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View article: Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease
Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease Open
Objective Impaired hepatic expression of protein tyrosine phosphatase delta ( PTPRD ) is associated with increased STAT3 transcriptional activity and reduced survival from hepatocellular carcinoma in patients with chronic hepatitis C virus…
View article: G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes
G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes Open
Phase separation regulates fundamental processes in gene expression and is mediated by the local concentration of proteins and nucleic acids, as well as nucleic acid secondary structures such as G-quadruplexes (G4s). These structures play …
View article: Loss of <i>Pla2r1</i> decreases cellular senescence and age‐related alterations caused by aging and Western diets
Loss of <i>Pla2r1</i> decreases cellular senescence and age‐related alterations caused by aging and Western diets Open
Cellular senescence is induced by many stresses including telomere shortening, DNA damage, oxidative, or metabolic stresses. Senescent cells are stably cell cycle arrested and they secrete many factors including cytokines and chemokines. A…
View article: Axon guidance molecules in liver pathology: Journeys on a damaged passport
Axon guidance molecules in liver pathology: Journeys on a damaged passport Open
Background and Aims The liver is an innervated organ that develops a variety of chronic liver disease (CLD). Axon guidance cues (AGCs), of which ephrins, netrins, semaphorins and slits are the main representative, are secreted or membrane‐…
View article: Supplementary Table S2 from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth
Supplementary Table S2 from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth Open
Supplementary Table S2 from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth
View article: Supplementary Table S2 from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth
Supplementary Table S2 from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth Open
Supplementary Table S2 from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth
View article: Supplementary Table S1 from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth
Supplementary Table S1 from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth Open
Supplementary Table S1 from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth
View article: Data from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth
Data from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth Open
The mammalian target of rapamycin (mTOR) pathway, a major regulator of translation, is frequently activated in hepatocellular carcinomas. We investigated the effects of mTOR activation in the human HepaRG cells, which possess potent hepato…
View article: Data from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth
Data from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth Open
The mammalian target of rapamycin (mTOR) pathway, a major regulator of translation, is frequently activated in hepatocellular carcinomas. We investigated the effects of mTOR activation in the human HepaRG cells, which possess potent hepato…
View article: Supplementary Table S1 from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth
Supplementary Table S1 from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth Open
Supplementary Table S1 from Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth
View article: Hepatocellular carcinoma hosts immature neurons and cholinergic tumors that correlate with adverse molecular features and outcomes
Hepatocellular carcinoma hosts immature neurons and cholinergic tumors that correlate with adverse molecular features and outcomes Open
Background & aims The unexplained interpatient variation in hepatocellular carcinoma (HCC) remains a major challenge. We aimed at addressing the under-explored association between the disease and the hepatic autonomic nervous system (ANS).…
View article: Hepatic inflammation elicits production of proinflammatory netrin‐1 through exclusive activation of translation
Hepatic inflammation elicits production of proinflammatory netrin‐1 through exclusive activation of translation Open
Background and Aims Netrin‐1 displays protumoral properties, though the pathological contexts and processes involved in its induction remain understudied. The liver is a major model of inflammation‐associated cancer development, leading to…
View article: Copper Isotope Evidence of Oxidative Stress–Induced Hepatic Breakdown and the Transition to Hepatocellular Carcinoma
Copper Isotope Evidence of Oxidative Stress–Induced Hepatic Breakdown and the Transition to Hepatocellular Carcinoma Open
The clear bimodality does not correspond to a progressive shift of the δ65Cu values but to a replacement of one population by another. This bimodality sheds light on the persisting difficulties epitomized by α-fetoprotein in finding high-s…
View article: Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p
Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p Open
Immune-mediated induction of cytidine deaminase APOBEC3B is transcriptionally regulated by NF-κB signalling and post-transcriptionally downregulated by hsa-miR-138-5p expression, leading to cccDNA decay. Timely controlled APOBEC3B-mediated…
View article: Hepatic Stellate Cell Senescence in Liver Tumorigenesis
Hepatic Stellate Cell Senescence in Liver Tumorigenesis Open
International audience
View article: Cluster of differentiation 44 promotes osteosarcoma progression in mice lacking the tumor suppressor Merlin
Cluster of differentiation 44 promotes osteosarcoma progression in mice lacking the tumor suppressor Merlin Open
Merlin is a versatile tumor suppressor protein encoded by the NF2 gene. Several lines of evidence suggest that Merlin exerts its tumor suppressor activity, at least in part, by forming an inhibitory complex with cluster of differentiation …
View article: The Potential Implication of the Autonomic Nervous System in Hepatocellular Carcinoma
The Potential Implication of the Autonomic Nervous System in Hepatocellular Carcinoma Open
International audience
View article: HCV levels correlate with the expression of Netrin-1 in the liver biopsies of HCV-infected patients.
HCV levels correlate with the expression of Netrin-1 in the liver biopsies of HCV-infected patients. Open
A. HCV-positive samples exhibit the highest levels of Netrin-1 mRNA of all the chronic liver disease biopsies. The levels of Netrin-1 mRNA were quantified by RT-qPCR. Statistical significance was determined using the Mann-Whitney test. B. …
View article: Epidermal Growth Factor Receptor-Dependent Mutual Amplification between Netrin-1 and the Hepatitis C Virus
Epidermal Growth Factor Receptor-Dependent Mutual Amplification between Netrin-1 and the Hepatitis C Virus Open
Hepatitis C virus (HCV) is an oncogenic virus associated with the onset of hepatocellular carcinoma (HCC). The present study investigated the possible link between HCV infection and Netrin-1, a ligand for dependence receptors that sustains…