Rohan Pradhan
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View article: New chimeric HDAC inhibitors for the treatment of colorectal cancer
New chimeric HDAC inhibitors for the treatment of colorectal cancer Open
Colorectal cancer is the third most common cause of cancer‐associated deaths due to a high recurrence rate and an increasing occurrence of resistance to established therapies. This highlights the importance of developing new chemotherapeut…
View article: Improved Anticancer Activities of a New Pentafluorothio-Substituted Vorinostat-Type Histone Deacetylase Inhibitor
Improved Anticancer Activities of a New Pentafluorothio-Substituted Vorinostat-Type Histone Deacetylase Inhibitor Open
The development of new anticancer drugs is necessary in order deal with the disease and with the drawbacks of currently applied drugs. Epigenetic dysregulations are a central hallmark of cancerogenesis and histone deacetylases (HDACs) emer…
View article: The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells
The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells Open
The natural hirudin and JAK2/STATs signal inhibitor AG490 could block the effects of thrombin. Natural hirudin could attenuate HMVECs apoptosis via antagonizing thrombin and it is suggested that this effect may occur by blocking the JAK2/S…
View article: The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells
The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells Open
Purpose: To investigate whether hirudin exerts its antithrombin action to decrease the ratio of Human Microvascular Endothelial Cells (HMVECs) apoptosis. Methods: Human microvascular endothelial cells (HMVECs) cultured in the third and fif…
View article: [Effects of combined natural hirudin and hyperbaric oxygen therapy on survival of transplanted random-pattern skin flap in rats].
[Effects of combined natural hirudin and hyperbaric oxygen therapy on survival of transplanted random-pattern skin flap in rats]. Open
Hyperbaric oxygen and natural hirudin therapy after random-pattern skin flap transplantation can improve the survival of flaps. Moreover, combined therapy is seen to exhibit significant synergistic effect. This effect maybe related to prom…