Roger Lecomte
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View article: CT-scan assessment of lung volumes and effect of gravity on lung ventilation during and after total liquid ventilation in piglets
CT-scan assessment of lung volumes and effect of gravity on lung ventilation during and after total liquid ventilation in piglets Open
Total liquid ventilation (TLV) offers hope for helping nano-preterm infants adapt to the extrauterine environment at birth. We aimed to test whether lung volumes could be maintained over time during TLV and whether the prone position alter…
View article: Development, validation, and preliminary phenotypic characterization of a <i>Col6a3</i> knockout mouse model targeting exon 3
Development, validation, and preliminary phenotypic characterization of a <i>Col6a3</i> knockout mouse model targeting exon 3 Open
Background Most mutations in the COL6A3 gene lead to collagen VI‐related myopathies. This is due to a reduced expression or mislocalization of the COL6A3 protein. Therefore, studying the consequence of knocking out the Col6a3 gene in mouse…
View article: On the implementation of acollinearity in PET Monte Carlo simulations
On the implementation of acollinearity in PET Monte Carlo simulations Open
Objective. Acollinearity of annihilation photons (APA) introduces spatial blur in positron emission tomography (PET) imaging. This phenomenon increases proportionally with the scanner diameter and it has been shown to follow a Gaussian dis…
View article: Deep-learning-derived input function in dynamic [18F]FDG PET imaging of mice
Deep-learning-derived input function in dynamic [18F]FDG PET imaging of mice Open
Dynamic positron emission tomography and kinetic modeling play a critical role in tracer development research using small animals. Kinetic modeling from dynamic PET imaging requires accurate knowledge of an input function, ideally determin…
View article: Enhanced Extraction of Blood and Tissue Time-Activity Curves in Cardiac Mouse FDG PET Imaging by Means of Constrained Nonnegative Matrix Factorization
Enhanced Extraction of Blood and Tissue Time-Activity Curves in Cardiac Mouse FDG PET Imaging by Means of Constrained Nonnegative Matrix Factorization Open
We propose an enhanced method to accurately retrieve time-activity curves (TACs) of blood and tissue from dynamic 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) cardiac images of mice. The method is noninvasi…
View article: Timing Estimation and Limits in TOF-PET Detectors Producing Prompt Photons
Timing Estimation and Limits in TOF-PET Detectors Producing Prompt Photons Open
The production of prompt photons providing high photon time densities is a promising avenue to reach ultrahigh coincidence time resolution (CTR) in time-of-flight PET. Detectors producing prompt photons are receiving high interest experime…
View article: A rewriting of the relation between the acolinearity of annihilation photons and their energy in the context of positron emission tomography
A rewriting of the relation between the acolinearity of annihilation photons and their energy in the context of positron emission tomography Open
Acolinearity of the annihilation photons observed in Positron Emission Tomography (PET) is described as following a Gaussian distribution. However, it is never explicitly said if it refers to the amplitude of the acolinearity angle or its …
View article: Estimation of the Internal Dose Imparted by 18F-Fluorodeoxyglucose to Tissues by Using Fricke Dosimetry in a Phantom and Positron Emission Tomography
Estimation of the Internal Dose Imparted by 18F-Fluorodeoxyglucose to Tissues by Using Fricke Dosimetry in a Phantom and Positron Emission Tomography Open
Purpose Assessment of the radiation dose delivered to a tumor and different organs is a major issue when using radiolabelled compounds for diagnostic imaging or endoradiotherapy. The present article reports on a study to correlate the mean…
View article: The ultra high sensitivity blood counter: a compact, MRI-compatible, radioactivity counter for pharmacokinetic studies in μl volumes
The ultra high sensitivity blood counter: a compact, MRI-compatible, radioactivity counter for pharmacokinetic studies in μl volumes Open
Quantification of physiological parameters in preclinical pharmacokinetic studies based on nuclear imaging requires the monitoring of arterial radioactivity over time, known as the arterial input function (AIF). Continuous derivation of th…
