Rohan L. Fernando
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View article: 60 Whole genome prediction of the onset of puberty in a pig growth model based on body weight and feed intake data from boar stations using a Bayesian hierarchical model.
60 Whole genome prediction of the onset of puberty in a pig growth model based on body weight and feed intake data from boar stations using a Bayesian hierarchical model. Open
Pig breeding companies collect data on body weight and feed intake each time boars visit individual automatic feeding stations at boar testing farms. Proper modeling of feed intake and body weight gain is essential for achieving significan…
View article: A Family Cluster of Imported Human <i>Brucella melitensis</i> Infection with Probable Breast Milk Transmission: A Case Series.
A Family Cluster of Imported Human <i>Brucella melitensis</i> Infection with Probable Breast Milk Transmission: A Case Series. Open
Human brucellosis is a zoonotic, bacterial infection caused by the intracellular, Gram-negative Brucella spp., which is common globally but rare in the United Kingdom, with approximately 20 imported cases per annum following travel to coun…
View article: IMPLEMENTATION OF GOTO TRADEMARK PROTECTION BASED ON THE PRINCIPLE OF “SUBSTANTIAL SIMILARITY”
IMPLEMENTATION OF GOTO TRADEMARK PROTECTION BASED ON THE PRINCIPLE OF “SUBSTANTIAL SIMILARITY” Open
Trademark protection is a crucial aspect of intellectual property law, aimed at safeguarding trademark owners and preventing consumer confusion. This study analyzes the implementation of the "substantial similarity" principle in a trademar…
View article: A Network Analysis Approach to Detect and Differentiate Usher Syndrome Types Using miRNA Expression Profiles: A Pilot Study
A Network Analysis Approach to Detect and Differentiate Usher Syndrome Types Using miRNA Expression Profiles: A Pilot Study Open
Background: Usher syndrome (USH) is a rare genetic disorder that affects both hearing and vision. It presents in three clinical types—USH1, USH2, and USH3—with varying onset, severity, and disease progression. Existing diagnostics primaril…
View article: Use of the linear regression method to evaluate population accuracy of predictions from non-linear models
Use of the linear regression method to evaluate population accuracy of predictions from non-linear models Open
Background To address the limitations of commonly used cross-validation methods, the linear regression method (LR) was proposed to estimate population accuracy of predictions based on the implicit assumption that the fitted model is correc…
View article: P686: Characterization of Usher syndrome cell line genotypes and investigation of novel microRNA biomarkers using microRNA microarray and droplet digital PCR
P686: Characterization of Usher syndrome cell line genotypes and investigation of novel microRNA biomarkers using microRNA microarray and droplet digital PCR Open
Usher syndrome (USH) is an inherited disorder characterized by sensorineural hearing loss (SNHL), retinitis pigmentosa (RP)-related vision loss, and vestibular dysfunction, presenting as three distinct clinical types. Usher syndrome affect…
View article: Validation of the linear regression method to evaluate population accuracy and bias of predictions for non-linear models
Validation of the linear regression method to evaluate population accuracy and bias of predictions for non-linear models Open
Background The linear regression method (LR) was proposed to estimate population bias and accuracy of predictions, while addressing the limitations of commonly used cross-validation methods. The validity and behavior of the LR method have …
View article: Characteristics Associated With Health Care Worker Knowledge and Confidence in Elastomeric Half-Mask Respirator Use
Characteristics Associated With Health Care Worker Knowledge and Confidence in Elastomeric Half-Mask Respirator Use Open
Objective This study evaluated health care workers' (HCWs') knowledge and confidence in using elastomeric half-mask respirator (EHMR) attributes known to influence usage. Methods Health care workers were surveyed regarding their EHMR donni…
View article: XSim version 2: simulation of modern breeding programs
XSim version 2: simulation of modern breeding programs Open
Simulation can be an efficient approach to design, evaluate, and optimize breeding programs. In the era of modern agriculture, breeding programs can benefit from a simulator that integrates various sources of big data and accommodates stat…
View article: Additional file 1 of A method to obtain exact single-step GBLUP for non-genotyped descendants when the genomic relationship matrix of ancestors is not available
Additional file 1 of A method to obtain exact single-step GBLUP for non-genotyped descendants when the genomic relationship matrix of ancestors is not available Open
Additional file 1. Numerical example of Bayesian updating of a P-BLUP evaluation. This example shows that Bayesian updating of an external evaluation with the current data yields identical results to those from a joint analysis of the data…
View article: Genome-wide association study of disease resilience traits from a natural polymicrobial disease challenge model in pigs identifies the importance of the major histocompatibility complex region
Genome-wide association study of disease resilience traits from a natural polymicrobial disease challenge model in pigs identifies the importance of the major histocompatibility complex region Open
Infectious diseases cause tremendous financial losses in the pork industry, emphasizing the importance of disease resilience, which is the ability of an animal to maintain performance under disease. Previously, a natural polymicrobial dise…
