Ratna B. Ray
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View article: Targeted Deletion of the Cytopathogenic Toxin A Gene in <i>Sneathia vaginalis</i>
Targeted Deletion of the Cytopathogenic Toxin A Gene in <i>Sneathia vaginalis</i> Open
Sneathia vaginalis is a common component of the vaginal microbiome and is emerging as a marker for preterm birth. It produces the cytopathogenic toxin A (CptA), which is capable of lysing human red blood cells and permeabilizing epithelial…
View article: Metabotissugenic citrate biomaterials orchestrate bone regeneration via citrate-mediated signaling pathways
Metabotissugenic citrate biomaterials orchestrate bone regeneration via citrate-mediated signaling pathways Open
Bone regeneration requires coordinated anabolic and catabolic signaling, yet the interplay between mammalian target of rapamycin complex 1 (mTORC1) and adenosine monophosphate–activated protein kinase (AMPK) pathways remains unclear. This …
View article: Targeting Triple-Negative Breast Cancer with Momordicine-I for Therapeutic Gain in Preclinical Models
Targeting Triple-Negative Breast Cancer with Momordicine-I for Therapeutic Gain in Preclinical Models Open
Background: TNBC patients respond poorly to chemotherapy, leading to high mortality rates and a worsening prognosis. Here, we investigated the effect of M-I on TNBC tumor growth suppression and its potential mechanisms. Methods: Signaling …
View article: Long non‐coding <scp>RNAs</scp> as therapeutic targets in head and neck squamous cell carcinoma and clinical application
Long non‐coding <span>RNAs</span> as therapeutic targets in head and neck squamous cell carcinoma and clinical application Open
Head and neck squamous cell carcinoma (HNSCC) is a major global health burden, often associated with poor prognosis and limited therapeutic options. Long non‐coding RNAs (lncRNAs), a diverse group of non‐coding RNA molecules > 200 nucleoti…
View article: Momordicine-I suppresses head and neck cancer growth by modulating key metabolic pathways
Momordicine-I suppresses head and neck cancer growth by modulating key metabolic pathways Open
One of the hallmarks of cancer is metabolic reprogramming which controls cellular homeostasis and therapy resistance. Here, we investigated the effect of momordicine-I (M-I), a key bioactive compound from Momordica charantia (bitter melon)…
View article: Silmitasertib in Combination With Cabozantinib Impairs Liver Cancer Cell Cycle Progression, Induces Apoptosis, and Delays Tumor Growth in a Preclinical Model
Silmitasertib in Combination With Cabozantinib Impairs Liver Cancer Cell Cycle Progression, Induces Apoptosis, and Delays Tumor Growth in a Preclinical Model Open
The rising incidence of hepatocellular carcinoma (HCC) is a global problem. Several approved treatments, including immune therapy and multi‐tyrosine kinase inhibitors, are used for treatment, although the results are not optimum. There is …
View article: Supplementary Figure 3 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 3 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 3: A, Violin plots showing the number of genes (top panel) and unique molecular identifier (UMI) (bottom panel) of control and M-I-treated CD45+ cells. B, Number of the genes in each cluster is shown.
View article: Supplementary Figure 2 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 2 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 2: Image showing the gating strategy of flow cytometry and cell sorting.
View article: Data from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Data from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Head and neck cancer (HNC) is prevalent worldwide, and treatment options are limited. Momordicine-I (M-I), a natural component from bitter melon, shows antitumor activity against these cancers, but its mechanism of action, especially in th…
View article: Supplementary Figure 2 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 2 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 2: Image showing the gating strategy of flow cytometry and cell sorting.
View article: Supplementary Figure 1 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 1 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 1: MOC2 cells treated with bitter melon extract (BME) or momordicine -I (M-I). Cell number was enumerated by the Trypan blue dye exclusion method after 48 hours of treatment. The results shown are the average of three …
View article: Supplementary Figure 4 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 4 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 4: A, Volcano plot illustrates the expression of genes in cDC2 populations in the treated group as compared to the control tumors. The x-axis represents log2 -fold change, and the y-axis denotes (−log10) p-value showin…
View article: Supplementary Figure 4 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 4 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 4: A, Volcano plot illustrates the expression of genes in cDC2 populations in the treated group as compared to the control tumors. The x-axis represents log2 -fold change, and the y-axis denotes (−log10) p-value showin…
View article: Data from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Data from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Head and neck cancer (HNC) is prevalent worldwide, and treatment options are limited. Momordicine-I (M-I), a natural component from bitter melon, shows antitumor activity against these cancers, but its mechanism of action, especially in th…
View article: Supplementary Figure 3 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 3 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 3: A, Violin plots showing the number of genes (top panel) and unique molecular identifier (UMI) (bottom panel) of control and M-I-treated CD45+ cells. B, Number of the genes in each cluster is shown.
View article: Supplementary Figure 1 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 1 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 1: MOC2 cells treated with bitter melon extract (BME) or momordicine -I (M-I). Cell number was enumerated by the Trypan blue dye exclusion method after 48 hours of treatment. The results shown are the average of three …
View article: Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Head and neck cancer (HNC) is prevalent worldwide, and treatment options are limited. Momordicine-I (M-I), a natural component from bitter melon, shows antitumor activity against these cancers, but its mechanism of action, especially in th…
View article: Emerging Potential of Momordica’s Bioactive Phytochemicals in Cancer Prevention and Therapy
Emerging Potential of Momordica’s Bioactive Phytochemicals in Cancer Prevention and Therapy Open
Worldwide, cancer incidence and mortality are rising quickly. Cancer remains the biggest cause of death despite advances in therapy. Plants produce bioactive phytochemicals, and as a result, the bioactive elements have long been the focus …
View article: Molecular Changes in Relation to Alcohol Consumption and Hepatocellular Carcinoma
Molecular Changes in Relation to Alcohol Consumption and Hepatocellular Carcinoma Open
Alcohol is the one of the major causes of liver diseases and promotes liver cirrhosis and hepatocellular carcinoma (HCC). In hepatocytes, alcohol is converted to acetaldehyde, which causes hepatic steatosis, cellular apoptosis, endoplasmic…
View article: Circulatory Exosomes from COVID-19 Patients Trigger NLRP3 Inflammasome in Endothelial Cells
Circulatory Exosomes from COVID-19 Patients Trigger NLRP3 Inflammasome in Endothelial Cells Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health problem. Although the vaccine controls infection, understanding the molecular mechanism of pathogenesis will help in developing future therapies.
View article: Circulatory exosomes from COVID-19 patients trigger NLRP3 inflammasome in endothelial cells
Circulatory exosomes from COVID-19 patients trigger NLRP3 inflammasome in endothelial cells Open
SARS-CoV-2 infection induces inflammatory response, cytokine storm, venous thromboembolism, coagulopathy, and multiple organ damage. Resting endothelial cells prevent coagulation, control blood flow and inhibit inflammation. However, it re…