Romain Chopard
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View article: Large-bore mechanical thrombectomy vs standard of care for acute high-risk pulmonary embolism: rationale and design of the PERSEVERE randomized controlled trial
Large-bore mechanical thrombectomy vs standard of care for acute high-risk pulmonary embolism: rationale and design of the PERSEVERE randomized controlled trial Open
The PERSEVERE study will assess the potential superiority of LBMT over SoC for the treatment of High-Risk PE.
View article: Diagnostic yield of referring patients for invasive coronary angiography primarily based on high CAC scores: Positive predictive value for obstructive coronary artery disease in a consecutive real-life cohort
Diagnostic yield of referring patients for invasive coronary angiography primarily based on high CAC scores: Positive predictive value for obstructive coronary artery disease in a consecutive real-life cohort Open
Even at extreme thresholds (>2000 AU), CAC alone did not reliably identify oCAD in patients with low to moderate RF-CL. CAC remains valuable for refining pre-test probability and guiding the selection of appropriate non-invasive testing.
View article: Dual Percutaneous Repair for Aortic Annulus Rupture After Balloon-Expandable TAVR
Dual Percutaneous Repair for Aortic Annulus Rupture After Balloon-Expandable TAVR Open
Annulus rupture is a rare but critical TAVR complication. Rapid diagnosis and multidisciplinary coordination are essential. Percutaneous strategies, including valve-in-valve and coil embolization, may be lifesaving in selected cases.
View article: The STRAT Clinical Risk Score to Predict Early Ischemic Stroke Post-TAVI: findings from the FRANCE-TAVI registry
The STRAT Clinical Risk Score to Predict Early Ischemic Stroke Post-TAVI: findings from the FRANCE-TAVI registry Open
Background Practitioners recommending transcatheter aortic valve implantation (TAVI) currently lack reliable tools to predict periprocedural ischemic stroke risk. We aimed to develop and internally validate a clinical risk score to accurat…
View article: Presence of both elevated brain natriuretic peptide level and anemia is highly predictive of one-year mortality in stable chronic heart failure: Results from a single center cohort analysis
Presence of both elevated brain natriuretic peptide level and anemia is highly predictive of one-year mortality in stable chronic heart failure: Results from a single center cohort analysis Open
Background We investigated whether the simultaneous presence of both elevated BNP and anemia would improve prediction of one-year mortality compared to the MAGGIC score, in patients with stable chronic heart failure (CHF). Methods Single-c…
View article: Right Ventricular Pseudoaneurysm
Right Ventricular Pseudoaneurysm Open
Right ventricular pseudoaneurysm is a rare and poorly documented condition that can complicate even a routine procedure (eg, central venous line placement). Due to its lethal potential, treatment is primarily interventional, requiring care…
View article: Intercontinental variations in the presentation and management of venous thromboembolism
Intercontinental variations in the presentation and management of venous thromboembolism Open
Objective: Venous thromboembolism (VTE) is a global disease with significant morbidity and mortality. However, variations in presentation and management of VTE between different continents have not been studied. This retrospective analysis…
View article: Surgery versus thrombolytic therapy for the management of left-sided prosthetic valve thrombosis without hemodynamic compromise: a systematic review and meta-analysis
Surgery versus thrombolytic therapy for the management of left-sided prosthetic valve thrombosis without hemodynamic compromise: a systematic review and meta-analysis Open
Background The optimal strategy in prosthetic heart valve thrombosis (PVT) remains controversial, with no randomized trials and conflicting observational data. Objectives To perform a systematic review and meta-analysis of evidence compari…
View article: Surgery Versus Thrombolytic Therapy for the Management of Left‐Sided Prosthetic Valve Thrombosis Without Hemodynamic Compromise: A Systematic Review and Meta‐Analysis
Surgery Versus Thrombolytic Therapy for the Management of Left‐Sided Prosthetic Valve Thrombosis Without Hemodynamic Compromise: A Systematic Review and Meta‐Analysis Open
Background The optimal strategy in prosthetic heart valve thrombosis (PVT) remains controversial, with no randomized trials and conflicting observational data. We performed a systematic review and meta‐analysis of evidence comparing system…
View article: Risk of recurrence after discontinuing anticoagulation in patients with COVID-19- associated venous thromboembolism: a prospective multicentre cohort study
Risk of recurrence after discontinuing anticoagulation in patients with COVID-19- associated venous thromboembolism: a prospective multicentre cohort study Open
Sanofi and Rovi, Sanofi Spain.