View article: Further host-genomic characterization of total antibody response to PRRSV vaccination and its relationship with reproductive performance in commercial sows: genome-wide haplotype and zygosity analyses
Further host-genomic characterization of total antibody response to PRRSV vaccination and its relationship with reproductive performance in commercial sows: genome-wide haplotype and zygosity analyses Open
Background The possibility of using antibody response (S/P ratio) to PRRSV vaccination measured in crossbred commercial gilts as a genetic indicator for reproductive performance in vaccinated crossbred sows has motivated further studies of…
View article: 14 Genome-wide Association Studies of Disease Resilience Traits from a Natural Polymicrobial Disease Challenge in Pigs
14 Genome-wide Association Studies of Disease Resilience Traits from a Natural Polymicrobial Disease Challenge in Pigs Open
Infectious diseases cause tremendous financial loss in the pork industry, emphasizing the importance of disease resilience, which is the ability of an animal to maintain performance under disease. The objective of this study was to identif…
View article: Interpretable artificial neural networks incorporating Bayesian alphabet models for genome-wide prediction and association studies
Interpretable artificial neural networks incorporating Bayesian alphabet models for genome-wide prediction and association studies Open
In conventional linear models for whole-genome prediction and genome-wide association studies (GWAS), it is usually assumed that the relationship between genotypes and phenotypes is linear. Bayesian neural networks have been used to accoun…
View article: 40 Novel Genomic Regions Associated with Igg Antibody Response to PRRSV Vaccination Revealed by Haplotype-based GWAS
40 Novel Genomic Regions Associated with Igg Antibody Response to PRRSV Vaccination Revealed by Haplotype-based GWAS Open
Previous studies on genomics of antibody response, measured as sample-to-positive (S/P) ratio, to Porcine Reproductive and Respiratory Syndrome virus (PRRSV) have reported a major quantitative trait locus (QTL) on the major histocompatibil…
View article: 129 Genomic Relationship Between PRRSV Wild-type Infection and PRRSV Vaccination for Antibody Response and Reproductive Performance
129 Genomic Relationship Between PRRSV Wild-type Infection and PRRSV Vaccination for Antibody Response and Reproductive Performance Open
Immunoglobulin G antibody response, measured as sample-to-positive (S/P) ratio, to Porcine Reproductive and Respiratory Syndrome virus (PRRSV) has been proposed as an indicator trait for improved reproductive performance in PRRSV-infected …
View article: Interpretable Artificial Neural Networks incorporating Bayesian Alphabet Models for Genome-wide Prediction and Association Studies
Interpretable Artificial Neural Networks incorporating Bayesian Alphabet Models for Genome-wide Prediction and Association Studies Open
In conventional linear models for whole-genome prediction and genome-wide association studies (GWAS), it is usually assumed that the relationship between genotypes and phenotypes is linear. Bayesian neural networks have been used to accoun…
View article: Genomics of response to porcine reproductive and respiratory syndrome virus in purebred and crossbred sows: antibody response and performance following natural infection vs. vaccination
Genomics of response to porcine reproductive and respiratory syndrome virus in purebred and crossbred sows: antibody response and performance following natural infection vs. vaccination Open
Antibody response, measured as sample-to-positive (S/P) ratio, to porcine reproductive and respiratory syndrome virus (PRRSV) following a PRRSV-outbreak (S/POutbreak) in a purebred nucleus and following a PRRSV-vaccination (S/PVx) in comme…
View article: Cross‐validation of best linear unbiased predictions of breeding values using an efficient leave‐one‐out strategy
Cross‐validation of best linear unbiased predictions of breeding values using an efficient leave‐one‐out strategy Open
Empirical estimates of the accuracy of estimates of breeding values (EBV) can be obtained by cross‐validation. Leave‐one‐out cross‐validation (LOOCV) is an extreme case of k‐fold cross‐validation. Efficient strategies for LOOCV of predicti…
View article: Additional file 1 of Further host-genomic characterization of total antibody response to PRRSV vaccination and its relationship with reproductive performance in commercial sows: genome-wide haplotype and zygosity analyses
Additional file 1 of Further host-genomic characterization of total antibody response to PRRSV vaccination and its relationship with reproductive performance in commercial sows: genome-wide haplotype and zygosity analyses Open
Additional file 1: Table S1. ROH and ROHet identified in the study. Spreadsheets 1 and 2 contain results for ROH and ROHet, respectively. The columns represent: (1) ROH/ROHet numbered according to the number of SNPs within each ROH/ROHet; …
View article: Additional file 6 of Further host-genomic characterization of total antibody response to PRRSV vaccination and its relationship with reproductive performance in commercial sows: genome-wide haplotype and zygosity analyses
Additional file 6 of Further host-genomic characterization of total antibody response to PRRSV vaccination and its relationship with reproductive performance in commercial sows: genome-wide haplotype and zygosity analyses Open
Additional file 6: Table S5. Effect of S/P ratio haplotypes on reproductive performance. The columns represent: (1) reproductive traits; (2) haplotype numbered according to their location along the genome; (3) haplotype; (4) expected mean …