Rola Ghasoub
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View article: Therapeutic positioning of asciminib in chronic myeloid leukemia patients previously treated with multiple tyrosine kinase inhibitors in Qatar
Therapeutic positioning of asciminib in chronic myeloid leukemia patients previously treated with multiple tyrosine kinase inhibitors in Qatar Open
View article: Tyrosine kinase inhibitors and secondary malignancies in chronic myeloid leukemia: A protocol for systematic review
Tyrosine kinase inhibitors and secondary malignancies in chronic myeloid leukemia: A protocol for systematic review Open
Background: Chronic myeloid leukemia (CML) is a hematologic malignancy characterized by the BCR-ABL1 fusion oncogene and effectively treated with tyrosine kinase inhibitors (TKIs). While TKIs have significantly improved survival, their lon…
View article: A deep dive into the surgical and pharmacological considerations of obesity in chronic myeloid leukemia: a narrative review
A deep dive into the surgical and pharmacological considerations of obesity in chronic myeloid leukemia: a narrative review Open
Background/Objectives The rising prevalence of obesity presents significant challenges in managing chronic myeloid leukemia (CML). Bariatric surgery alters the bioavailability of oral medications, necessitating tailored treatment strategie…
View article: Upfront fixed-duration treatment strategies for chronic lymphocytic leukemia in Arab populations: a position statement from the Gulf region
Upfront fixed-duration treatment strategies for chronic lymphocytic leukemia in Arab populations: a position statement from the Gulf region Open
The treatment landscape for chronic lymphocytic leukemia (CLL) has expanded dramatically over the last decade, with a wide range of effective treatments now available. Clinical management of CLL varies widely depending on patient profile, …
View article: A multicenter mixed-methods study on the effects of intermittent fasting in patients with immune thrombocytopenia receiving thrombopoietin receptor agonists
A multicenter mixed-methods study on the effects of intermittent fasting in patients with immune thrombocytopenia receiving thrombopoietin receptor agonists Open
Introduction In recent years, significant advances have been made in the treatment of immune thrombocytopenia (ITP) with the development of thrombopoietin receptor agonists (TPO-RAs). TPO-RAs are often used following the failure of prior t…
View article: Caught in the Crossfire: Unmasking the Silent Renal Threats of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
Caught in the Crossfire: Unmasking the Silent Renal Threats of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia Open
Background: Renal adverse drug reactions (ADRs) associated with tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML) are relatively rare, and there is currently no standardized protocol for their management.…
View article: Venetoclax in the treatment of secondary plasma cell leukemia with translocation t(11;14): a case report and literature review
Venetoclax in the treatment of secondary plasma cell leukemia with translocation t(11;14): a case report and literature review Open
Introduction Venetoclax is a BCL-2 inhibitor with proven efficacy in patients with multiple myeloma (MM) and translocation t(11;14). However, its role in plasma cell leukemia (PCL) remains unclear. Herein, we aimed to report a case of rela…
View article: Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes
Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes Open
Background Plasmacytoma of the skull base is a rare manifestation of plasma cell neoplasm with only a few cases documented in literature involving young adults. Plasmacytoma can be an isolated solitary lesion or a secondary manifestation o…
View article: Establishment of a clinical pharmacist-led multiple myeloma clinic with collaborative prescribing model at the national center for cancer care and research in Qatar
Establishment of a clinical pharmacist-led multiple myeloma clinic with collaborative prescribing model at the national center for cancer care and research in Qatar Open
The CP-led clinic provided a timely link to care optimization for ambulatory MM patients. This innovative CPA model implemented in the clinic could potentially be applied to different cancer settings to optimize safe and effective patient …
