Explanipedia

Chemsex, drugs and consequences: A short review Open

Romain Pelletier, Thomas Gicquel · 2025

No increase of targetable oncogenic fusions prevalence in non-colorectal mismatch repair-deficient tumors Open

Loëtitia Favre, Christina Nguyen, Julien Caldéraro, Romain Pelletier, Yaëlle Bellahsen , et al. · 2025

Mismatch repair deficiency is a well-described mechanism of carcinogenesis, which can be identified by microsatellite instability (MSI). In colorectal cancers (CRC), cases with hypermethylation of the MLH1 promoter with wild-type (WT) BRAF…

Studying APAP metabolism in a cohort of intoxicated patients using HRMS-based profiling: Detection of catechol and delayed thiomethyl metabolites Open

Thomas Gicquel, Romain Pelletier, Eva Gorrochategui, Margaux Heurté, Diane Le Bouëdec , et al. · 2025

Identifying metabolites of new psychoactive substances using in silico prediction tools Open

Romain Pelletier, Dina Nahle, M. G. Sarr, Alexis Bourdais, Isabelle Morel , et al. · 2025

Cathinone metabolism and biliary excretion in an ex-vivo pig liver model: Example of 4-Cl-PVP and eutylone Open

Romain Pelletier, Brendan Le Daré, Thomas Kerforne, Nicolas Patou Parvedy, Florian Lemaitre , et al. · 2025

The pig liver model perfused ex vivo using an NMP represent a promising model in pharmaco-toxicology, particularly for toxicokinetic investigations of cathinones. This model may be of interest in the absence of authentic cases of cathinone…

Role of CYP2D6 polymorphisms in tramadol metabolism in a context of co-medications and overweight Open

Pierre‐Jean Ferron, Romain Pelletier, Julie Massart, Céline Narjoz, Vinh-Hoang-Lan Julie Tran , et al. · 2024

Very few quantitative data exist on tramadol metabolites, which hampers our understanding of their role in efficacy and safety of tramadol. We aimed to provide quantitative data on tramadol and its 5 main metabolites in a patient cohort an…

ICE volume 45 issue 5 Cover and Front matter Open

Stephanie Sweitzer, Emily Sickbert-Bennett, Jessica Seidelman, Deverick J. Anderson, Moe R. Lim , et al. · 2024

The impact of environmental cleaning protocol featuring PX-UV in reducing the incidence of multidrug-resistant gram-negative

In vitro assessment of isopropanol leakage from antiseptic barrier caps into commonly used needleless connectors Open

Camille Boissière, Astrid Bacle, Romain Pelletier, Diane Le Bouëdec, Thomas Gicquel , et al. · 2024

Background: Needleless connectors (NCs) can be disinfected using antiseptic barrier caps (ABCs) to reduce the risk of catheter-related bloodstream infections. However, recent evidence suggests that isopropanol can leak from the ABC into th…

Severe 25E-NBOH intoxication associated with MDPHP intake: a case report, metabolism study, and literature review Open

Romain Pelletier, Thomas Gicquel, Julien Carvelli, P Baláz, Anne‐Laure Pélissier‐Alicot , et al. · 2023

Pediatric cannabis intoxication in France and Belgium: A 3-year retrospective study Open

Nadia Arbouche, Laurie Gheddar, Joris Guyon, Alice Matheux, Jenny Becam , et al. · 2023

Arylcyclohexylamine Derivatives: Pharmacokinetic, Pharmacodynamic, Clinical and Forensic Aspects Open

Romain Pelletier, Brendan Le Daré, Diane Le Bouëdec, Angéline Kernalléguen, Pierre‐Jean Ferron , et al. · 2022

Since the 2000s, an increasing number of new psychoactive substances (NPS) have appeared on the drug market. Arylcyclohexylamine (ACH) compounds such as ketamine, phencyclidine and eticyclidine derivatives are of particular concern, given …

A Transversal Approach Combining In Silico, In Vitro and In Vivo Models to Describe the Metabolism of the Receptor Interacting Protein 1 Kinase Inhibitor Sibiriline Open

Romain Pelletier, Thomas Gicquel, Mélanie Simoes Eugénio, Pierre‐Jean Ferron, Isabelle Morel , et al. · 2022

