Roger Marchant
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View article: The Application of Glycolipid-Type Microbial Biosurfactants as Active Pharmaceutical Ingredients for the Treatment and Prevention of Cancer
The Application of Glycolipid-Type Microbial Biosurfactants as Active Pharmaceutical Ingredients for the Treatment and Prevention of Cancer Open
Pharmaceutical scientists have researched the potential of secondary metabolites biosynthesized by microorganisms as active pharmaceutical ingredients (APIs) for the treatment of cancer. Ideally, these APIs should possess anticancer bioact…
View article: Purified Acidic Sophorolipid Biosurfactants in Skincare Applications: An Assessment of Cytotoxic Effects in Comparison with Synthetic Surfactants Using a 3D In Vitro Human Skin Model
Purified Acidic Sophorolipid Biosurfactants in Skincare Applications: An Assessment of Cytotoxic Effects in Comparison with Synthetic Surfactants Using a 3D In Vitro Human Skin Model Open
Acidic sophorolipids (Acidic SL), congeners of sophorolipid biosurfactants, offer a potential alternative to synthetic sodium lauryl ether sulphate (SLES) in skincare applications. However, major challenges associated with the laboratory-b…
View article: Glycolipid Biosurfactants in Skincare Applications: Challenges and Recommendations for Future Exploitation
Glycolipid Biosurfactants in Skincare Applications: Challenges and Recommendations for Future Exploitation Open
The 21st century has seen a substantial increase in the industrial applications of glycolipid biosurfactant technology. The market value of the glycolipid class of molecules, sophorolipids, was estimated to be USD 409.84 million in 2021, w…
View article: Mono-Rhamnolipid Biosurfactants Synthesized by Pseudomonas aeruginosa Detrimentally Affect Colorectal Cancer Cells
Mono-Rhamnolipid Biosurfactants Synthesized by Pseudomonas aeruginosa Detrimentally Affect Colorectal Cancer Cells Open
Over the past 15 years, glycolipid-type biosurfactant compounds have been postulated as novel, naturally synthesized anticancer agents. This study utilized a recombinant strain of Pseudomonas aeruginosa to biosynthesize a preparation of mo…
View article: Characterisation of cytotoxicity and immunomodulatory effects of glycolipid biosurfactants on human keratinocytes
Characterisation of cytotoxicity and immunomodulatory effects of glycolipid biosurfactants on human keratinocytes Open
View article: Biogenic propane production by a marine Photobacterium strain isolated from the Western English Channel
Biogenic propane production by a marine Photobacterium strain isolated from the Western English Channel Open
Propane is a major component of liquefied petroleum gas, a major energy source for off-grid communities and industry. The replacement of fossil fuel-derived propane with more sustainably derived propane is of industrial interest. One poten…
View article: Multi-method biophysical analysis in discovery, identification, and in-depth characterization of surface‐active compounds
Multi-method biophysical analysis in discovery, identification, and in-depth characterization of surface‐active compounds Open
Synthetic surfactants are used in several industries, including manufacturing, pharmaceutical and cosmetic’s, food and feed, agriculture, petroleum and environmental remediation for their ability to adsorb to fluid and solid-water interfac…
View article: Microbial sophorolipids inhibit colorectal tumour cell growth in vitro and restore haematocrit in Apcmin+/− mice
Microbial sophorolipids inhibit colorectal tumour cell growth in vitro and restore haematocrit in Apcmin+/− mice Open
Sophorolipids are glycolipid biosurfactants consisting of a carbohydrate sophorose head with a fatty acid tail and exist in either an acidic or lactonic form. Sophorolipids are gaining interest as potential cancer chemotherapeutics due to …
View article: Biosurfactants as Anticancer Agents: Glycolipids Affect Skin Cells in a Differential Manner Dependent on Chemical Structure
Biosurfactants as Anticancer Agents: Glycolipids Affect Skin Cells in a Differential Manner Dependent on Chemical Structure Open
Melanomas account for 80% of skin cancer deaths. Due to the strong relationship between melanomas and U.V. radiation, sunscreens have been recommended for use as a primary preventative measure. However, there is a need for targeted, less i…
View article: Pseudomonas aeruginosa PA80 is a cystic fibrosis isolate deficient in RhlRI quorum sensing
Pseudomonas aeruginosa PA80 is a cystic fibrosis isolate deficient in RhlRI quorum sensing Open
View article: Microbial biosurfactant research: time to improve the rigour in the reporting of synthesis, functional characterization and process development
Microbial biosurfactant research: time to improve the rigour in the reporting of synthesis, functional characterization and process development Open
Summary The demand for microbially produced surface‐active compounds for use in industrial processes and products is increasing. As such, there has been a comparable increase in the number of publications relating to the characterization o…
View article: Microbial Biosurfactants in Cosmetic and Personal Skincare Pharmaceutical Formulations
Microbial Biosurfactants in Cosmetic and Personal Skincare Pharmaceutical Formulations Open
Cosmetic and personal care products are globally used and often applied directly on the human skin. According to a recent survey in Europe, the market value of cosmetic and personal care products in Western Europe reached about 84 billion …
View article: Biosynthesis of rhamnolipid by a Marinobacter species expands the paradigm of biosurfactant synthesis to a new genus of the marine microflora
Biosynthesis of rhamnolipid by a Marinobacter species expands the paradigm of biosurfactant synthesis to a new genus of the marine microflora Open
View article: The marine environment: a promising source of microorganisms for the production of biosurfactants
The marine environment: a promising source of microorganisms for the production of biosurfactants Open
Marine organisms have developed strategies to cope with specialised environmental conditions. One common strategy is the production of biosurfactant molecules to access specific nutrients and to promote biofilm development. In this study, …
View article: The Riddle of Rhamnolipid Molecular Biosynthesis
The Riddle of Rhamnolipid Molecular Biosynthesis Open
Rhamnolipids (RL) were first shown to be produced by the opportunistic pathogen Pseudomonas aeruginosa. RL production is achieved via a biosynthesis pathway comprising three separate enzymes; RhlA, responsible for the synthesis of the fatt…
View article: Characterisation of rhamnolipid production in a previously un-investigated, non-pathogenic marine Pseudomonad.
