Romain Paccoud
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View article: Hypothalamic Glucose Hypersensitivity-Induced Insulin Secretion in the Obese Zücker Rat Is Reversed by Central Ghrelin Treatment
Hypothalamic Glucose Hypersensitivity-Induced Insulin Secretion in the Obese Zücker Rat Is Reversed by Central Ghrelin Treatment Open
Aims: Part of hypothalamic (mediobasal hypothalamus [MBH]) neurons detect changes in blood glucose levels that in turn coordinate the vagal control of insulin secretion. This control cascade requires the production of mitocho…
View article: The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? Open
The SH2 containing protein tyrosine phosphatase 2(SHP2) plays essential roles in fundamental signaling pathways, conferring on it versatile physiological functions during development and in homeostasis maintenance, and leading to major pat…
View article: Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor
Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor Open
Dysregulations of lipid metabolism in the liver may trigger steatosis progression, leading to potentially severe clinical consequences such as nonalcoholic fatty liver diseases (NAFLDs). Molecular mechanisms underlying liver lipogenesis ar…
View article: Macrophage‐derived HMGB1 is dispensable for tissue fibrogenesis
Macrophage‐derived HMGB1 is dispensable for tissue fibrogenesis Open
Alarmins and damage‐associated molecular patterns (DAMPs) are powerful inflammatory mediators, capable of initiating and maintaining sterile inflammation during acute or chronic tissue injury. Recent evidence suggests that alarmins/DAMPs m…
View article: Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing
Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing Open
A hypothalamic alteration of DRP1-induced fission and mROS signaling in response to glucose was observed in HGS-induced IS of rats exposed to a 3 week HFHS diet. Early hypothalamic modifications of the neuronal activity could participate i…
View article: Impact de la protéine SHP2 associé au syndrome de Noonan sur le métabolisme glucidique
Impact de la protéine SHP2 associé au syndrome de Noonan sur le métabolisme glucidique Open
Le diabète de type 2 (DT2) est une maladie qui affecte de plus en plus de personnes à travers le monde et comporte plusieurs complications. Les moyens thérapeutiques actuels sont assez limités, car même s'ils sont efficaces, ils sont assoc…
View article: The RASopathy Family: Consequences of Germline Activation of the RAS/MAPK Pathway
The RASopathy Family: Consequences of Germline Activation of the RAS/MAPK Pathway Open
Noonan syndrome [NS; Mendelian Inheritance in Men (MIM) #163950] and related syndromes [Noonan syndrome with multiple lentigines (formerly called LEOPARD syndrome; MIM #151100), Noonan-like syndrome with loose anagen hair (MIM #607721), Co…