Roger J. Davis
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JNK3 regulates β cell responses to incretins in human islets and mouse models Open
The c-Jun N-terminal kinases (JNKs) regulate diverse physiological processes. Whereas JNK1 and JNK2 are broadly expressed and associated with insulin resistance, inflammation, and stress responses, JNK3 is largely restricted to central ner…
View article: Adipocyte MKK3 Increases in Human Obesity protecting against Insulin Resistance by p38β activation
Adipocyte MKK3 Increases in Human Obesity protecting against Insulin Resistance by p38β activation Open
Summary Obesity is a major global health concern, and a key predisposing factor for insulin resistance and type 2 diabetes mellitus. Adipocytes play a critical role in the development of obesity-induced insulin resistance, with several sig…
View article: Bipartite binding of the intrinsically disordered scaffold protein JIP1 to the kinase JNK1
Bipartite binding of the intrinsically disordered scaffold protein JIP1 to the kinase JNK1 Open
Scaffold proteins are key players in many signaling pathways where they ensure spatial and temporal control of molecular interactions by simultaneous tethering of multiple signaling components. The protein JIP1 acts as a scaffold within th…
View article: The structural basis of protective and nonprotective human monoclonal antibodies targeting the parainfluenza virus type 3 hemagglutinin-neuraminidase
The structural basis of protective and nonprotective human monoclonal antibodies targeting the parainfluenza virus type 3 hemagglutinin-neuraminidase Open
Parainfluenza virus 3 (PIV3) infection poses a substantial risk to vulnerable groups including infants, the elderly, and immunocompromised individuals, and lacks effective treatments or vaccines. This study focuses on targeting the hemaggl…
View article: G12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis
G12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis Open
Altered hepatic glucose fluxes are critical during the pathogenesis of type 2 diabetes. G protein-coupled receptors represent important regulators of hepatic glucose production. Recent studies have shown that hepatocytes express GPCRs that…
Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity Open
Coordination of adaptive metabolism through cellular signaling networks and metabolic response is essential for balanced flow of energy and homeostasis. Post-translational modifications such as phosphorylation offer a rapid, efficient, and…
eLife Assessment: E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation Open
The Wnt/Wg pathway controls myriads of biological phenomena throughout the development and adult life of all organisms across the phyla. Thus, an aberrant Wnt signaling is associated with a wide range of pathologies in humans. Tight regula…
eLife assessment: Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit Open
Full text Figures and data Side by side Abstract eLife assessment eLife digest Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Metrics Abstract C…
eLife Assessment: Identification of CD133+ Intercellsomes in Intercellular Communication to Offset Intracellular Signal Deficit Open
CD133 (prominin 1) is widely viewed as a cancer stem cell marker in association with drug resistance and cancer recurrence. Herein we report that with impaired RTK-Shp2 Ras-Erk signaling, heterogenous hepatocytes form clusters that manage …
Reviewer #2 (Public Review): E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation Open
The Wnt/Wg pathway controls myriads of biological phenomena throughout the development and adult life of all organisms across the phyla. Thus, an aberrant Wnt signaling is associated with a wide range of pathologies in humans. Tight regula…
eLife Assessment: E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation Open
The Wnt/Wg pathway controls myriads of biological phenomena throughout the development and adult life of all organisms across the phyla. Thus, an aberrant Wnt signaling is associated with a wide range of pathologies in humans. Tight regula…
eLife assessment: Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Abstract Posttranslational modi…
eLife Assessment: Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer Open
Posttranslational modifications of epigenetic modifiers provide a flexible and timely mechanism for rapid adaptations to the dynamic environment of cancer cells. SIRT1 is an NAD+-dependent epigenetic modifier whose activity is classically …
Reviewer #2 (Public Review): Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer Open
Posttranslational modifications of epigenetic modifiers provide a flexible and timely mechanism for rapid adaptations to the dynamic environment of cancer cells. SIRT1 is an NAD+-dependent epigenetic modifier whose activity is classically …
eLife Assessment: Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer Open
Posttranslational modifications of epigenetic modifiers provide a flexible and timely mechanism for rapid adaptations to the dynamic environment of cancer cells. SIRT1 is an NAD+-dependent epigenetic modifier whose activity is classically …
eLife Assessment: Intercellular Communication Compensates Intracellular Proliferative Signal Deficit during Liver Regeneration Open
It remains to be determined how cells strive to proliferate under proliferative signal deficit. Herein we report that with impaired RTK-Shp2-Ras-Erk signaling, heterogenous hepatocytes formed clusters to divide during liver regeneration. T…
Supplementary Figure 5 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer Open
PDF file - 484K, Evaluation of the contribution of FOXO1 to NRP2 expression
Supplementary Figure 1 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer Open
PDF file - 536K, Invasive behavior of cell lines used and assessment of NRP2 expression in prostate glands and cancer
Supplementary Figure 3 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer Open
PDF file - 582K, Analysis of NRP2, IGF-1R and p-AKT in consecutive sections of prostate cancer specimens
Supplementary Figure 2 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer Open
PDF file - 2.5MB, Correlation of NRP2 expression in prostate cancer with clinical parameters and expression of VEGFRs
Supplementary Figure 8 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer Open
PDF file - 819K, List of primer sequences for semi-quantitative and quantitative PCR