View article: The Safety of Novel Therapies in Chronic Lymphocytic Leukemia in the Era of Intermittent Fasting: A Pharmacology-Based Review
The Safety of Novel Therapies in Chronic Lymphocytic Leukemia in the Era of Intermittent Fasting: A Pharmacology-Based Review Open
Intermittent fasting (IF) has recently gained popularity due to its emerging benefits in reducing weight and improving metabolic health. Concurrently, novel agents (NAs) like venetoclax and Bruton tyrosine kinase inhibitors (BTKIs) have re…
View article: Disseminated tuberculosis after <scp>Polatuzumab‐Vedotin</scp> based chemoimmunotherapy in a patient with Burkitt's lymphoma
Disseminated tuberculosis after <span>Polatuzumab‐Vedotin</span> based chemoimmunotherapy in a patient with Burkitt's lymphoma Open
Key Clinical Message This report highlights the risk of latent tuberculosis (TB) reactivation after treatment with Polatuzumab Vedotin (PV), Rituximab, and Bendamustine (PBR protocol) despite appropriate chemoprophylaxis. A 48‐year‐old mal…
View article: Early predictors of intensive care unit admission among COVID-19 patients in Qatar
Early predictors of intensive care unit admission among COVID-19 patients in Qatar Open
Background COVID-19 is associated with significant morbidity and mortality. This study aimed to explore the early predictors of intensive care unit (ICU) admission among patients with COVID-19. Methods This was a case–control study of adul…
View article: Real world evidence of epidemiological trends, clinical presentation, and prognostic outcomes of multiple myeloma (2007-2021)
Real world evidence of epidemiological trends, clinical presentation, and prognostic outcomes of multiple myeloma (2007-2021) Open
Background Multiple myeloma (MM) is one of the most common hematological malignancies globally, and it is projected to increase in the coming years. It occurs more frequently in males and affects older individuals. Presenting symptoms can …
View article: Relapsed IgA Multiple Myeloma as Testicular Plasmacytoma after Quadrable Novel Therapy and Autologous Stem Cell Transplant: A Rare Case Report and Literature Review
Relapsed IgA Multiple Myeloma as Testicular Plasmacytoma after Quadrable Novel Therapy and Autologous Stem Cell Transplant: A Rare Case Report and Literature Review Open
Introduction: Multiple myeloma (MM) is a clonal neoplasm of plasma cells that may manifest as an extramedullary disease in rare cases. Case Report: In this case report, we present the rare occurrence of testicul…
View article: Tyrosine Kinase Inhibitors in pediatric chronic myeloid leukemia: a focused review of clinical trials
Tyrosine Kinase Inhibitors in pediatric chronic myeloid leukemia: a focused review of clinical trials Open
Tyrosine Kinase Inhibitors (TKIs) is revolutionizing the management of pediatric Chronic Myeloid Leukemia (CML), offering alternatives to Allogeneic Hematopoietic Stem Cell Transplantation (AHSCT). We conducted a comprehensive review of 16…
View article: The Impact of Ethnicity on the Response to Eltrombopag in Patients With Immune Thrombocytopenia (ITP) in Qatar: A Single Institution Experience
The Impact of Ethnicity on the Response to Eltrombopag in Patients With Immune Thrombocytopenia (ITP) in Qatar: A Single Institution Experience Open
View article: Safety and efficacy of tyrosine kinase inhibitors in pediatric chronic myeloid leukemia: A protocol for systematic review and meta-analysis
Safety and efficacy of tyrosine kinase inhibitors in pediatric chronic myeloid leukemia: A protocol for systematic review and meta-analysis Open
Introduction: Current evidence regarding the efficacy and safety of tyrosine kinase inhibitors in the pediatrics with chronic myeloid leukemia (CML) is limited. The safety of TKI beyond 15years of use has not been studied even in the adult…
View article: Characteristics and Early Predictors of Intensive Care Unit Admission among COVID-19 Patients in Qatar
Characteristics and Early Predictors of Intensive Care Unit Admission among COVID-19 Patients in Qatar Open
Purpose: This study aimed to explore the early predictors of intensive care unit (ICU) admission and in-hospital mortality among patients diagnosed with Coronavirus disease (COVID-19). Methods & Materials: This was a case-control study of …
View article: 395. Early Predictors of Intensive Care Unit Admission among COVID-19 Patients in Qatar
