Roland Assi
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View article: Mechanisms Driving Thoracic Aortic Aneurysm Stability
Mechanisms Driving Thoracic Aortic Aneurysm Stability Open
Thoracic aortic aneurysms (TAAs) arise from a combination of biological and mechanical factors. Current clinical guidelines use size and rate of expansion to stratify risk, but such metrics do not predict if an aneurysm will stabilize, gro…
View article: Importance of localized dilatation and distensibility in identifying determinants of thoracic aortic aneurysm with neural operators
Importance of localized dilatation and distensibility in identifying determinants of thoracic aortic aneurysm with neural operators Open
Thoracic aortic aneurysms (TAAs) stem from diverse mechanical and mechanobiological disruptions to the aortic wall that can also increase the risk of dissection or rupture. There is increasing evidence that dysfunctions along the aortic me…
View article: Importance of localized dilatation and distensibility in identifying determinants of thoracic aortic aneurysm with neural operators
Importance of localized dilatation and distensibility in identifying determinants of thoracic aortic aneurysm with neural operators Open
Thoracic aortic aneurysms (TAAs) arise from diverse mechanical and mechanobiological disruptions to the aortic wall that increase the risk of dissection or rupture. Evidence links TAA development to dysfunctions in the aortic mechanotransd…
View article: Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues
Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues Open
High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq). Fresh-frozen clinical specimens preserve …
View article: Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury
Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury Open
Importance Approximately 30% of US patients develop acute kidney injury (AKI) after cardiac surgery, which is associated with increased morbidity, mortality, and health care costs. The variation in potentially modifiable hospital- and clin…
View article: Endovascular Repair vs Medical Therapy for Uncomplicated Acute Type B Dissection: Aortic Remodeling
Endovascular Repair vs Medical Therapy for Uncomplicated Acute Type B Dissection: Aortic Remodeling Open
TEVAR was associated with favorable aortic remodeling as well as short-term and midterm outcomes compared with optimal medical therapy in patients with uATBAD. The positive remodeling is more pronounced at thoracic aortic levels.
View article: Short-term disruption of TGF-β signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection
Short-term disruption of TGF-β signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection Open
Hypertension and transient increases in blood pressure from extreme exertion are risk factors for aortic dissection in patients with age-related vascular degeneration or inherited connective tissue disorders. Yet, a common experimental mod…
View article: Midterm outcomes of thoracic endovascular aortic repair versus optimal medical therapy for uncomplicated acute type B dissection
Midterm outcomes of thoracic endovascular aortic repair versus optimal medical therapy for uncomplicated acute type B dissection Open
In this single-institution experience, upfront TEVAR performed at index hospitalization for uncomplicated acute type B aortic dissection was associated with improved survival at early and midterm follow-up.
View article: Contemporary Outcomes and Predictors of Adverse Events After Repair of Acute Type A Aortic Dissection: Report From an Aortic Center
Contemporary Outcomes and Predictors of Adverse Events After Repair of Acute Type A Aortic Dissection: Report From an Aortic Center Open
Background: This study evaluates short‐term outcomes in patients undergoing surgery for acute Type A aortic dissection (ATAAD) at a specialized aortic referral center. Methods: Between October 2019 and October 2022, 80 consecutive patients…
View article: Thoracic Aorta Measurement Extraction from Computed Tomography Radiology Reports Using Instruction Tuned Large Language Models
Thoracic Aorta Measurement Extraction from Computed Tomography Radiology Reports Using Instruction Tuned Large Language Models Open
Chest computed tomography (CT) is essential for diagnosing and monitoring thoracic aortic dilations and aneurysms, conditions that place patients at risk of complications such as aortic dissection and rupture. However, aortic measurements …
View article: Surgical treatment and outcomes in aortic valve endocarditis and perivalvular abscesses
Surgical treatment and outcomes in aortic valve endocarditis and perivalvular abscesses Open
Patients with aortic root abscesses experience increased morbidity and mortality compared to those without abscess in aortic valve infective endocarditis. The superior intervention for patients with aortic root abscess is not determined. T…
