Romain Hamelin
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View article: Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation
Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation Open
View article: An updated proteomic analysis of <i>Drosophila</i> haemolymph after bacterial infection
An updated proteomic analysis of <i>Drosophila</i> haemolymph after bacterial infection Open
Using an in-depth Mass Spectrometry-based proteomics approach, we provide a comprehensive characterization of the hemolymphatic proteome of adult flies upon bacterial infection. We detected and quantified changes in abundance of several kn…
View article: Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion
Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion Open
Placental malaria is characterized by the massive accumulation and sequestration of infected erythrocytes in the placental intervillous blood spaces, causing severe birth outcomes. The variant surface antigen VAR2CSA is associated with Pla…
View article: An updated proteomic analysis of<i>Drosophila</i>hemolymph after bacterial infection
An updated proteomic analysis of<i>Drosophila</i>hemolymph after bacterial infection Open
Using an in-depth Mass Spectrometry based proteomics approach, we provide a comprehensivecharacterization of the hemolymphatic proteome of adult flies upon bacterial infection. We detected and quantified changes in abundance of several kno…
View article: Dissecting the differential role of C-terminal truncations in the regulation of aSyn pathology formation and the biogenesis of Lewy bodies
Dissecting the differential role of C-terminal truncations in the regulation of aSyn pathology formation and the biogenesis of Lewy bodies Open
Alpha-synuclein (aSyn) post-translational modifications (PTMs), particularly phosphorylation at serine 129 and C-terminal truncations, are highly enriched in Lewy bodies (LBs), Lewy neurites, and other types of aSyn pathological aggregates…
View article: Conditional essentiality of the 11-subunit complex I-like enzyme in strict anaerobes: the case of Desulfitobacterium hafniense strain DCB-2
Conditional essentiality of the 11-subunit complex I-like enzyme in strict anaerobes: the case of Desulfitobacterium hafniense strain DCB-2 Open
In oxidative phosphorylation, respiratory complex I serves as an entry point in the electron transport chain for electrons generated in catabolic processes in the form of NADH. An ancestral version of the complex, lacking the NADH-oxidisin…
View article: Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor
Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor Open
The process of protein phosphorylation is involved in numerous cell functions. In particular, phosphotyrosine (pY) has been reported to play a role in red blood cell (RBC) functions, including the cytoskeleton organization. During their st…
View article: Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia
Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia Open
Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T-cell acute lymphoblastic leukemia (T-ALL), highlighting the Notch signaling pathway as a promising therapeutic target for personalized medicine. Yet,…
View article: Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia Open
Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T cell acute lymphoblastic leukemia (T-ALL), making the Notch signaling pathway a promising therapeutic target for personalized medicine. Yet, a major …
View article: Proteome adaptations of the organohalide-respiring Desulfitobacterium hafniense strain DCB-2 to various energy metabolisms
Proteome adaptations of the organohalide-respiring Desulfitobacterium hafniense strain DCB-2 to various energy metabolisms Open
Introduction Desulfitobacterium hafniense was isolated for its ability to use organohalogens as terminal electron acceptors via organohalide respiration (OHR). In contrast to obligate OHR bacteria, Desulfitobacterium spp. show a highly ver…
View article: Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia Open
Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T cell acute lymphoblastic leukemia (T-ALL), making the Notch signaling pathway a promising therapeutic target for personalized medicine. Yet, a major …
View article: Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization Open
View article: Correction to: Regulation of Src tumor activity by its N-terminal intrinsically disordered region
Correction to: Regulation of Src tumor activity by its N-terminal intrinsically disordered region Open
View article: Function-guided proximity mapping unveils electrophilic-metabolite sensing by proteins not present in their canonical locales
Function-guided proximity mapping unveils electrophilic-metabolite sensing by proteins not present in their canonical locales Open
Significance The cell is a hive of information flow in which metabolite signals and proteins translocate across subcompartments. Peering into this submicroscopic world is hugely challenging. Using a strategy termed Localis-rex, we identify…
View article: Regulation of Src tumor activity by its N-terminal intrinsically disordered region