395. Early Predictors of Intensive Care Unit Admission among COVID-19 Patients in Qatar Open
Background Coronavirus disease (COVID-19) is associated with significant morbidity and mortality. This study aimed to explore the early predictors of intensive care unit (ICU) admission and in-hospital mortality among patients diagnosed wi…
View article: Effects of Intermittent Fasting on Response to Tyrosine Kinase Inhibitors (TKIs) in Patients With Chronic Myeloid Leukemia: An Outcome of European LeukemiaNet Project
Effects of Intermittent Fasting on Response to Tyrosine Kinase Inhibitors (TKIs) in Patients With Chronic Myeloid Leukemia: An Outcome of European LeukemiaNet Project Open
The overall survival of patients with Chronic Myeloid Leukemia (CML) treated by using tyrosine kinase inhibitors (TKIs) is very close to that of the healthy population. However, little is known about the effect of specific measures such as…
View article: Tumor lysis syndrome in chronic lymphocytic leukemia: conventional treatment versus novel agents
Tumor lysis syndrome in chronic lymphocytic leukemia: conventional treatment versus novel agents Open
Introduction: Existing evidence on the difference in the incidence of tumor lysis syndrome (TLS) in Chronic Lymphocytic Leukemia (CLL) patients receiving novel therapies versus patients receiving conventional therapies is limited and incon…
View article: Treatment of Tumor Lysis Syndrome in Chronic Lymphocytic Leukemia: Protocol for a systematic review and meta-analysis
Treatment of Tumor Lysis Syndrome in Chronic Lymphocytic Leukemia: Protocol for a systematic review and meta-analysis Open
BackgroundExisting evidence on the difference in the incidence of tumor lysis syndrome (TLS) in Chronic Lymphocytic Leukemia (CLL) patients receiving novel therapies versus patients receiving conventional therapies is limited and inconclus…
View article: Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar
Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar Open
Myeloproliferative neoplasms are a diversified group of diseases of the hematopoietic stem cell, such as essential thrombocythemia (ET) and polycythemia vera. They are mainly caused by mutations in the following genes: JAK2, CALR, a…
View article: Outcome of Pregnancy in the Era of PEGylated Interferon-α2a in Females with Chronic Myeloid Leukemia: An Experience from Qatar
Outcome of Pregnancy in the Era of PEGylated Interferon-α2a in Females with Chronic Myeloid Leukemia: An Experience from Qatar Open
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative neoplasm characterized by increased proliferation of the granulocytic cell line without loss of its capacity to differentiate. It accounts …
View article: Ibrutinib-associated sever skin toxicity: A case of multiple inflamed skin lesions and cellulitis in a 68-year-old male patient with relapsed chronic lymphocytic leukemia – Case report and literature review
Ibrutinib-associated sever skin toxicity: A case of multiple inflamed skin lesions and cellulitis in a 68-year-old male patient with relapsed chronic lymphocytic leukemia – Case report and literature review Open
Introduction Ibrutinib is an oral inhibitor of Bruton’s tyrosine kinase that is used for a variety of B cell hematological malignancies. Skin and subcutaneous tissue manifestations have been reported and were witnessed in up to 32% of the …
View article: Peripheral T-Cell Lymphoma in Adult Female with Rheumatoid Arthritis: Case Report
Peripheral T-Cell Lymphoma in Adult Female with Rheumatoid Arthritis: Case Report Open
Introduction: Lymphoma association with Rheumatoid Arthritis (RA) is well established. The mechanisms behind this association remain a matter of controversy.
Objective: We here report a patient with rheumatoid arthritis who developed peri…
View article: Is Adherence to Imatinib Mesylate Treatment among Patients with Chronic Myeloid Leukemia Associated with Better Clinical Outcomes in Qatar?
Is Adherence to Imatinib Mesylate Treatment among Patients with Chronic Myeloid Leukemia Associated with Better Clinical Outcomes in Qatar? Open
Background Despite the revolutionary success of introducing tyrosine kinase inhibitors (TKIs), such as imatinib mesylate (IM), for treating chronic myeloid leukemia (CML), a substantial proportion of patients’ treatments fail. Aim This stu…