Romain Yvinec
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View article: Rapid cell turnover to model adipocyte size distribution
Rapid cell turnover to model adipocyte size distribution Open
White adipose tissue, composed of adipocyte cells, primarily stores energy as lipid droplets. The size of adipocytes varies significantly within the tissue according to the amount of stored lipids. A striking observation is that the adipoc…
View article: Computational Prediction of Intracellular Signaling Behavior via Machine Learning
Computational Prediction of Intracellular Signaling Behavior via Machine Learning Open
International audience
View article: Two-State Stochastic Model of In Vivo Observations of Transcriptional Bursts
Two-State Stochastic Model of In Vivo Observations of Transcriptional Bursts Open
In vivo measurements of gene expression in single cells show behavior that has been interpreted as stochastic bursts of transcription. In one case, these data have been interpreted as random ON–OFF transitions of the gene, but there is no …
View article: The insertion of Neomycin cassette impairs maternal and social behaviors in Arc/Arg3.1 knock-out mice
The insertion of Neomycin cassette impairs maternal and social behaviors in Arc/Arg3.1 knock-out mice Open
The Neomycin resistance cassette (Neo+) is commonly inserted in the genome of mice to generate knock-out (KO) models. The effect of gene deletion on social behaviors in mice is controversial between studies using different Neo+ and Neo-mou…
View article: Hormone-regulated dynamics of mRNA distribution on ribosomes in Sertoli cells
Hormone-regulated dynamics of mRNA distribution on ribosomes in Sertoli cells Open
The effects of hormone stimulation on the cell translational profile remain poorly understood. Here, using polysome profiling combined to RNA sequencing, we analyzed the translational response to follicle-stimulating hormone (FSH) of prima…
View article: Targeting selectively oxytocin receptor signalling efficiently improves social interaction in Fmr1 KO mice
Targeting selectively oxytocin receptor signalling efficiently improves social interaction in Fmr1 KO mice Open
Background and Purpose: No drugs targeting the core social features of autism spectrum disorder (ASD) have been approved. Although clinical trials with oxytocin (OT) and vasopressin (AVP) have yielded mixed results, targeting their recepto…
View article: Well-posedness and bifurcation analysis of a size-structured population model: Application to female gametes dynamics
Well-posedness and bifurcation analysis of a size-structured population model: Application to female gametes dynamics Open
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View article: Time scale separation in life-long ovarian follicles population dynamics model
Time scale separation in life-long ovarian follicles population dynamics model Open
International audience
View article: Mathematical modeling of adipocyte size distributions: Identifiability and parameter estimation from rat data
Mathematical modeling of adipocyte size distributions: Identifiability and parameter estimation from rat data Open
View article: A Lifshitz–Slyozov type model for adipocyte size dynamics: limit from Becker–Döring system and numerical simulation
A Lifshitz–Slyozov type model for adipocyte size dynamics: limit from Becker–Döring system and numerical simulation Open
View article: Modeling compartmentalization within intracellular signaling pathway
Modeling compartmentalization within intracellular signaling pathway Open
We present a novel approach to modeling receptor-activated signaling pathways that take into account the compartmentalization of receptors and their effectors, both on the cell surface and in dynamic intracellular vesicles called endosomes…
View article: Some Remarks About the Well-Posedness of Lifshitz–Slyozov’s Equations with Nucleation Kinetics
Some Remarks About the Well-Posedness of Lifshitz–Slyozov’s Equations with Nucleation Kinetics Open
View article: Long-time asymptotics of the Lifshitz–Slyozov equation with nucleation
Long-time asymptotics of the Lifshitz–Slyozov equation with nucleation Open
We consider the Lifshitz–Slyozov model with inflow boundary conditions of nucleation type. We show that for a collection of representative rate functions the size distributions approach degenerate states concentrated at zero size for suffi…
View article: Comparative dynamics of female germ cell populations : insight from imaging and multiscale modeling
Comparative dynamics of female germ cell populations : insight from imaging and multiscale modeling Open
International audience
