Explanipedia

Impaired Volume Regulation and Electrophysiology of Astrocytes In Situ in a Mouse Model for Megalencephalic Leukoencephalopathy With Subcortical Cysts Open

Sven Kerst, Nina Meesters, Tim S. Heistek, Marjo S. van der Knaap, Huibert D. Mansvelder , et al. · 2025

Electrical signaling, driven by ion fluxes between intra‐ and extracellular compartments, is central to brain functioning. Astrocytes provide crucial support by maintaining the homeostasis of water and ions in the brain. This is disrupted …

Astrocyte-Synapse Structural Plasticity in Neurodegenerative and Neuropsychiatric Diseases Open

Aina Badia‐Soteras, Aline Mak, Thomas M. Blok, Cristina Boers-Escuder, Michel C. van den Oever , et al. · 2025

Synaptic dysfunction is a common feature across a broad spectrum of brain diseases, spanning from psychopathologies such as posttraumatic stress disorder and substance use disorders to neurodegenerative diseases such as Alzheimer's disease…

Altered mechanical properties of astrocytes lacking MLC1; implications for the leukodystrophy MLC Open

Quinty Bisseling, Emma M. J. Passchier, Nelda Antonovaité, Serena Camerini, Maria Stefania Brignone , et al. · 2025

Loss of function of the astrocyte protein MLC1 causes Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC), a leukodystrophy characterized by white matter edema and slow neurological deterioration. MLC1 dysfunction leads to swe…

Inhibitory maturation and ocular dominance plasticity in mouse visual cortex require astrocyte CB1 receptors Open

Rogier Min, Yi Qin, Sven Kerst, M. Hadi Saiepour, Mariska van Lier , et al. · 2024

Endocannabinoids, signaling through the cannabinoid CB1 receptor (CB1R), regulate several forms of neuronal plasticity. CB1Rs in the developing primary visual cortex (V1) play a key role in the maturation of inhibitory circuits. Although C…

Megalencephalic leukoencephalopathy with subcortical cysts: a variant update and review of the literature Open

Emma M. J. Passchier, Quinty Bisseling, Guy Helman, Rosalina M.L. van Spaendonk, Cas Simons , et al. · 2024

The leukodystrophy megalencephalic leukoencephalopathy with subcortical cysts (MLC) is characterized by infantile-onset macrocephaly and chronic edema of the brain white matter. With delayed onset, patients typically experience motor probl…

Astrocyte CB1 receptors are required for inhibitory maturation and ocular dominance plasticity in the mouse visual cortex Open

Rogier Min, Yi Qin, Sven Kerst, M. Hadi Saiepour, Mariska van Lier , et al. · 2023

Summary and Introduction Neuronal circuits are shaped by experience. This happens much more readily in the young compared to the adult brain. The unique learning capacity of the young brain is regulated through postnatal critical periods, …

Aquaporin-4 and GPRC5B: old and new players in controlling brain oedema Open

Emma M. J. Passchier, Sven Kerst, Eelke Brouwers, Eline M. Hamilton, Quinty Bisseling , et al. · 2023

Brain oedema is a life-threatening complication of various neurological conditions. Understanding molecular mechanisms of brain volume regulation is critical for therapy development. Unique insight comes from monogenic diseases characteriz…

A novel role for <span>MLC1</span> in regulating astrocyte–synapse interactions Open

Mandy S. J. Kater, Katharina F. Baumgart, Aina Badia‐Soteras, Tim S. Heistek, Karen E. Carney , et al. · 2023

Loss of function of the astrocyte membrane protein MLC1 is the primary genetic cause of the rare white matter disease Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC), which is characterized by disrupted brain ion and water…

Editorial: The neuron-glia crosstalk and beyond Open

Jinte Middeldorp, Rogier Min, Joseph Benetatos, Liviu‐Gabriel Bodea · 2023

EDITORIAL article Front. Cell. Neurosci., 02 March 2023Sec. Non-Neuronal Cells Volume 17 - 2023 | https://doi.org/10.3389/fncel.2023.1159597

Retraction of Astrocyte Leaflets From the Synapse Enhances Fear Memory Open

Aina Badia‐Soteras, Tim S. Heistek, Mandy S. J. Kater, Aline Mak, Adrian Negrean , et al. · 2022