Sibiriline is a novel drug inhibiting receptor-interacting protein 1 kinase (RIPK1) and necroptosis, a regulated form of cell death involved in several disease models. In this study, we aimed to investigate the metabolic fate of sibiriline…

Magic truffle intoxication: A case report Open

Brendan Le Daré, Romain Pelletier, Aurélien Couette, Isabelle Morel, Thomas Gicquel · 2022

Unusual forms of hallucinogenic mushrooms are emerging, which may delay diagnosis and compromise optimal management. Here, we discuss clinical and biological findings in a case of “magic mushroom” intoxication in a 20-year-old man who was …

Molecular Networking for Drug Toxicities Studies: The Case of Hydroxychloroquine in COVID-19 Patients Open

Pierre‐Jean Ferron, Brendan Le Daré, Julie Bronsard, Clara Steichen, Elodie Babina , et al. · 2021

Using drugs to treat COVID-19 symptoms may induce adverse effects and modify patient outcomes. These adverse events may be further aggravated in obese patients, who often present different illnesses such as metabolic-associated fatty liver…

New psychoactive substance cocktail in an intensive care intoxication case elucidated by molecular networking Open

Romain Pelletier, Brendan Le Daré, Loic Grandin, Aurélien Couette, Pierre‐Jean Ferron , et al. · 2021

This case illustrates the interest of MN to (i) perform sample-to-sample comparison, (ii) target quantification methods, and (iii) allow proper management to confirm the relevance of the treatment.

Fatal intoxication related to two new arylcyclohexylamine derivatives (2F-DCK and 3-MeO-PCE) Open

Thomas Gicquel, Camille Richeval, Vadim Mesli, Alexandr Gish, Florian Hakim , et al. · 2021

Histoire de la kétamine : une molécule ancienne qui a toujours la cote Open

Brendan Le Daré, Romain Pelletier, Isabelle Morel, Thomas Gicquel · 2021

High Prevalence of Fungal Infections in Mechanically Ventilated COVID-19 Patients in the ICU: The French Multicenter MYCOVID Study Open

Jean‐Pierre Gangneux, Éric Dannaoui, Arnaud Fekkar, Charles Edouard Luyt, Françoise Botterel , et al. · 2021

Is the COVID-19 Pandemic a Good Time to Include Aspergillus Molecular Detection to Categorize Aspergillosis in ICU Patients? A Monocentric Experience Open

Jean‐Pierre Gangneux, Florian Reizine, Hélène Guegan, Kieran Pinceaux, Pierre Le Balc’h , et al. · 2020

(1) Background: The diagnosis of invasive aspergillosis (IA) in an intensive care unit (ICU) remains a challenge and the COVID-19 epidemic makes it even harder. Here, we evaluated Aspergillus PCR input to help classifying IA in SARS-CoV-2-…

Early care of N-acetyl glutamate synthase (NAGS) deficiency in three infants from an inbred family Open

Katell Peoc’h, Léna Damaj, Romain Pelletier, Charles R. Lefèvre, Christèle Dubourg , et al. · 2020

N-acetyl glutamate synthase (NAGS) deficiency is the rarest urea cycle defect presenting as neonatal onset life-threatening hyperammonemia. We report here a family history of severe NAGS deficiency: after the index-case with severe …

Evaluation of the Idylla system to detect the EGFR mutation using extracted DNA Open

Claire Bocciarelli, Justine V. Cohen, Romain Pelletier, Jeanne Tran Van Nhieu, Jonathan Derman , et al. · 2019

INTEGRATIVE ANALYSIS OF FEATURES ASSOCIATED WITH TET2, IDH2, DNMT3A, AND RHOA MUTATIONS IN ANGIOIMMUNOBLASTIC T CELL LYMPHOMA: A LYSA STUDY Open

François Lemonnier, Violaine Safar, Anne‐Ségolène Cottereau, Virginie Fataccioli, I. Chaillol , et al. · 2017

Introduction: Angioimmunoblastic T cell lymphoma (AITL) is the most frequent non-cutaneous peripheral T-cell lymphoma in Western Europe and is associated with a poor prognosis. Mutations in the epigenetic regulators TET2, IDH2, and DNMT3A,…

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