Roger D. Kamm
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View article: A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment
A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment Open
Systemic inflammation associated with obesity impairs skeletal muscle function through paracrine signaling from intermuscular adipose tissue—adipose depots situated between adjacent skeletal muscle groups—as well as from visceral adipose t…
View article: Long-term physiological flow rescues regressed microvascular networks and increases their longevity
Long-term physiological flow rescues regressed microvascular networks and increases their longevity Open
View article: ETV2 mediated differentiation of human pluripotent stem cells results in functional endothelial cells for engineering advanced vascularized microphysiological models
ETV2 mediated differentiation of human pluripotent stem cells results in functional endothelial cells for engineering advanced vascularized microphysiological models Open
Patient-specific microphysiological models, exemplified by organs-on-a-chip and organoids, have become a valuable tool for broad applications, revolutionizing biomedical research. However, limitations persist, with functional vasculature b…
View article: 3D printing and bioprinting for miniaturized and scalable hanging-drop organoids culture
3D printing and bioprinting for miniaturized and scalable hanging-drop organoids culture Open
Three-dimensional (3D) cell culture systems rely on the manipulation of a biologically derived matrix, typically soluble Basement Membrane Extract (sBME), in which cells or cellular aggregates, such as organoids, are suspended. This matrix…
View article: BS02 Developing a human 3D self-organised microvascular model to understand the pathological effect of hyperglycaemia on blood-brain barrier integrity
BS02 Developing a human 3D self-organised microvascular model to understand the pathological effect of hyperglycaemia on blood-brain barrier integrity Open
View article: Mechanobiology of the blood-brain barrier during development, disease and ageing
Mechanobiology of the blood-brain barrier during development, disease and ageing Open
View article: Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research
Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research Open
Aging is a complex process and the main risk factor for many common human diseases. Traditional aging research using short‐lived animal models and two‐dimensional cell cultures has led to key discoveries, but their relevance to human aging…
View article: Remodeling of self-assembled microvascular networks under long term flow
Remodeling of self-assembled microvascular networks under long term flow Open
The incorporation of a functional perfusable microvascular network (MVN) is a common requirement for most organ on-chip-models. Long-term perfusion of MVNs is often required for the maturation of organ phenotypes and disease pathologies an…
View article: A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis
A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis Open
View article: Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion
Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion Open
Metastasis, the leading cause of cancer-related deaths, involves a complex cascade of events, including extravasation. Despite extensive research into metastasis, the mechanisms underlying extravasation remain unclear. Molecular targeted t…
View article: Myofibroblasts reduce angiogenesis and vasculogenesis in a vascularized microphysiological model of lung fibrosis
Myofibroblasts reduce angiogenesis and vasculogenesis in a vascularized microphysiological model of lung fibrosis Open
Lung fibrosis, characterized by chronic and progressive scarring, has no cure. Hallmarks are the accumulation of myofibroblasts and extracellular matrix, as well as vascular remodeling. The crosstalk between myofibroblasts and vasculature …
View article: SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection
SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection Open
View article: Deep and dynamic metabolic and structural imaging in living tissues
Deep and dynamic metabolic and structural imaging in living tissues Open
Label-free imaging through two-photon autofluorescence of NAD(P)H allows for nondestructive, high-resolution visualization of cellular activities in living systems. However, its application to thick tissues has been restricted by its limit…
View article: miR126-mediated impaired vascular integrity in Rett syndrome
miR126-mediated impaired vascular integrity in Rett syndrome Open
Rett syndrome (RTT) is a neurodevelopmental disorder that is caused by mutations in melty-CpG binding protein 2 (MeCP2). MeCP2 is a non-cell type-specific DNA binding protein, and its mutation influences not only neural cells but also non-…
View article: Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor (Adv. Sci. 38/2024)
Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor (Adv. Sci. 38/2024) Open
Vascularized Patient‐Derived Tumoroid Confocal microscopy image of a patient‐derived tumoroid, vascularized by perfusable microvascular networks in a microfluidic device. In article number 2402757, Giovanni S. Offeddu, Elena Cambria, Charl…
View article: VONet: A deep learning network for 3D reconstruction of organoid structures with a minimal number of confocal images
VONet: A deep learning network for 3D reconstruction of organoid structures with a minimal number of confocal images Open
Organoids and 3D imaging techniques are crucial for studying human tissue structure and function, but traditional 3D reconstruction methods are expensive and time consuming, relying on complete z stack confocal microscopy data. This paper …
View article: A vascularized human lung-on-a-chip reveals compartmentalized inflammatory responses in bacterial pneumonia
A vascularized human lung-on-a-chip reveals compartmentalized inflammatory responses in bacterial pneumonia Open
The lung serves as a primary organ for gas exchange in the human body. However, during clinically apparent lung insults such as bacterial pneumonia, the blood-alveolar barrier is disrupted, immune cells are recruited, and lung biomechanics…
View article: Utilizing convolutional neural networks for discriminating cancer and stromal cells in three-dimensional cell culture images with nuclei counterstain
Utilizing convolutional neural networks for discriminating cancer and stromal cells in three-dimensional cell culture images with nuclei counterstain Open
This study introduces a non-invasive toxicity-free approach to 3D cell culture evaluation, combining machine learning with confocal microscopy, opening avenues for advanced cell studies.