View article: Transcatheter Aortic Valve Replacement Use in Young Patients Before and After Low-Risk Indication Approval
Transcatheter Aortic Valve Replacement Use in Young Patients Before and After Low-Risk Indication Approval Open
Transcatheter aortic valve replacement (TAVR) use in young patients has recently increased following FDA approval for use in low-risk patients. How TAVR use among young patients may have accelerated in the interval between the FDA approval…
View article: Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption
Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption Open
Smooth muscle cells (SMCs) of cardiac and neural crest origin contribute to the developing proximal aorta and are linked to disease propensity in adults. We analyzed single-cell transcriptomes of SMCs from mature thoracic aortas in mice to…
View article: Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection
Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection Open
Hypertension and transient increases in blood pressure from extreme exertion are risk factors for aortic dissection in patients with age-related vascular degeneration or inherited connective tissue disorders. Yet, the common experimental m…
View article: Intimomedial tears of the aorta heal by smooth muscle cell–mediated fibrosis without atherosclerosis
Intimomedial tears of the aorta heal by smooth muscle cell–mediated fibrosis without atherosclerosis Open
BACKGROUNDDisease of the aorta varies from atherosclerosis to aneurysms, with complications including rupture, dissection, and poorly characterized limited tears. We studied limited tears without any mural hematoma, termed intimomedial tea…
View article: Thoracic aortic aneurysm in an adolescent with intraoperative discovery of contained rupture: a case report
Thoracic aortic aneurysm in an adolescent with intraoperative discovery of contained rupture: a case report Open
As criteria for surgical intervention in adult thoracic ascending aortic aneurysms continues to evolve, this case illustrates challenges when determining the optimal criteria for surgical intervention in adolescent patients.
View article: Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis
Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis Open
To investigate the association between area deprivation index (ADI) and aortic valve replacement (AVR) in patients with severe aortic stenosis (AS). Patients aged 40–95 years with severe AS confirmed by echocardiography were included. The …
View article: Effects of RBT-1 on preconditioning response biomarkers in patients undergoing coronary artery bypass graft or heart valve surgery: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial
Effects of RBT-1 on preconditioning response biomarkers in patients undergoing coronary artery bypass graft or heart valve surgery: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial Open
Renibus Therapeutics, Inc.
View article: Variability in surveillance practice for patients with diagnosis of bicuspid aortic valve syndrome
Variability in surveillance practice for patients with diagnosis of bicuspid aortic valve syndrome Open
In patients with bicuspid aortic valves, guidelines call for regular follow-up to monitor disease progression and guide intervention. We aimed to evaluate how closely these recommendations are followed at a tertiary care center. Among 48,5…
View article: Comprehensive review of hybrid aortic arch repair with focus on zone 0 TEVAR and our institutional experience
Comprehensive review of hybrid aortic arch repair with focus on zone 0 TEVAR and our institutional experience Open
Even with increasing operator experience and a better understanding of the disease and the operation, intervention for aortic arch pathologies continues to struggle with relatively higher mortality, reintervention, and neurologic complicat…
View article: Screening Tool to Identify Patients with Advanced Aortic Valve Stenosis
Screening Tool to Identify Patients with Advanced Aortic Valve Stenosis Open
(1) Background: The clinical burden of aortic stenosis (AS) remains high in Western countries. Yet, there are no screening algorithms for this condition. We developed a risk prediction model to guide targeted screening for patients with AS…
View article: One and Five-Year Mortality Risk Prediction in Patients with Moderate and Severe Aortic Stenosis
One and Five-Year Mortality Risk Prediction in Patients with Moderate and Severe Aortic Stenosis Open
(1) Background: Our goal was to develop a risk prediction model for mortality in patients with moderate and severe aortic stenosis (AS). (2) Methods: All patients aged 40–95 years, with echocardiographic evidence of moderate and severe AS …