Explanipedia

Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease Open

Lasse Stensvig Madsen, Rola Ismail, Peter Parbo, Pernille Louise Kjeldsen, Jeppe L. Schaldemose , et al. · 2024

INTRODUCTION Microglial responses are an integral part of Alzheimer's disease (AD) pathology and are associated with amyloid beta (Aβ) deposition. This study aimed to investigate the effects of Aβ and microglial responses on global cogniti…

Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment Open

Kristian Juul‐Madsen, Peter Parbo, Rola Ismail, Peter Lund Ovesen, Vanessa Schmidt , et al. · 2024

Capillary dysfunction in healthy elderly <i>APOE ε</i>4 carriers with raised brain Aβ deposition Open

Lasse Stensvig Madsen, Pernille Louise Kjeldsen, Rola Ismail, Peter Parbo, Leif Østergaard , et al. · 2023

INTRODUCTION Capillary dysfunction, characterized by disturbances in capillary blood flow distribution, might be an overlooked factor in the development of Alzheimer's disease (AD). This study investigated microvascular blood flow in precl…

Performance on complex memory tests is associated with β‐amyloid in individuals at risk of developing Alzheimer's disease Open

Pernille Louise Kjeldsen, Malene Flensborg Damholdt, Lasse Stensvig Madsen, Peter H. Nissen, Joel Aanerud , et al. · 2023

The pathophysiological development of Alzheimer's disease (AD) begins in the brain years before the onset of clinical symptoms. The accumulation of beta‐amyloid (Aβ) is thought to be the first cortical pathology to occur. Carrying one apol…

Capillary dysfunction correlates with cortical amyloid load in early Alzheimer's disease Open

Lasse Stensvig Madsen, Peter Parbo, Rola Ismail, Hanne Gottrup, Leif Østergaard , et al. · 2022

Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study Open

Lasse Stensvig Madsen, Rune B. Nielsen, Peter Parbo, Rola Ismail, Irene Klærke Mikkelsen , et al. · 2022

Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET study Open

Pernille Louise Kjeldsen, Peter Parbo, Kim Vang Hansen, Joel Aanerud, Rola Ismail , et al. · 2022

Capillary Dysfunction Correlates with Cortical Amyloid Load in Early Alzheimer's Disease Open

Lasse Stensvig Madsen, Peter Parbo, Rola Ismail, Hanne Gottrup, Leif Østergaard , et al. · 2022

Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease Open

Christopher E. J. Doppler, Martin Byskov Kinnerup, Corinna Brune, Ezequiel Farrher, Matthew J. Betts , et al. · 2021

Previous studies have reported substantial involvement of the noradrenergic system in Parkinson’s disease. Neuromelanin-sensitive MRI sequences and PET tracers have become available to visualize the cell bodies in the locus coeruleus and t…

Preserved noradrenergic function in Parkinson's disease patients with rest tremor Open

Martin Byskov Kinnerup, Michael Sommerauer, Malene Flensborg Damholdt, Jeppe L. Schaldemose, Rola Ismail , et al. · 2021

The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer’s disease: a longitudinal PET study Open

Rola Ismail, Peter Parbo, Lasse Stensvig Madsen, Allan K. Hansen, K. Hansen , et al. · 2020

Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer’s disease Open

Peter Parbo, Lasse Stensvig Madsen, Rola Ismail, Henrik Zetterberg, Kaj Blennow , et al. · 2020

Background Plasma and cerebrospinal fluid levels of neurofilament light (NfL), a marker of axonal degeneration, have previously been reported to be raised in patients with clinically diagnosed Alzheimer’s disease (AD). Activated microglia,…

Impaired perfusion and capillary dysfunction in prodromal Alzheimer's disease Open

Rune B. Nielsen, Peter Parbo, Rola Ismail, Rikke Beese Dalby, Anna Tietze , et al. · 2020

We propose that microvascular flow disturbances antedate cortical atrophy and may limit local tissue oxygenation in pAD. We speculate that capillary dysfunction contributes to the development of neurodegeneration in AD.

The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer’s Disease Open

Rola Ismail, Allan K. Hansen, Peter Parbo, Hans Brændgaard, Hanne Gottrup , et al. · 2018

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. AD pathology is characterized by abnormal aggregation of the proteins amyloid- β (A β ) and hyperphosphorylated tau. No effective disease modifying therapies are current…

Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study Open

Peter Parbo, Rola Ismail, Michael Sommerauer, Morten Gersel Stokholm, Allan K. Hansen , et al. · 2018

Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer’s disease Open

Peter Parbo, Rola Ismail, Kim Vang Hansen, Ali Amidi, Frederik Husum Mårup , et al. · 2017

See Kreisl (doi:10.1093/awx151) for a scientific commentary on this article.Subjects with mild cognitive impairment associated with cortical amyloid-β have a greatly increased risk of progressing to Alzheimer's disease. We hypothesized tha…

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