Regulation of Src tumor activity by its N-terminal intrinsically disordered region Open
View article: Hypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Pharmaceutical Ingredients of Homologous Standardized Transplant Products in Tendon Regenerative Medicine
Hypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Pharmaceutical Ingredients of Homologous Standardized Transplant Products in Tendon Regenerative Medicine Open
Human fetal progenitor tenocytes (hFPT) produced in defined cell bank systems have recently been characterized and qualified as potential therapeutic cell sources in tendon regenerative medicine. In view of further developing the manufactu…
View article: Regulation of Src tumor activity by its N-terminal intrinsically disordered region
Regulation of Src tumor activity by its N-terminal intrinsically disordered region Open
The membrane anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src regulation relies on crystallography, which revealed intramolecular interactions to control a…
View article: Lysozyme-Induced Transcriptional Regulation of TNF-α Pathway Genes in Cells of the Monocyte Lineage
Lysozyme-Induced Transcriptional Regulation of TNF-α Pathway Genes in Cells of the Monocyte Lineage Open
Lysozyme is one of the most important anti-bacterial effectors in the innate immune system of animals. Besides its direct antibacterial enzymatic activity, lysozyme displays other biological properties, pointing toward a significant anti-i…
View article: Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA
Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA Open
Plasmodium falciparum is the main cause of disease and death from malaria. P. falciparum virulence resides in the ability of infected erythrocytes (IEs) to sequester in various tissues through the interaction between members of the polymor…
View article: Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles
Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles Open
Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features and functions are poorly characterized. Here, we report methodolog…
View article: Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients
Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients Open
Liquid biopsies allow monitoring of cancer progression and detection of relapse, but reliable biomarkers in melanoma are lacking. Because secreted factors preferentially drain to lymphatic vessels before dilution in the blood, we hypothesi…
View article: Analysis of the S. pombe Meiotic Proteome Reveals a Switch from Anabolic to Catabolic Processes and Extensive Post-transcriptional Regulation
Analysis of the S. pombe Meiotic Proteome Reveals a Switch from Anabolic to Catabolic Processes and Extensive Post-transcriptional Regulation Open
View article: The making of a Lewy body: the role of alpha-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions.
The making of a Lewy body: the role of alpha-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions. Open
Although converging evidence point to alpha-synuclein (a-syn) aggregation and Lewy body (LB) formation as central events in Parkinson's disease (PD), the molecular mechanisms that regulate these processes and their role in disease pathogen…
View article: The Membrane-Bound C Subunit of Reductive Dehalogenases: Topology Analysis and Reconstitution of the FMN-Binding Domain of PceC
The Membrane-Bound C Subunit of Reductive Dehalogenases: Topology Analysis and Reconstitution of the FMN-Binding Domain of PceC Open
Organohalide respiration (OHR) is the energy metabolism of anaerobic bacteria able to use halogenated organic compounds as terminal electron acceptors. While the terminal enzymes in OHR, so-called reductive dehalogenases, are well-characte…
View article: Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis
Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis Open
Centrioles are evolutionarily conserved macromolecular structures that are fundamental to form cilia, flagella, and centrosomes. Centrioles are 9-fold symmetrical microtubule-based cylindrical barrels comprising three regions that can be c…
View article: Differential signaling networks of Bcr–Abl p210 and p190 kinases in leukemia cells defined by functional proteomics
Differential signaling networks of Bcr–Abl p210 and p190 kinases in leukemia cells defined by functional proteomics Open
View article: Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity
Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity Open
The target autoantigens in several organ-specific autoimmune diseases, including type 1 diabetes (T1D), are intracellular membrane proteins, whose initial encounter with the immune system is poorly understood. Here we propose a new model f…
View article: Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1
Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1 Open
Casein kinase 1 (CK1) is a pleiotropic protein kinase implicated in several fundamental processes of eukaryotic cell biology. Plasmodium falciparum encodes a single CK1 isoform, PfCK1, that is expressed at all stages of the parasite's life…