Explanipedia

INCIDENCE AND PREDICTORS OF POST-TRANSPLANT MALIGNANCY IN LIVER TRANSPLANT RECIPIENTS: A SINGLE-CENTRE COHORT STUDY Open

Iria Francisco, Ángela Pedro, Abed A. Saqah, Hashaal Alkhurassi, Saad A. Aldosari , et al. · 2025

Introduction and Objectives: Cancer is a major long-term complication after liver transplantation (LT). We aimed to characterize its incidence and risk factors in LT recipients at a Canadian center. Materials and Methods: Retrospective coh…

Pentoxifylline use in alcohol-associated hepatitis with acute kidney injury does not improve survival: a global study Open

Francisco Idalsoaga, Luis Antonio Díaz, Winston Dunn, Heer H. Mehta, Vicente Caldentey , et al. · 2025

Background Severe alcohol-associated hepatitis (sAH) is a life-threatening condition with high mortality, where corticosteroid use is the only treatment that has shown short-term benefits. Pentoxifylline, an anti-tumour necrosis factor-alp…

Moderate alcohol-associated hepatitis: A real-world multicenter study Open

Francisco Idalsoaga, Luis Antonio Díaz, Winston Dunn, Heer H. Mehta, Karen E. Muñoz , et al. · 2025

Background: Severe alcohol-associated hepatitis (sAH) is a well-characterized disease with high short-term mortality. However, there is limited research on those with a “less severe condition” (moderate AH). This study aims to characterize…

Comparison Between Dynamic Models for Predicting Response to Corticosteroids in Alcohol‐Associated Hepatitis: A Global Cohort Study Open

Francisco Idalsoaga, Luis Antonio Díaz, Leonardo Guizzetti, Winston Dunn, Heer H. Mehta , et al. · 2025

Several dynamic models predict mortality and corticosteroid response in alcohol‐associated hepatitis (AH), yet no consensus exists on the most effective model. This study aimed to assess predictive models for corticosteroid response and sh…

Periodontal disease and cirrhosis: current concepts and future prospects Open

David Hudson, Gustavo Ayares, Zahra Taboun, Gurpreet Malhi, Francisco Idalsoaga , et al. · 2025

Periodontal diseases are prevalent among the general population and are associated with several systemic conditions, such as chronic kidney disease and type 2 diabetes mellitus. Chronic liver disease and cirrhosis have also been linked wit…

Comparative effectiveness of different corticosteroid regimens in severe alcohol-associated hepatitis Open

Alvi H. Islam, Luis Antonio Díaz, Francisco Idalsoaga, Leonardo Guizzetti, Rokhsana Mortuza , et al. · 2024

A297 EXAMINING THE IMPACT OF INFLAMMATORY BOWEL DISEASE IN PRIMARY SCLEROSING CHOLANGITIS PATIENTS POST LIVER TRANSPLANTATION Open

G Malhi, Luis A. Díaz, Gopika Punchhi, Rokhsana Mortuza, M K Khan , et al. · 2024

Background Primary sclerosing cholangitis (PSC) is an immune-mediated disease that is characterized by biliary inflammation and fibrosis. It is associated with inflammatory bowel disease (IBD) in 80% of cases. To date, the impact of IBD in…

A302 NON-INVASIVE BIOMARKERS PREDICTING THE PROGRESSION OF MASLD TO ADVANCED FIBROSIS: A PROSPECTIVE COHORT STUDY Open

Yun Song, Rokhsana Mortuza, Juan Pablo Arab, M K Khan · 2024

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) affects around 30% of the global population and is one of the most prevalent non-communicable diseases. Due to its high prevalence, it is becoming the most common …

Low-flow intussusception and metastable VEGFR2 signaling launch angiogenesis in ischemic muscle Open

John‐Michael Arpino, Hao Yin, Emma Prescott, Sabrina C. R. Staples, Zengxuan Nong , et al. · 2021

The vasculature in ischemic muscle is rebuilt by the splitting of primordial vessels, led by VEGFR2-metastable endothelial cells.

<span>SIRT</span>1 reduction causes renal and retinal injury in diabetes through endothelin 1 and transforming growth factor β1 Open

Rokhsana Mortuza, Biao Feng, Subrata Chakrabarti · 2015

In diabetes, hyperglycaemia causes up‐regulation of endothelin 1 ( ET ‐1) and transforming growth factor beta 1 ( TGF ‐β1). Previously we showed glucose reduces sirtuin1 ( SIRT 1), a class III histone deacetylase. Here, we investigated the…

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