Characterisation of rhamnolipid production in a previously un-investigated, non-pathogenic marine Pseudomonad. Open
This study identifies, for the first time a significantly high level of synthesis of short chain di-rhamnolipids by a non-pathogenic marine Pseudomonas species. Pseudomonas sp. MCTG214(3b1) was isolated from a phytoplankton bloom of the co…
View article: Quorum sensing as a potential target for increased production of rhamnolipid biosurfactant in Burkholderia thailandensis E264
Quorum sensing as a potential target for increased production of rhamnolipid biosurfactant in Burkholderia thailandensis E264 Open
View article: Natural quorum sensing inhibitors effectively downregulate gene expression of Pseudomonas aeruginosa virulence factors
Natural quorum sensing inhibitors effectively downregulate gene expression of Pseudomonas aeruginosa virulence factors Open
View article: Microbial biosurfactants: current trends and applications in agricultural and biomedical industries
Microbial biosurfactants: current trends and applications in agricultural and biomedical industries Open
Synthetic surfactants are becoming increasingly unpopular in many applications due to previously disregarded effects on biological systems and this has led to a new focus on replacing such products with biosurfactants that are biodegradabl…
View article: Surfactants from the sea: rhamnolipid production by marine bacteria
Surfactants from the sea: rhamnolipid production by marine bacteria Open
Biosurfactants produced from microbial sources are increasingly viewed by industry as more sustainable and less toxic alternatives to their chemically derived counterparts. One major class of biosurfactant that has the potential for commer…
View article: New floristic records in the Balkans: 37, Reports 149-183
New floristic records in the Balkans: 37, Reports 149-183 Open
View article: The performance of surfactant mixtures at low temperatures
The performance of surfactant mixtures at low temperatures Open
View article: Marine derived biosurfactants: a vast potential future resource
Marine derived biosurfactants: a vast potential future resource Open
Surfactants and emulsifiers are surface-active compounds (SACs) which play an important role in various industrial processes and products due to their interfacial properties. Many of the chemical surfactants in use today are produced from …
View article: Identification and characterisation of short chain rhamnolipid production in a previously uninvestigated, non-pathogenic marine pseudomonad
Identification and characterisation of short chain rhamnolipid production in a previously uninvestigated, non-pathogenic marine pseudomonad Open
This study aimed to identify and characterise biosurfactant compounds produced by bacteria associated with a marine eukaryotic phytoplankton bloom. One strain, designated MCTG214(3b1), was isolated by enrichment with polycyclic aromatic hy…
View article: Fatty acid synthesis pathway provides lipid precursors for rhamnolipid biosynthesis in Burkholderia thailandensis E264
Fatty acid synthesis pathway provides lipid precursors for rhamnolipid biosynthesis in Burkholderia thailandensis E264 Open
View article: Going Green and Cold: Biosurfactants from Low-Temperature Environments to Biotechnology Applications
Going Green and Cold: Biosurfactants from Low-Temperature Environments to Biotechnology Applications Open
Approximately 80% of the Earth's biosphere is cold, at an average temperature of 5°C, and is populated by a diversity of microorganisms that are a precious source of molecules with high biotechnological potential. Biosurfactants from cold-…
View article: Enhanced rhamnolipid production in Burkholderia thailandensis transposon knockout strains deficient in polyhydroxyalkanoate (PHA) synthesis
Enhanced rhamnolipid production in Burkholderia thailandensis transposon knockout strains deficient in polyhydroxyalkanoate (PHA) synthesis Open
View article: Rhamnolipids and lactonic sophorolipids: natural antimicrobial surfactants for oral hygiene
Rhamnolipids and lactonic sophorolipids: natural antimicrobial surfactants for oral hygiene Open
The findings indicate the potential value of biosurfactants for both oral hygiene and the pharmaceutical industries since there is a serious need to reduce the reliance on synthetic antimicrobials and antibiotics.
View article: Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens
Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens Open
View article: Microbial rhamnolipid production: a critical re-evaluation of published data and suggested future publication criteria
Microbial rhamnolipid production: a critical re-evaluation of published data and suggested future publication criteria Open
High production cost and potential pathogenicity of Pseudomonas aeruginosa, commonly used for rhamnolipid synthesis, have led to extensive research for safer producing strains and cost-effective production methods. This has resulted in num…