View article: Strike Early and Strike Strong: application of a strategy comprising first-line combination of high-intensity statins and ezetimibe for patients with acute myocardial infarction in routine practice
Strike Early and Strike Strong: application of a strategy comprising first-line combination of high-intensity statins and ezetimibe for patients with acute myocardial infarction in routine practice Open
Aim Rapid and intense LDL-c reduction for patients with acute myocardial infarction (AMI) using a systematic combination of high intensity statins and ezetimibe, dubbed "Strike Early and Strike Strong" (SESS), has been proposed in a positi…
View article: Incidence of atrial fibrillation in cryptogenic stroke with patent foramen ovale closure: protocol for the prospective, observational PFO-AF study
Incidence of atrial fibrillation in cryptogenic stroke with patent foramen ovale closure: protocol for the prospective, observational PFO-AF study Open
Introduction After closure of patent foramen ovale (PFO) due to stroke, atrial fibrillation (AF) occurs in up to one in five patients. However, data are sparse regarding the possible pre-existence of AF in these patients prior to PFO closu…
View article: Trends in management and outcomes of pulmonary embolism with a multidisciplinary response team
Trends in management and outcomes of pulmonary embolism with a multidisciplinary response team Open
Background Multidisciplinary pulmonary embolism (PE) response teams have garnered widespread adoption given the complexities of managing acute PE and provide a platform for assessment of trends in therapy and outcomes. We aimed to describe…
View article: An Update on the Management of Acute High-Risk Pulmonary Embolism
An Update on the Management of Acute High-Risk Pulmonary Embolism Open
Hemodynamic instability and right ventricular (RV) dysfunction are the key determinants of short-term prognosis in patients with acute pulmonary embolism (PE). High-risk PE encompasses a wide spectrum of clinical situations from sustained …
View article: Extended Anticoagulation After Pulmonary Embolism: A Multicenter Observational Cohort Analysis
Extended Anticoagulation After Pulmonary Embolism: A Multicenter Observational Cohort Analysis Open
Background Pulmonary embolism (PE) has a long‐term risk of adverse events, which can be prevented by extended anticoagulation. We compared clinical characteristics and outcomes between patients treated with 2‐year extended anticoagulation …
View article: Assessment of cognitive dysfunction using the Montreal Cognitive Assessment test: rate, severity and comparison with the Clock test alone in a population of patients referred for TAVI
Assessment of cognitive dysfunction using the Montreal Cognitive Assessment test: rate, severity and comparison with the Clock test alone in a population of patients referred for TAVI Open
Background Although not recommended in routine practice, the detection and quantification of Cognitive Dysfunction (CD) in older patients might have an impact on clinical decisions. We assessed the rate and severity of CD in an unselected …
View article: An original risk score to predict early major bleeding in acute pulmonary embolism: the Syncope, Anemia, Renal Dysfunction (PE-SARD) bleeding score
An original risk score to predict early major bleeding in acute pulmonary embolism: the Syncope, Anemia, Renal Dysfunction (PE-SARD) bleeding score Open
Background Improved prediction of the risk of early major bleeding in pulmonary embolism (PE) is needed to optimize acute management. Methods Using data from a multicenter prospective registry including 2,754 patients, we performed multiva…
View article: Assessment of cognitive dysfunction using the Montreal Cognitive Assessment test: rate, severity and comparison with the Clock test alone in a population of patients referred for TAVI
Assessment of cognitive dysfunction using the Montreal Cognitive Assessment test: rate, severity and comparison with the Clock test alone in a population of patients referred for TAVI Open
Background Although not recommended in routine practice, the detection and quantification of Cognitive Dysfunction (CD) in older patients might have an impact on clinical decisions. We assessed the rate and severity of CD in an unselected …
View article: Available bleeding scoring systems poorly predict major bleeding in the acute phase of pulmonary embolism
Available bleeding scoring systems poorly predict major bleeding in the acute phase of pulmonary embolism Open
Background Bleeding prediction scores may help to guide acute management of patients with pulmonary embolism (PE). However, existing scoring systems have not been validated for in-hospital assessment. We aimed to compare 6 available bleedi…
View article: Use of mechanical pulmonary reperfusion and fibrinolysis in acute massive pulmonary embolism requiring extracorporeal membrane oxygenation support: a systematic review and meta-analysis
Use of mechanical pulmonary reperfusion and fibrinolysis in acute massive pulmonary embolism requiring extracorporeal membrane oxygenation support: a systematic review and meta-analysis Open
Background and objectives The optimal pulmonary revascularization strategy in acute massive pulmonary embolism (PE) requiring the implantation extra corporeal membrane oxygenation remains controversial, and data are sparse. Methods We cond…
View article: Cognitive dysfunction among patients referred for transcatheter aortic valve implantation: results of the Montreal Cognitive Assessment and clinical impact at 6 months
Cognitive dysfunction among patients referred for transcatheter aortic valve implantation: results of the Montreal Cognitive Assessment and clinical impact at 6 months Open
Background Detection of Cognitive Dysfunction (CD) is not routinely performed among patients undergoing Transcatheter Aortic Valve Implantation (TAVI). We sought to determine whether CD has an impact on the clinical course of these patient…
View article: Available Bleeding Scoring Systems Poorly Predict Major Bleeding in the Acute Phase of Pulmonary Embolism
Available Bleeding Scoring Systems Poorly Predict Major Bleeding in the Acute Phase of Pulmonary Embolism Open
We aimed to compare six available bleeding scores, in a real-life cohort, for prediction of major bleeding in the early phase of pulmonary embolism (PE). We recorded in-hospital characteristics of 2754 PE patients in a prospective observat…
View article: Impact of early (<7 days) pacemaker implantation after cardiac surgery on long‐term pacemaker dependency
Impact of early (<7 days) pacemaker implantation after cardiac surgery on long‐term pacemaker dependency Open
Objective We aimed to investigate pacemaker dependency after at least 1 year in patients with early (12 months) pacemaker dependency, but is associated with shorter length of stay and less frequent new‐onset AF. These findings warrant pros…
View article: Elevated D-dimers and lack of anticoagulation predict PE in severe COVID-19 patients
Elevated D-dimers and lack of anticoagulation predict PE in severe COVID-19 patients Open
Background Coronavirus disease 2019 (COVID-19) may predispose to venous thromboembolism. We determined factors independently associated with computed tomography pulmonary angiography (CTPA)-confirmed pulmonary embolism (PE) in hospitalised…