Abstract BACKGROUND: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder resembling Amavata in Ayurveda , marked by joint inflammation and systemic symptoms. While conventional treatments offer symptomatic relief, long-term adherence, adverse effects, and limited accessibility remain concerns, warranting patient-centered alternatives. Ayurveda outlines multi-modality therapies for Amavata , though real-world evidence on their safety, efficacy, and acceptability is limited. OBJECTIVE: To assess …

Aim: To review the intrinsic tenants available for safe drug usage in Ayurveda and to contextualize the statistical signal detection techniques of current times in terms of Ayurvedic pharmacovigilance program. Materials and methods: Streamlining the information to develop a database that differentiates between known adverse drug reactions (ADRs) from hitherto unknown drug reactions per the standard definition of ADR. To introduce amicable statistical methods viz., Chi-square test, odds ratio (OR), and logistic reg…