Roma Chilengi
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View article: Diagnostic Stewardship Trends and Antimicrobial Resistance Profiles of Bacteria Isolated in Zambia: A Five-Year Retrospective Study (2020–2024)
Diagnostic Stewardship Trends and Antimicrobial Resistance Profiles of Bacteria Isolated in Zambia: A Five-Year Retrospective Study (2020–2024) Open
Background/Objectives: The right diagnostic tests, for the right patient, at the right time, are key to optimising antimicrobial use (AMU) and preventing antimicrobial resistance (AMR). This study evaluated diagnostic stewardship trends an…
View article: Impact of Multidisciplinary-Led Implementation of Antimicrobial Stewardship Programs in Zambia: Findings and Implications
Impact of Multidisciplinary-Led Implementation of Antimicrobial Stewardship Programs in Zambia: Findings and Implications Open
Background/Objectives: Antimicrobial resistance (AMR) is a critical global health threat, with sub-Saharan Africa disproportionately affected. Antimicrobial stewardship (AMS) programs are essential in combating AMR; however, data on their …
View article: Antimicrobial Consumption and Utilisation in Zambia: Results from the Analysis of National Data for the Human and Animal Health Sectors
Antimicrobial Consumption and Utilisation in Zambia: Results from the Analysis of National Data for the Human and Animal Health Sectors Open
Background/Objectives: Antimicrobial Resistance (AMR) remains a growing public health threat, underscoring the need for robust surveillance of Antimicrobial Consumption (AMC) and Antimicrobial Use (AMU). This study analysed AMC and AMU tre…
View article: The first Mpox case in Zambia: a case report
The first Mpox case in Zambia: a case report Open
View article: Antimicrobial Resistance Profiles of Bacteria Isolated from the Animal Health Sector in Zambia (2020–2024): Opportunities to Strengthen Antimicrobial Resistance Surveillance and Stewardship Programs
Antimicrobial Resistance Profiles of Bacteria Isolated from the Animal Health Sector in Zambia (2020–2024): Opportunities to Strengthen Antimicrobial Resistance Surveillance and Stewardship Programs Open
Background/Objectives: Antimicrobial resistance (AMR) is a major global health threat that undermines treatment in humans and animals. In Zambia, where livestock production underpins food security and livelihoods, AMR challenges are aggrav…
View article: Antimicrobial Stewardship Program Implementation, Perceptions, and Barriers in Zambia: A Cross-Sectional Study Among Healthcare Professionals
Antimicrobial Stewardship Program Implementation, Perceptions, and Barriers in Zambia: A Cross-Sectional Study Among Healthcare Professionals Open
Background/Objectives: Antimicrobial stewardship programs (ASPs) play a vital role in combating antimicrobial resistance (AMR). However, their implementation in Zambia remains variable despite some notable progress. This study assessed hea…
View article: Development of the Zambian Standard Treatment Guidelines in the Animal Health Sector: A Key Step in Advancing Antimicrobial Stewardship
Development of the Zambian Standard Treatment Guidelines in the Animal Health Sector: A Key Step in Advancing Antimicrobial Stewardship Open
Background: Zambia, like many low- and middle-income countries, faces a growing burden of antimicrobial resistance (AMR), driven by the misuse of antimicrobials in both human and animal health, a limited diagnostic capacity, and weak regul…
View article: Prevalence and Patterns of Enteric Co-Infections Among Individuals Presenting with Cholera-like Diarrheal Disease During Seasonal Cholera Outbreaks
Prevalence and Patterns of Enteric Co-Infections Among Individuals Presenting with Cholera-like Diarrheal Disease During Seasonal Cholera Outbreaks Open
Cholera remains a major public health challenge, and co-infections can complicate out-comes and case management. In a cross-sectional study, we investigated the prevalence and patterns of enteric co-infections during Zambia’s 2023–2024 cho…
View article: Evaluation of plasma anti-CS3 and anti-LTB IgG avidity among Zambian children vaccinated with ETVAX
Evaluation of plasma anti-CS3 and anti-LTB IgG avidity among Zambian children vaccinated with ETVAX Open
Background: Enterotoxigenic Escherichia coli (ETEC) remains a major cause of diarrheal disease in low- and middle-income countries (LMICs). To curb ETEC related diarrhoea, several candidate vaccines are in development, with ETVAX® being th…
View article: A new era of political-technical synergy in Africa’s cholera response
A new era of political-technical synergy in Africa’s cholera response Open
No abstract available.
