Maike Richter
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Prioritizing clinical data for psychiatric inpatient dashboards: insights from a nationwide survey of German university centers Open
Introduction As digital data collection becomes increasingly integrated into the treatment of patients with affective disorders, the use of dashboards to visualize this information for clinicians is gaining importance. However, the questio…
View article: Symptom trajectories and their predictive factors in psychiatric inpatients with depression
Symptom trajectories and their predictive factors in psychiatric inpatients with depression Open
Our findings highlight reproducible inpatient symptom trajectories shaped by shared risk factors and the potential of longitudinal phenotyping to guide individualized care in depression.
View article: Scalable depression monitoring with smartphone speech: a multimodal benchmark and topic analysis
Scalable depression monitoring with smartphone speech: a multimodal benchmark and topic analysis Open
Objective, scalable biomarkers are needed for continuous monitoring of major depressive disorder (MDD). Smartphone-collected speech is promising, yet extracting clinically useful signals remains difficult. We analysed 3 151 weekly voice di…
View article: Childhood maltreatment’s influence on the dynamic course of depression: symptom trajectories during inpatient treatment and after discharge
Childhood maltreatment’s influence on the dynamic course of depression: symptom trajectories during inpatient treatment and after discharge Open
Background Many studies have highlighted the detrimental effect of childhood maltreatment (CM) on depression severity and the course of illness in major depressive disorder (MDD). Yet our understanding of how CM influences the dynamic symp…
View article: Judged by your neighbors: Brain structural normativity profiles for large and heterogeneous samples
Judged by your neighbors: Brain structural normativity profiles for large and heterogeneous samples Open
The detection of norm deviations is fundamental to clinical decision making and impacts our ability to diagnose and treat diseases effectively. Current normative modeling approaches rely on generic comparisons and quantify deviations in re…
Gray matter correlates of childhood maltreatment: searching for replicability in a multi-cohort brain-wide association study Open
Childhood maltreatment effects on cerebral gray matter have been frequently discussed as a neurobiological pathway for depression. However, localizations are highly heterogeneous, and recent reports have questioned the replicability of men…
Generalizability of Clinical Prediction Models in Mental Health - Real-World Validation of Machine Learning Models for Depressive Symptom Prediction Open
Mental health research faces the challenge of developing machine learning models for clinical decision support. Concerns about the generalizability of such models to real-world populations due to sampling effects and disparities in availab…
Narcissistic dimensions and depressive symptoms in patients across mental disorders in cognitive behavioural therapy and in psychoanalytic interactional therapy in Germany: a prospective cohort study Open
For the German translation of the abstract see Supplementary Materials section.
Higher body weight-dependent neural activation during reward processing Open
Obesity is associated with alterations in brain structure and function, particularly in areas related to reward processing. Although brain structural investigations have demonstrated a continuous association between higher body weight and …
View article: Cross-validation for the estimation of effect size generalizability in mass-univariate brain-wide association studies
Cross-validation for the estimation of effect size generalizability in mass-univariate brain-wide association studies Open
Introduction Statistical effect sizes are systematically overestimated in small samples, leading to poor generalizability and replicability of findings in all areas of research. Due to the large number of variables, this is particularly pr…
Development and validation of a computer program for measuring emotional awareness in German—The geLEAS (German electronic Levels of Emotional Awareness Scale) Open
Introduction Emotional awareness is the ability to identify, interpret, and verbalize the emotional responses of oneself and those of others. The Levels of Emotional Awareness Scale (LEAS) is an objective performance inventory that accurat…
View article: Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants
Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants Open
Background: Obesity is highly prevalent and disabling, especially in individuals with severe mental illness including bipolar disorders (BD). The brain is a target organ for both obesity and BD. Yet, we do not understand how cortical brain…
Morphometry variations of orbitofrontal regions for increased BMI and appetite in major depression Open
However, it is unclear if conceptually related atypical symptoms of changes in appetite are associated with similar neural alterations and if BMI and increasedappetite are also associated with white matter alterations. We employed a multi …
Understanding the neurobiological basis of anhedonia in major depressive disorder — evidence for reduced neural activation during reward and loss processing Open
Background: Anhedonia is a key symptom of major depressive disorder (MDD). Anhedonia is associated with aberrant reward processing, but whether it might interfere similarly with the neural processing of aversive stimuli, such as monetary l…
View article: Resting-state functional connectivity patterns associated with childhood maltreatment in a large bicentric cohort of adults with and without major depression
Resting-state functional connectivity patterns associated with childhood maltreatment in a large bicentric cohort of adults with and without major depression Open
Background Childhood maltreatment (CM) represents a potent risk factor for major depressive disorder (MDD), including poorer treatment response. Altered resting-state connectivity in the fronto-limbic system has been reported in maltreated…
View article: Changes in brain function during negative emotion processing in the long-term course of depression
Changes in brain function during negative emotion processing in the long-term course of depression Open
Background Relapses in major depression are frequent and are associated with a high burden of disease. Although short-term studies suggest a normalisation of depression-associated brain functional alterations directly after treatment, long…
View article: Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness—ENIGMA study in 2436 individuals
Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness—ENIGMA study in 2436 individuals Open
Aims Rates of obesity have reached epidemic proportions, especially among people with psychiatric disorders. While the effects of obesity on the brain are of major interest in medicine, they remain markedly under‐researched in psychiatry. …
Symptom Monitoring based on Digital Data Collection During Inpatient Treatment of Schizophrenia Spectrum Disorders – a Feasibility Study Open
Background Digital acquisition of risk factors and symptoms based on patients’ self-reports represents a promising, cost-efficient and increasingly prevalent approach for standardized data collection in psychiatric clinical routine. While …
A Network Control Theory Approach to Longitudinal Symptom Dynamics in\n Major Depressive Disorder Open
Background: The evolution of symptoms over time is at the heart of\nunderstanding and treating mental disorders. However, a principled,\nquantitative framework explaining symptom dynamics remains elusive. Here, we\npropose a Network Contro…
A Network Control Theory Approach to Longitudinal Symptom Dynamics in Major Depressive Disorder Open
Background: The evolution of symptoms over time is at the heart of understanding and treating mental disorders. However, a principled, quantitative framework explaining symptom dynamics remains elusive. Here, we propose a Network Control T…
View article: Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals Open
Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain su…
Evidence for a specific regional association between lateral orbitofrontal cortex morphometry and increased appetite in major depression Open
Increased appetite and body weight are core features of atypical depression. While previous research has consistently highlighted the presence of distinct immunometabolic profiles in atypical depression, little is still known about the neu…
Repeated Digitized Assessment of Risk and Symptom Profiles During Inpatient Treatment of Affective Disorder: Observational Study Open
Background Predictive models have revealed promising results for the individual prognosis of treatment response and relapse risk as well as for differential diagnosis in affective disorders. Yet, in order to translate personalized predicti…
Continuous digital collection of patient-reported outcomes during inpatient treatment for affective disorders – implementation and feasibility Open
Multivariate predictive models have revealed promising results for the individual prediction of treatment response, relapse risk as well as for the differential diagnosis in affective disorders. Yet, in order to translate personalized pred…