View article: Parameterizing the Angular Distribution of Emission: A Model for TOF-PET Low-Count Reconstruction
Parameterizing the Angular Distribution of Emission: A Model for TOF-PET Low-Count Reconstruction Open
Low-count reconstruction remains a challenge for Positron Emission Tomography (PET) even with the recent progress in time-of-flight (TOF) resolution. In this context, the bias between the acquired histogram, consisting of low values or zer…
View article: Parameterizing the Angular Distribution of Emission: A model for TOF-PET low counts reconstruction
Parameterizing the Angular Distribution of Emission: A model for TOF-PET low counts reconstruction Open
Low counts reconstruction remains a challenge for Positron Emission Tomography (PET) even with the recent progresses in time-of-flight (TOF) resolution. In that setting, the bias between the acquired histogram, composed of low values or ze…
View article: Investigation of a Model-Based Time-Over-Threshold Technique for Phoswich Crystal Discrimination
Investigation of a Model-Based Time-Over-Threshold Technique for Phoswich Crystal Discrimination Open
The best crystal identification (CI) algorithms proposed so far for phoswich detectors are based on adaptive filtering and pulse shape discrimination (PSD). However, these techniques require free running analog to digital converters, which…
View article: DOI estimation through signal arrival time distribution: a theoretical description including proof of concept measurements
DOI estimation through signal arrival time distribution: a theoretical description including proof of concept measurements Open
The challenge to reach 10 ps coincidence time resolution (CTR) in time-of-flight positron emission tomography (TOF-PET) is triggering major efforts worldwide, but timing improvements of scintillation detectors will remain elusive without d…
View article: Performance evaluation of the mouse version of the LabPET II PET scanner
Performance evaluation of the mouse version of the LabPET II PET scanner Open
The LabPET II is a new positron emission tomography technology platform designed to achieve submillimetric spatial resolution imaging using fully pixelated avalanche photodiodes-based detectors and highly integrated parallel front-end proc…
View article: Improvement of Spatial Resolution With Iterative PET Reconstruction Using Ultrafast TOF
Improvement of Spatial Resolution With Iterative PET Reconstruction Using Ultrafast TOF Open
The impact of Time-of-Flight (TOF) on positron emission tomography (PET) spatial resolution is generally considered negligible. In this work, a two-step approach based on simulations of two-dimensional scanner configurations is taken to sh…
View article: Performance investigation of LabPET II detector technology in an MRI-like environment
Performance investigation of LabPET II detector technology in an MRI-like environment Open
The EMI-compatibility of the LabPET II detection module (DM) to develop a high-resolution simultaneous PET/MRI system is investigated. The experimental set-up evaluates the performance of two LabPET II DMs in close proximity to RF coils ex…
View article: Performance Simulation of an Ultrahigh Resolution Brain PET Scanner Using 1.2-mm Pixel Detectors
Performance Simulation of an Ultrahigh Resolution Brain PET Scanner Using 1.2-mm Pixel Detectors Open
The concept of a new ultra-high resolution positron emission tomography (PET) brain scanner featuring truly pixelated detectors based on the LabPET II technology is presented. The aim of this study is to predict the performance of the scan…
View article: Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction
Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction Open
Chymase, a mast cell serine protease involved in the generation of multiple cardiovascular factors, such as angiotensin II and endothelin-1 (ET-1), is elevated and participates in tissue degeneration after permanent myocardial infarction (…
View article: Interscapular brown adipose tissue denervation does not promote the oxidative activity of inguinal white adipose tissue in male mice
Interscapular brown adipose tissue denervation does not promote the oxidative activity of inguinal white adipose tissue in male mice Open
Brown adipose tissue (BAT) thermogenesis is a key controller of energy metabolism. In response to cold or other adrenergic stimuli, brown adipocytes increase their substrate uptake and oxidative activity while uncoupling ATP synthesis from…