Rajan P. Nair
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View article: GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets Open
Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to psoriasis is not …
View article: GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets Open
Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to psoriasis is not …
View article: Retrospective pharmacogenetic study of psoriasis highlights the role of <i>KLK7</i> in tumour necrosis factor signalling
Retrospective pharmacogenetic study of psoriasis highlights the role of <i>KLK7</i> in tumour necrosis factor signalling Open
Background Multiple treatment options are available for the management of psoriasis, but clinical response varies among individual patients and no biomarkers are available to facilitate treatment selection for improved patient outcomes. Ob…
View article: Shared Genetic Risk Factors for <scp>Multiple Sclerosis</scp>/Psoriasis Suggest Involvement of <scp>Interleukin‐17</scp> and <scp>Janus Kinase–Signal Transducers and Activators of Transcription</scp> Signaling
Shared Genetic Risk Factors for <span>Multiple Sclerosis</span>/Psoriasis Suggest Involvement of <span>Interleukin‐17</span> and <span>Janus Kinase–Signal Transducers and Activators of Transcription</span> Signaling Open
Objective Psoriasis and multiple sclerosis (MS) are complex immune diseases that are mediated by T cells and share multiple comorbidities. Previous studies have suggested psoriatic patients are at higher risk of MS; however, causal relatio…
View article: Data from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species
Data from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species Open
The RAS/BRAF/MEK/ERK mitogen-activated protein kinase (MAPK) pathway is emerging as a key modulator of melanoma initiation and progression. However, a variety of clinical studies indicate that inhibiting the MAPK pathway is insufficient pe…
View article: Supplementary Figures 1-5 from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species
Supplementary Figures 1-5 from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species Open
Supplementary Figures 1-5 from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species
View article: Data from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species
Data from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species Open
The RAS/BRAF/MEK/ERK mitogen-activated protein kinase (MAPK) pathway is emerging as a key modulator of melanoma initiation and progression. However, a variety of clinical studies indicate that inhibiting the MAPK pathway is insufficient pe…
View article: Supplementary Materials, Methods and Figure Legends 1-5 from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species
Supplementary Materials, Methods and Figure Legends 1-5 from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species Open
Supplementary Materials, Methods and Figure Legends 1-5 from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species
View article: Supplementary Materials, Methods and Figure Legends 1-5 from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species
Supplementary Materials, Methods and Figure Legends 1-5 from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species Open
Supplementary Materials, Methods and Figure Legends 1-5 from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species
View article: Supplementary Figures 1-5 from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species
Supplementary Figures 1-5 from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species Open
Supplementary Figures 1-5 from A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species
View article: A Cross-Trait Genetic Correlation Study Identified Eight Diseases and Traits Associated with Psoriasis
A Cross-Trait Genetic Correlation Study Identified Eight Diseases and Traits Associated with Psoriasis Open
View article: Exome-Guided Proteomic Analysis Identifies Early Biomarkers for the Progression from Psoriasis to Psoriatic Arthritis
Exome-Guided Proteomic Analysis Identifies Early Biomarkers for the Progression from Psoriasis to Psoriatic Arthritis Open
View article: Bregman Divergence-Based Data Integration with Application to Polygenic Risk Score (PRS) Heterogeneity Adjustment
Bregman Divergence-Based Data Integration with Application to Polygenic Risk Score (PRS) Heterogeneity Adjustment Open
Polygenic risk scores (PRS) have recently received much attention for genetics risk prediction. While successful for the Caucasian population, the PRS based on the minority population suffer from small sample sizes, high dimensionality and…
View article: Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine mapping in the MHC and genome wide
Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine mapping in the MHC and genome wide Open
Because transethnic analysis may facilitate prioritization of causal genetic variants, we performed a genomewide association study (GWAS) of psoriasis in South Asians (SAS), consisting of 2,590 cases and 1,720 controls. Comparison with our…
View article: Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis
Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis Open
Killer cell immunoglobulin-like receptors (KIR) regulate immune responses in NK and CD8+ T cells via interaction with HLA ligands. KIR genes, including KIR2DS1, KIR3DL1, and KIR3DS1 have previously been implicated in psoriasis susceptibili…
View article: 161 Pharmacogenetics study of different psoriasis treatments
161 Pharmacogenetics study of different psoriasis treatments Open
View article: Causal Relationship and Shared Genetic Loci between Psoriasis and Type 2 Diabetes through Trans-Disease Meta-Analysis
Causal Relationship and Shared Genetic Loci between Psoriasis and Type 2 Diabetes through Trans-Disease Meta-Analysis Open
View article: Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study
Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study Open
View article: Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study Open
C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal.
View article: Quantifying Differences in Heritability among Psoriatic Arthritis (PsA), Cutaneous Psoriasis (PsC) and Psoriasis vulgaris (PsV)
Quantifying Differences in Heritability among Psoriatic Arthritis (PsA), Cutaneous Psoriasis (PsC) and Psoriasis vulgaris (PsV) Open
View article: Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity Open
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 control…
View article: Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways
Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways Open
Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases and 1,436 controls of European ancestry. We followed up 2…
View article: AB0020B QUANTIFYING DIFFERENCES IN HERITABILITY AMONG PSORIATIC ARTHRITIS (PSA), CUTANEOUS PSORIASIS (PSC) AND PSORIASIS VULGARIS (PSV)
AB0020B QUANTIFYING DIFFERENCES IN HERITABILITY AMONG PSORIATIC ARTHRITIS (PSA), CUTANEOUS PSORIASIS (PSC) AND PSORIASIS VULGARIS (PSV) Open
View article: 398 Neutrophil extracellular trap-dependent Th17 polarization of memory T-cells requires monocyte-T-cell contact and stimulates cytokine gene expression in an Act1D10N-dependent manner
398 Neutrophil extracellular trap-dependent Th17 polarization of memory T-cells requires monocyte-T-cell contact and stimulates cytokine gene expression in an Act1D10N-dependent manner Open
View article: Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC
Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC Open
We recently conducted a large association analysis to compare the genetic profiles between patients with psoriatic arthritis (PsA) and cutaneous-only psoriasis (PsC). Despite including over 7,000 genotyped patients, only the MHC achieved g…
View article: Neutrophil Extracellular Traps Induce Human Th17 Cells: Effect of Psoriasis-Associated TRAF3IP2 Genotype
Neutrophil Extracellular Traps Induce Human Th17 Cells: Effect of Psoriasis-Associated TRAF3IP2 Genotype Open
View article: A Transethnic Mendelian Randomization Study Identifies Causality of Obesity on Risk of Psoriasis
A Transethnic Mendelian Randomization Study Identifies Causality of Obesity on Risk of Psoriasis Open
View article: Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients Open
View article: The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells
The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells Open
View article: 800 The effect of neutrophils on Th17 expansion is monocyte-dependent
800 The effect of neutrophils on Th17 expansion is monocyte-dependent Open