View article: Modeling compartmentalization within intracellular signaling pathway
Modeling compartmentalization within intracellular signaling pathway Open
We present a new modeling approach for G protein coupled receptors signaling systems, that take into account the compartmentalization of receptors and their effectors, both at plasma membrane and in dynamic intra-cellular vesicles called e…
View article: Long-time asymptotic of the Lifshitz-Slyozov equation with nucleation
Long-time asymptotic of the Lifshitz-Slyozov equation with nucleation Open
We consider the Lifshitz-Slyozov model with inflow boundary conditions of nucleation type. We show that for a collection of representative rate functions the size distributions approach degenerate states concentrated at zero size for suffi…
View article: A Lifschitz-Slyozov type model for adipocyte size dynamics : limit from Becker-Döring system and numerical simulation
A Lifschitz-Slyozov type model for adipocyte size dynamics : limit from Becker-Döring system and numerical simulation Open
View article: Stochastic Becker-Döring model: Large population and large time results for phase transition phenomena
Stochastic Becker-Döring model: Large population and large time results for phase transition phenomena Open
International audience
View article: An overview of deep learning applications in precocious puberty and thyroid dysfunction
An overview of deep learning applications in precocious puberty and thyroid dysfunction Open
In the last decade, deep learning methods have garnered a great deal of attention in endocrinology research. In this article, we provide a summary of current deep learning applications in endocrine disorders caused by either precocious ons…
View article: Averaging of a Stochastic Slow-Fast Model for Population Dynamics: Application to the Development of Ovarian Follicles
Averaging of a Stochastic Slow-Fast Model for Population Dynamics: Application to the Development of Ovarian Follicles Open
International audience
View article: Dynamical modeling of reaction networks. Application to biased signaling
Dynamical modeling of reaction networks. Application to biased signaling Open
International audience
View article: Modeling (some aspects of ) the female reproductive system
Modeling (some aspects of ) the female reproductive system Open
International audience
View article: Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor
Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor Open
Follicle-stimulating hormone receptor (FSHR) plays a key role in reproduction through the activation of multiple signaling pathways. Low molecular weight (LMW) ligands composed of biased agonist properties are highly valuable tools to deci…
View article: Stochastic nonlinear model for somatic cell population dynamics during ovarian follicle activation
Stochastic nonlinear model for somatic cell population dynamics during ovarian follicle activation Open
View article: Quasi-stationary distribution and metastability for the stochastic Becker-Döring model
Quasi-stationary distribution and metastability for the stochastic Becker-Döring model Open
We study a stochastic version of the classical Becker-Döring model, a well-known kinetic model for cluster formation that predicts the existence of a long-lived metastable state before a thermodynamically unfavorable nucleation occurs, lea…
View article: Some contributions to the study of population dynamics models and coagulation-fragmentation
Some contributions to the study of population dynamics models and coagulation-fragmentation Open
View article: Modeling GPCR-induced biased signalingTowards a system biology definition of drugs selectivity
Modeling GPCR-induced biased signalingTowards a system biology definition of drugs selectivity Open
International audience
View article: Dynamical modeling of reaction networks and biased signaling. Mathematics of system biology
Dynamical modeling of reaction networks and biased signaling. Mathematics of system biology Open
International audience
View article: Dynamical modeling of reaction networksMathematics of system biology
Dynamical modeling of reaction networksMathematics of system biology Open
International audience
View article: Quasi-stationary distribution and metastability for the stochastic\n Becker-D\\"oring model
Quasi-stationary distribution and metastability for the stochastic\n Becker-D\\"oring model Open
We study a stochastic version of the classical Becker-D\\"oring model, a\nwell-known kinetic model for cluster formation that predicts the existence of a\nlong-lived metastable state before a thermodynamically unfavorable nucleation\noccur…