Presynaptic NMDA Receptors Influence Ca2+ Dynamics by Interacting with Voltage-Dependent Calcium Channels during the Induction of Long-Term Depression Open

Florian Neubauer, Rogier Min, Thomas Nevian · 2022

Spike-timing-dependent long-term depression (t-LTD) of glutamatergic layer (L)4-L2/3 synapses in developing neocortex requires activation of astrocytes by endocannabinoids (eCBs), which release glutamate onto presynaptic NMDA receptors (pr…

Proximity of astrocyte leaflets to the synapse determines memory strength Open

Aina Badia‐Soteras, Tim S. Heistek, Mandy S. J. Kater, Adrian Negrean, Huibert D. Mansvelder , et al. · 2022

Summary Astrocyte distal processes, known as leaflets or perisynaptic astrocyte processes (PAPs), fine-tune synaptic activity by clearing neurotransmitters and limiting extrasynaptic glutamate diffusion. While learning and memory depends o…

Bi-directional regulation of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatum Open

Sybren F. de Kloet, Bastiaan Bruinsma, Huub Terra, Tim S. Heistek, Emma M. J. Passchier , et al. · 2021

The medial prefrontal cortex (mPFC) steers goal-directed actions and withholds inappropriate behavior. Dorsal and ventral mPFC (dmPFC/vmPFC) circuits have distinct roles in cognitive control, but underlying mechanisms are poorly understood…

Bi-directional command of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatum Open

Sybren F. de Kloet, Bastiaan Bruinsma, Huub Terra, Tim S. Heistek, Emma M. J. Passchier , et al. · 2020

The medial prefrontal cortex (mPFC) steers goal-directed actions and withholds inappropriate behavior. Dorsal and ventral mPFC (dmPFC/vmPFC) circuits have distinct roles in cognitive control, but underlying mechanisms are poorly understood…

Genetic defects disrupting glial ion and water homeostasis in the brain Open

Rogier Min, Marjo S. van der Knaap · 2018

Electrical activity of neurons in the brain, caused by the movement of ions between intracellular and extracellular compartments, is the basis of all our thoughts and actions. Maintaining the correct ionic concentration gradients is theref…

Seizures and disturbed brain potassium dynamics in the leukodystrophy megalencephalic leukoencephalopathy with subcortical cysts Open

Mohit Dubey, Eelke Brouwers, Eline M. Hamilton, Oliver Stiedl, Marianna Bugiani , et al. · 2018

Objective Loss of function of the astrocyte‐specific protein MLC1 leads to the childhood‐onset leukodystrophy “megalencephalic leukoencephalopathy with subcortical cysts” (MLC). Studies on isolated cells show a role for MLC1 in astrocyte v…

Thalamic inhibition regulates critical-period plasticity in visual cortex and thalamus Open

Jean-Pierre Sommeijer, Mehran Ahmadlou, M. Hadi Saiepour, Koen Seignette, Rogier Min , et al. · 2017

Megalencephalic leukoencephalopathy with cysts: the<i>Glialcam</i>‐null mouse model Open

Marianna Bugiani, Mohit Dubey, Marjolein Breur, Nienke L. Postma, Marien P. Dekker , et al. · 2017

Objective Megalencephalic leukoencephalopathy with cysts ( MLC ) is a genetic infantile‐onset disease characterized by macrocephaly and white matter edema due to loss of MLC 1 function. Recessive mutations in either MLC 1 or GLIALCAM cause…

β-Catenin in the Adult Visual Cortex Regulates NMDA-Receptor Function and Visual Responses Open

M. Hadi Saiepour, Rogier Min, Willem Kamphuis, J. Alexander Heimel, Christiaan N. Levelt · 2017

The formation, plasticity and maintenance of synaptic connections is regulated by molecular and electrical signals. β-Catenin is an important protein in these events and regulates cadherin-mediated cell adhesion and the recruitment of pre-…

Mechanisms underlying the induction and expression of spike-timing dependent depression at L4-L2/3 synapses in barrel cortex Open

Rogier Min, Thomas Nevian · 2015

Rogier Min YOU? Author Swipe