View article: Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor
Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor Open
Desmoplasia in breast cancer leads to heterogeneity in physical properties of the tissue, resulting in disparities in drug delivery and treatment efficacy among patients, thus contributing to high disease mortality. Personalized in vitro b…
View article: Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion
Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion Open
Metastasis, the leading cause of cancer-related deaths, involves a complex cascade of events, including extravasation. Despite extensive research into metastasis, the mechanisms underlying extravasation remain unclear. Molecular targeted t…
View article: Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology
Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology Open
Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing a significant global health challenge as well as a high socioeconomic burden. With aging constituting one of the main risk factors for some NDDs such as…
View article: DIPG-08. PROBING THE BLOOD-BRAIN-TUMOR-BARRIER WITH A MICROVASCULAR MODEL OF DIFFUSE MIDLINE GLIOMA
DIPG-08. PROBING THE BLOOD-BRAIN-TUMOR-BARRIER WITH A MICROVASCULAR MODEL OF DIFFUSE MIDLINE GLIOMA Open
BACKGROUND Pediatric diffuse midline glioma (DMG) is a uniformly fatal brain tumor in children, with most patients surviving less than 12 months. Current treatment for DMG is limited, and outcomes for this tumor have not improved. The bloo…
View article: Transmural Flow Upregulates PD‐L1 Expression in Microvascular Networks
Transmural Flow Upregulates PD‐L1 Expression in Microvascular Networks Open
Endothelial programmed death‐ligand 1 (PD‐L1) expression is higher in tumors than in normal tissues. Also, tumoral vasculatures tend to be leakier than normal vessels leading to a higher trans‐endothelial or transmural fluid flow. However,…
View article: Deep and Dynamic Metabolic and Structural Imaging in Living Tissues
Deep and Dynamic Metabolic and Structural Imaging in Living Tissues Open
Label-free imaging through two-photon autofluorescence (2PAF) of NAD(P)H allows for non-destructive and high-resolution visualization of cellular activities in living systems. However, its application to thick tissues and organoids has bee…
View article: Ether lipids influence cancer cell fate by modulating iron uptake
Ether lipids influence cancer cell fate by modulating iron uptake Open
Cancer cell fate has been widely ascribed to mutational changes within protein-coding genes associated with tumor suppressors and oncogenes. In contrast, the mechanisms through which the biophysical properties of membrane lipids influence …
View article: Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip
Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip Open
View article: Linking cell mechanical memory and cancer metastasis
Linking cell mechanical memory and cancer metastasis Open
View article: Microfluidic‐Based Reconstitution of Functional Lymphatic Microvasculature: Elucidating the Role of Lymphatics in Health and Disease
Microfluidic‐Based Reconstitution of Functional Lymphatic Microvasculature: Elucidating the Role of Lymphatics in Health and Disease Open
The knowledge of the blood microvasculature and its functional role in health and disease has grown significantly attributable to decades of research and numerous advances in cell biology and tissue engineering; however, the lymphatics (th…
View article: Patient-Specific Vascularized Tumor Model: Blocking TAM Recruitment with Multispecific Antibodies Targeting CCR2 and CSF-1R
Patient-Specific Vascularized Tumor Model: Blocking TAM Recruitment with Multispecific Antibodies Targeting CCR2 and CSF-1R Open
Tumor-associated inflammation drives cancer progression and therapy resistance, with the infiltration of monocyte-derived tumor-associated macrophages (TAMs) associated with poor prognosis in diverse cancers. Targeting TAMs holds potential…