View article: Descriptive study of cholera-related deaths in communities during Zambia’s 2023–2024 outbreak: key insights
Descriptive study of cholera-related deaths in communities during Zambia’s 2023–2024 outbreak: key insights Open
Objectives The study sought to understand the characteristics of community deaths due to cholera in Zambia. We sought to examine the drivers of mortality from cholera among communities in Zambia’s 2023–2024 outbreak. Design/setting This is…
View article: No evidence of MMR induced trained immunity to prevent SARS COV2: results from a multi-centre RCT
No evidence of MMR induced trained immunity to prevent SARS COV2: results from a multi-centre RCT Open
Background Measles-containing vaccines (MCV), by training innate immune cells, are hypothesized to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19). Methods In this inte…
View article: Safety, immunogenicity, and relative efficacy of a parenteral trivalent rotavirus subunit vaccine candidate (TV P2-VP8) in healthy Ghanaian, Malawian, and Zambian infants
Safety, immunogenicity, and relative efficacy of a parenteral trivalent rotavirus subunit vaccine candidate (TV P2-VP8) in healthy Ghanaian, Malawian, and Zambian infants Open
Background While live oral rotavirus vaccines (LORVs) are effective at preventing severe rotavirus gastroenteritis (SRVGE), they perform sub-optimally in the settings with the highest burden. Parenteral rotavirus vaccines could have greate…
View article: In silico characterization of chromosomally integrated blaCTX-M genes among clinical Enterobacteriaceae in Africa: insights from whole-genome analysis
In silico characterization of chromosomally integrated blaCTX-M genes among clinical Enterobacteriaceae in Africa: insights from whole-genome analysis Open
Antimicrobial resistance (AMR) mediated by extended-spectrum β -lactamases (ESBLs) is a growing global concern, particularly among Enterobacteriaceae . The CTX-M-type ESBLs, encoded by the bla CTX-M gene, are of significant public health i…
View article: Evaluating infection prevention and control programs in Zambian hospitals using the WHO infection prevention and control assessment framework tool
Evaluating infection prevention and control programs in Zambian hospitals using the WHO infection prevention and control assessment framework tool Open
Background Infection Prevention and Control (IPC) is key to preventing healthcare-associated infections (HAIs) and the spread of antimicrobial resistance (AMR). This study evaluated the implementation of IPC in Zambian hospitals. Materials…
View article: Impacts of US Bilateral Aid Disruptions on HIV Resurgence in Zambia: A Mathematical Modeling Study
Impacts of US Bilateral Aid Disruptions on HIV Resurgence in Zambia: A Mathematical Modeling Study Open
Background Of countries with high HIV prevalence, Zambia had the largest proportion of funding to its HIV program from the United States President's Emergency Plan for AIDS Relief (PEPFAR)—84% at the start of 2025. Abrupt withdrawal of bil…
View article: Corrigendum to ‘Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study’. EBioMedicine 2024;108: 105320
Corrigendum to ‘Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study’. EBioMedicine 2024;108: 105320 Open
View article: A continental call to action to end cholera by 2030
A continental call to action to end cholera by 2030 Open
View article: Enhancing Disease Surveillance: Zambia’s Cholera Tracker 2019 to 2024
Enhancing Disease Surveillance: Zambia’s Cholera Tracker 2019 to 2024 Open
Introduction In Zambia, managing outbreak data, as exemplified by recent crises like Cholera and Covid-19, has presented significant challenges. The 2023-2024 cholera outbreak alone recorded over 23,221 cases and 740 deaths. To address thi…
View article: Navigating the cholera elimination roadmap in Zambia – A scoping review (2013–2024)
Navigating the cholera elimination roadmap in Zambia – A scoping review (2013–2024) Open
Background Cholera outbreaks are increasing in frequency and severity, particularly in Sub-Saharan Africa. Zambia, committed to ending cholera by 2025, instead experienced its most significant outbreak in 2024. This review examines the per…
View article: Present or Absent: Risks and protective factors of sudden infant death syndrome (SIDS) in the Zambian context
Present or Absent: Risks and protective factors of sudden infant death syndrome (SIDS) in the Zambian context Open
