Roland Matsouaka
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View article: Variance Estimation for Weighted Average Treatment Effects
Variance Estimation for Weighted Average Treatment Effects Open
Common variance estimation methods for weighted average treatment effects (WATEs) in observational studies include nonparametric bootstrap and model-based, closed-form sandwich variance estimation. However, the computational cost of bootst…
View article: Development of Common Data Elements for Organ Transplantation
Development of Common Data Elements for Organ Transplantation Open
This cohort study examines the validity of an electronic health record data model for organ transplantation.
View article: Assessing racial disparities in healthcare expenditure using generalized propensity score weighting
Assessing racial disparities in healthcare expenditure using generalized propensity score weighting Open
We found that generalized propensity score weighting (GPSW) methods are valuable quantitative tools to standardize and compare characteristics as well as outcomes of non-manipulable groups. This helps assess disparities across multiple rac…
View article: A data pipeline for secure extraction and sharing of social determinants of health
A data pipeline for secure extraction and sharing of social determinants of health Open
Objectives Linking neighborhood- and patient-level data provides valuable information about the influence of upstream social determinants of health (SDOH). However, sharing of these data across health systems presents challenges. We set ou…
View article: When does adjusting covariate under randomization help? A comparative study on current practices
When does adjusting covariate under randomization help? A comparative study on current practices Open
View article: Observations from Statistical Review Editors: A Commentary
Observations from Statistical Review Editors: A Commentary Open
Reproducibility and replicability are crucial components of the scientific method, but they may be compromised when there are inherent issues related to a study and analytic choices such as statistical errors or misalignments between the s…
View article: Overlap, matching, or entropy weights: what are we weighting for?
Overlap, matching, or entropy weights: what are we weighting for? Open
There has been a recent surge in statistical methods for handling the lack of adequate positivity when using inverse probability weights (IPW). However, these nascent developments have raised a number of questions. Thus, we demonstrate the…
View article: Defining the Need for Causal Inference to Understand the Impact of Social Determinants of Health: A Primer on Behalf of the Consortium for the Holistic Assessment of Risk in Transplantation (CHART)
Defining the Need for Causal Inference to Understand the Impact of Social Determinants of Health: A Primer on Behalf of the Consortium for the Holistic Assessment of Risk in Transplantation (CHART) Open
Objective: This study aims to introduce key concepts and methods that inform the design of studies that seek to quantify the causal effect of social determinants of health (SDOH) on access to and outcomes following organ transplant. Backgr…
View article: Average treatment effect on the treated, under lack of positivity
Average treatment effect on the treated, under lack of positivity Open
The use of propensity score (PS) methods has become ubiquitous in causal inference. At the heart of these methods is the positivity assumption. Violation of the positivity assumption leads to the presence of extreme PS weights when estimat…
View article: Recent Vitamin K Antagonist Use and Intracranial Hemorrhage After Endovascular Thrombectomy for Acute Ischemic Stroke
Recent Vitamin K Antagonist Use and Intracranial Hemorrhage After Endovascular Thrombectomy for Acute Ischemic Stroke Open
Importance Use of oral vitamin K antagonists (VKAs) may place patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke caused by large vessel occlusion at increased risk of complications. Objective To determine the ass…
View article: Addressing substantial covariate imbalance with propensity score stratification and balancing weights: connections and recommendations
Addressing substantial covariate imbalance with propensity score stratification and balancing weights: connections and recommendations Open
Objectives Propensity score (PS) weighting methods are commonly used to adjust for confounding in observational treatment comparisons. However, in the setting of substantial covariate imbalance, PS values may approach 0 and 1, yielding ext…
