brazilian guidelines for the pharmacological treatment of the pulmonary symptoms of cystic fibrosis. Official document of the Sociedade Brasileira de Pneumologia e Tisiologia (SBPT, Brazilian Thoracic Association)
Brazilian guidelines for the pharmacological treatment of the pulmonary symptoms of cystic fibrosis. Official document of the Sociedade Brasileira de Pneumologia e Tisiologia (SBPT, Brazilian Thoracic Association) Open
Cystic fibrosis (CF) is a genetic disease that results in dysfunction of the CF transmembrane conductance regulator (CFTR) protein, which is a chloride and bicarbonate channel expressed in the apical portion of epithelial cells of various …
View article: Primary Ciliary Dyskinesia Genotypes Vary Markedly Across 19 Countries and Identify Significant Genotype-Phenotype Correlations
Primary Ciliary Dyskinesia Genotypes Vary Markedly Across 19 Countries and Identify Significant Genotype-Phenotype Correlations Open
View article: Is cystic fibrosis a risk factor for COVID-19 infection or related complications?
Is cystic fibrosis a risk factor for COVID-19 infection or related complications? Open
View article: Computed Tomography Evaluation of the Paranasal Sinuses in Adults with Primary Ciliary Dyskinesia
Computed Tomography Evaluation of the Paranasal Sinuses in Adults with Primary Ciliary Dyskinesia Open
Introduction Primary ciliary dyskinesia is a rare inherited disease that results in a malfunction of mucociliary clearance and sinonasal complaints. Aplasia/hypoplasia of the frontal and sphenoid sinuses has been described as more frequent…
View article: In-person and online application of the Bronchiectasis Health Questionnaire: are they interchangeable?
In-person and online application of the Bronchiectasis Health Questionnaire: are they interchangeable? Open
View article: Prevalence of the eosinophilic phenotype among severe asthma patients in Brazil: the BRAEOS study
Prevalence of the eosinophilic phenotype among severe asthma patients in Brazil: the BRAEOS study Open
Objective: To assess the prevalence of the eosinophilic and allergic phenotypes of severe asthma in Brazil, as well as to investigate the clinical characteristics of severe asthma patients in the country. Methods: This was a cross-sectiona…
View article: Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study
Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study Open
View article: Brazilian Guidelines for Nutrition in Cystic Fibrosis
Brazilian Guidelines for Nutrition in Cystic Fibrosis Open
This work enabled establishing a scientific consensus for nutritional treatment of cystic fibrosis patients.
View article: Brazilian Guidelines for Nutrition in Cystic Fibrosis
Brazilian Guidelines for Nutrition in Cystic Fibrosis Open
Objective To develop a scientific consensus on nutrition in cystic fibrosis. Methods Sixteen coordinators elaborated relevant questions on nutritional therapy in cystic fibrosis, which were divided into six sections: nutritional assessment…
View article: Direct Oral Anticoagulants for the Treatment of Cancer-Associated Venous Thromboembolism: A Latin American Perspective
Direct Oral Anticoagulants for the Treatment of Cancer-Associated Venous Thromboembolism: A Latin American Perspective Open
Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in patients with cancer. On the basis of results from randomized controlled trials, direct oral anticoagulants (DOACs) are now recommended for the treatment of canc…
View article: Persistent Airflow Obstruction: A Marker of a Severe Asthma Cohort – Inflammatory, Functional and Pathological Features
Persistent Airflow Obstruction: A Marker of a Severe Asthma Cohort – Inflammatory, Functional and Pathological Features Open
In our previous severe asthma cohort, 82% had fixed obstruction. Although they had greater airway smooth muscle area with decreased periostin, inflammation and remodeling weren’t associated with symptom control. High-resolution computed to…
View article: Bronchiectasis: moving from an orphan disease to an unpleasant socioeconomic burden
Bronchiectasis: moving from an orphan disease to an unpleasant socioeconomic burden Open
Bronchiectasis has received increasing attention in recent years. At the same time, studies have shown a high incidence of this disease, especially in older populations, associated with high health-related costs and economic burden.…
View article: Exercise-induced desaturation in subjects with non-cystic fibrosis bronchiectasis: laboratory-based tests versus field-based exercise tests
Exercise-induced desaturation in subjects with non-cystic fibrosis bronchiectasis: laboratory-based tests versus field-based exercise tests Open
Field exercise tests showed good precision to detect desaturation. Field tests might be an alternative to laboratory tests when the clinical question is to investigate exercise-induced desaturation in subjects with bronchiectasis.
View article: Home-based pulmonary rehabilitation in people with bronchiectasis: a randomised controlled trial
Home-based pulmonary rehabilitation in people with bronchiectasis: a randomised controlled trial Open
Aim To investigate the short- and long-term effects of home-based pulmonary rehabilitation (HBPR) on functional capacity, quality of life, peripheral muscle strength, dyspnoea and daily physical activity in people with bronchiectasis. Meth…
View article: Automated Computed Tomography Lung Densitometry in Bronchiectasis Patients
Automated Computed Tomography Lung Densitometry in Bronchiectasis Patients Open
Rationale: Bronchiectasis is a complex and heterogeneous disease. Visual computed tomography (CT) scoring systems are used to assess disease severity, disease progression and predict outcomes in bronchiectasis although they have some limit…
View article: What is the optimal large airway size reduction value to determine malacia: exploratory bronchoscopic analysis in patients in Mounier-Kuhn syndrome
What is the optimal large airway size reduction value to determine malacia: exploratory bronchoscopic analysis in patients in Mounier-Kuhn syndrome Open