View article: Clinical Characteristics of 6578 Adult Patients With Cholera Admitted to Community and Referral Cholera Treatment Centers in Lusaka, Zambia, October 2023 to April 2024
Clinical Characteristics of 6578 Adult Patients With Cholera Admitted to Community and Referral Cholera Treatment Centers in Lusaka, Zambia, October 2023 to April 2024 Open
Background Zambia experienced the largest cholera outbreak in the country history in 2023–2024 in the capital, Lusaka. This study aimed to identify the clinical characteristics of the adult patients hospitalized at the community and referr…
View article: Current status and future direction of antimicrobial stewardship programs and antibiotic prescribing in primary care hospitals in Zambia
Current status and future direction of antimicrobial stewardship programs and antibiotic prescribing in primary care hospitals in Zambia Open
Background Antimicrobial Stewardship Programs (ASPs) intended to optimize antibiotic use will be more effective if informed by the current status and patterns of antibiotic utilisation. In Zambia's primary healthcare (PHC) settings, data o…
View article: Attention to COVID 19 pandemic resulted in increased measles cases and deaths in Zambia
Attention to COVID 19 pandemic resulted in increased measles cases and deaths in Zambia Open
View article: Factors associated with measles vaccine immunogenicity in children at University Teaching Hospitals, Lusaka, Zambia
Factors associated with measles vaccine immunogenicity in children at University Teaching Hospitals, Lusaka, Zambia Open
Measles poses a significant global public health challenge, particularly in low-resource settings where vaccination coverage is limited. This study examined factors associated with measles vaccine immunogenicity in children aged 2–15 years…
View article: Clinical Characteristics and Factors Associated With Severe Outcomes of 1891 Pediatric Patients Admitted to the Referral Cholera Treatment Centers in Lusaka, Zambia, December 2023–March 2024
Clinical Characteristics and Factors Associated With Severe Outcomes of 1891 Pediatric Patients Admitted to the Referral Cholera Treatment Centers in Lusaka, Zambia, December 2023–March 2024 Open
Background Zambia declared a cholera outbreak on 18 October 2023 and, as of 31 June 2024, had recorded 23 381 cases and 740 deaths. Of the patients seen at the 2 main cholera treatment centers in the capital Lusaka, a third of them were ch…
View article: Geospatial analysis of cholera outbreak in Lusaka, Zambia, between 2023 and 2024
Geospatial analysis of cholera outbreak in Lusaka, Zambia, between 2023 and 2024 Open
Background Cholera outbreaks have plagued Zambia for decades, with Lusaka district, the capital, being particularly vulnerable. Although the lack of sanitary toilet facilities and inadequate drainage systems were shown to be associated wit…
View article: Whole genome characterisation of Enterotoxigenic<i>Escherichia coli</i>circulating in Zambia
Whole genome characterisation of Enterotoxigenic<i>Escherichia coli</i>circulating in Zambia Open
Background Enterotoxigenic Escherichia coli (ETEC) is a significant cause of diarrheal disease, particularly in low—and middle-income countries, including Zambia. ETEC pathogenesis is driven by colonisation factors (CF) and enterotoxins, a…
View article: Risk of hospitalization or death does not differ in children exposed to HIV, yet uninfected compared to nonexposed peers in Lusaka, Zambia
Risk of hospitalization or death does not differ in children exposed to HIV, yet uninfected compared to nonexposed peers in Lusaka, Zambia Open
Objective: Increased mortality and morbidity has been observed among children who are HIV-exposed, uninfected (CHEU). It is unknown if health disparities remain despite promotion of exclusive breastfeeding and adoption of universal combina…
View article: Point Prevalence Survey of Antibiotic Use in Level 1 hospitals in Zambia: Future Prospects for Antimicrobial Stewardship Programs
Point Prevalence Survey of Antibiotic Use in Level 1 hospitals in Zambia: Future Prospects for Antimicrobial Stewardship Programs Open
This study found a high use of antibiotics and low adherence to treatment guidelines in level 1 hospitals in Lusaka, Zambia. The findings of this study demonstrate the need to establish and strengthen antimicrobial stewardship programs and…