View article: Neighborhood Socioeconomic Disadvantage and Hospitalized Heart Failure Outcomes in the American Heart Association Get With The Guidelines-Heart Failure Registry
Neighborhood Socioeconomic Disadvantage and Hospitalized Heart Failure Outcomes in the American Heart Association Get With The Guidelines-Heart Failure Registry Open
Background: Neighborhood socioeconomic status (SES) is associated with worse health outcomes, yet its relationship with in-hospital heart failure (HF) outcomes and quality metrics are underexplored. We examined the association between soci…
View article: Variance estimation for the average treatment effects on the treated and on the controls
Variance estimation for the average treatment effects on the treated and on the controls Open
Common causal estimands include the average treatment effect (ATE), the average treatment effect of the treated (ATT), and the average treatment effect on the controls (ATC). Using augmented inverse probability weighting methods, parametri…
View article: Analysis of Prescriptions for Dual Antiplatelet Therapy After Acute Ischemic Stroke
Analysis of Prescriptions for Dual Antiplatelet Therapy After Acute Ischemic Stroke Open
This cohort study found that despite updated AHA/ASA guidelines, more than 50% of patients with minor acute ischemic stroke did not receive DAPT at discharge. In contrast, more than 40% of patients with nonminor stroke received DAPT despit…
View article: Sex Differences in Endovascular Therapy for Ischemic Stroke: Results From the Get With The Guidelines–Stroke Registry
Sex Differences in Endovascular Therapy for Ischemic Stroke: Results From the Get With The Guidelines–Stroke Registry Open
Background: In 2015, endovascular therapy (EVT) for large vessel occlusions became standard of care for acute ischemic stroke. Lower utilization of IV alteplase has been reported in women, but whether sex differences in EVT use in the Unit…
View article: US Surveillance of Acute Ischemic Stroke Patient Characteristics, Care Quality, and Outcomes for 2019
US Surveillance of Acute Ischemic Stroke Patient Characteristics, Care Quality, and Outcomes for 2019 Open
Background: The United States lacks a timely and accurate nationwide surveillance system for acute ischemic stroke (AIS). We use the Get With The Guidelines-Stroke registry to apply poststratification survey weights to generate national as…
View article: Outcomes After Endovascular Thrombectomy With or Without Alteplase in Routine Clinical Practice
Outcomes After Endovascular Thrombectomy With or Without Alteplase in Routine Clinical Practice Open
In this observational cohort study of patients treated with EVT, intravenous alteplase treatment was associated with better in-hospital survival and functional outcomes but higher sICH risk after adjusting for other covariates.
View article: Trends in Use, Outcomes, and Disparities in Endovascular Thrombectomy in US Patients With Stroke Aged 80 Years and Older Compared With Younger Patients
Trends in Use, Outcomes, and Disparities in Endovascular Thrombectomy in US Patients With Stroke Aged 80 Years and Older Compared With Younger Patients Open
In this cohort study, use of EVT among individuals aged 80 years and older increased substantially from 2012 to 2019, although the rate remained lower than in younger patients. Although favorable functional outcomes at discharge were lower…
View article: Seasonal Variation of Atrial Fibrillation Admission and Quality of Care in the United States
Seasonal Variation of Atrial Fibrillation Admission and Quality of Care in the United States Open
Background Currently, little is known regarding seasonal variation for atrial fibrillation (AF) in the United States and whether quality of care for AF varies between seasons. Methods and Results The GWTG‐AFib (Get With The Guidelines–AFib…
View article: Association of Recent Use of Non–Vitamin K Antagonist Oral Anticoagulants With Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase
Association of Recent Use of Non–Vitamin K Antagonist Oral Anticoagulants With Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase Open
Among patients with acute ischemic stroke treated with intravenous alteplase, use of NOACs within the preceding 7 days, compared with no use of anticoagulants, was not associated with a significantly increased risk of intracranial hemorrha…
View article: Trimethoprim-Sulfamethoxazole Versus Levofloxacin for <i>Stenotrophomonas maltophilia</i> Infections: A Retrospective Comparative Effectiveness Study of Electronic Health Records from 154 US Hospitals
Trimethoprim-Sulfamethoxazole Versus Levofloxacin for <i>Stenotrophomonas maltophilia</i> Infections: A Retrospective Comparative Effectiveness Study of Electronic Health Records from 154 US Hospitals Open
Background Trimethoprim-sulfamethoxazole (TMP-SMX) is considered first-line therapy for Stenotrophomonas maltophilia infections based on observational data from small studies. Levofloxacin has emerged as a popular alternative due to tolera…
View article: Exploring the Unmet Need in Acute Ischemic Stroke Patients Not Treated With Intravenous Alteplase: The Get With The Guidelines‐Stroke Registry
Exploring the Unmet Need in Acute Ischemic Stroke Patients Not Treated With Intravenous Alteplase: The Get With The Guidelines‐Stroke Registry Open
Background Early administration of intravenous tissue plasminogen activator (IV alteplase) improves functional outcomes in patients with acute ischemic stroke, yet many patients are not treated with IV alteplase. There is a need to underst…
View article: Association of readmission penalty amount with subsequent 30-day risk standardized readmission and mortality rates among patients hospitalized with heart failure: An analysis of get with the guidelines – heart failure participating centers
Association of readmission penalty amount with subsequent 30-day risk standardized readmission and mortality rates among patients hospitalized with heart failure: An analysis of get with the guidelines – heart failure participating centers Open
Financial penalties based on 30-day RSRR are not associated with declines in 30-day RSRR or RSMR from 2012 to 2015 among patients hospitalized with HF. Financially penalizing hospitals based on current Hospital Readmissions Reduction Progr…
View article: Achievement and quality measure attainment in patients hospitalized with atrial fibrillation: Results from The Get With The Guidelines – Atrial Fibrillation (GWTG-AFIB) registry
Achievement and quality measure attainment in patients hospitalized with atrial fibrillation: Results from The Get With The Guidelines – Atrial Fibrillation (GWTG-AFIB) registry Open
View article: Is the affordable care act medicaid expansion associated with receipt of heart failure guideline-directed medical therapy by race and ethnicity?
Is the affordable care act medicaid expansion associated with receipt of heart failure guideline-directed medical therapy by race and ethnicity? Open
View article: Associations of Medicaid Expansion With Access to Care, Severity, and Outcomes for Acute Ischemic Stroke
Associations of Medicaid Expansion With Access to Care, Severity, and Outcomes for Acute Ischemic Stroke Open
Background: Multiple states have not expanded Medicaid under the Affordable Care Act, resulting in higher uninsured rates in states with high stroke burdens. This study aimed to evaluate the association of Medicaid expansion with changes i…
View article: Noninvasive Risk Score to Screen for Pulmonary Hypertension With Elevated Pulmonary Vascular Resistance in Diseases of Chronic Volume Overload
Noninvasive Risk Score to Screen for Pulmonary Hypertension With Elevated Pulmonary Vascular Resistance in Diseases of Chronic Volume Overload Open
View article: Patterns of etanercept use in juvenile idiopathic arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry
Patterns of etanercept use in juvenile idiopathic arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry Open
View article: Association Between 2010 Medicare Reform and Inpatient Rehabilitation Access in People With Intracerebral Hemorrhage
Association Between 2010 Medicare Reform and Inpatient Rehabilitation Access in People With Intracerebral Hemorrhage Open
Background Evidence suggests intracerebral hemorrhage survivors have earlier recovery compared with ischemic stroke survivors. The Centers for Medicare and Medicaid Services prospective payment system instituted documentation rules for inp…
View article: Association of Provider Perspectives on Race and Racial Health Care Disparities with Patient Perceptions of Care and Health Outcomes
Association of Provider Perspectives on Race and Racial Health Care Disparities with Patient Perceptions of Care and Health Outcomes Open
Purpose: Research suggests that providers contribute to racial disparities in health outcomes. Identifying modifiable provider perspectives that are associated with decreased racial disparities will help in the design of effective e…