Roman Ashauer
YOU?
Author Swipe
View article: Evaluating the impact of experimental duration on toxicokinetic parameters and bioaccumulation factors in earthworm (<i>Eisenia fetida</i>) studies
Evaluating the impact of experimental duration on toxicokinetic parameters and bioaccumulation factors in earthworm (<i>Eisenia fetida</i>) studies Open
Earthworms contribute to soil health and nutrient cycling and serve as a crucial food source for higher trophic organisms. The Organisation for Economic Co-operation and Development (OECD) 317 bioaccumulation test investigates the potentia…
View article: Comparison of absorption and excretion of test compounds in sucking versus chewing pests
Comparison of absorption and excretion of test compounds in sucking versus chewing pests Open
A critical understanding of how pests interact with active ingredients is essential for the development of new insect control solutions to maintain crop quality and quantity by reducing insect damage. Absorption of insecticides into insect…
View article: TRTBee: a standalone calculator for time-reinforced toxicity according to European Food Safety Authority honeybee guidelines
TRTBee: a standalone calculator for time-reinforced toxicity according to European Food Safety Authority honeybee guidelines Open
The revised European Food Safety Authority (EFSA) guidance document for the risk assessment of plant protection products on honeybees requires an assessment of time-reinforced toxicity (TRT) using toxicokinetic-toxicodynamic modeling. Alth…
View article: Critical biotransformation half-lives of chemicals in air-breathing wildlife to assess food-chain bioaccumulation and biomagnification
Critical biotransformation half-lives of chemicals in air-breathing wildlife to assess food-chain bioaccumulation and biomagnification Open
This study reveals species-specific variations, across chemical partition space, in the required critical biotransformation half-life to avoid biomagnification and presents a weight-of-evidence approach with a focus on biotransformation.
View article: Environmental Risk Assessment of Time-Variable Toxicant Exposure with Toxicokinetic–Toxicodynamic Modeling of Sublethal Endpoints and Moving Time Windows: A Case Study with <i>Ceriodaphnia dubia</i>
Environmental Risk Assessment of Time-Variable Toxicant Exposure with Toxicokinetic–Toxicodynamic Modeling of Sublethal Endpoints and Moving Time Windows: A Case Study with <i>Ceriodaphnia dubia</i> Open
Toxicokinetic–toxicodynamic (TKTD) modeling has received increasing attention in terms of the regulatory environmental risk assessment of chemicals. This type of mechanistic model can integrate all available data from individual-level bioa…
View article: A User-Friendly Kinetic Model Incorporating Regression Models for Estimating Pesticide Accumulation in Diverse Earthworm Species Across Varied Soils
A User-Friendly Kinetic Model Incorporating Regression Models for Estimating Pesticide Accumulation in Diverse Earthworm Species Across Varied Soils Open
Existing models for estimating pesticide bioconcentration in earthworms exhibit limited applicability across different chemicals, soils and species which restricts their potential as an alternative, intermediate tier for risk assessment. W…
View article: Correspondence on “Mortality Pattern of <i>Poecilus cupreus</i> Beetles after Repeated Topical Exposure to Insecticide─Stochastic Death or Individual Tolerance?”
Correspondence on “Mortality Pattern of <i>Poecilus cupreus</i> Beetles after Repeated Topical Exposure to Insecticide─Stochastic Death or Individual Tolerance?” Open
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVCorrespondence/Rebut...Correspondence/RebuttalNEXTCorrespondence on "Mortality Pattern of Poecilus cupreus Beetles after Repeated Topical Exposure to Insecticide─Stochastic Death or Individual Toler…
View article: Evaluation of models to estimate the bioaccumulation of organic chemicals in earthworms
Evaluation of models to estimate the bioaccumulation of organic chemicals in earthworms Open
Modelling approaches to estimate the bioaccumulation of organic chemicals by earthworms are important for improving the realism in risk assessment of chemicals. However, the applicability of existing models is uncertain, partly due to the …
View article: Earthworm lipid content and size help account for differences in pesticide bioconcentration between species
Earthworm lipid content and size help account for differences in pesticide bioconcentration between species Open
The uptake and elimination kinetics of pesticides from soil to earthworms are important in characterising the risk of pesticides to soil organisms and the risk from secondary poisoning. However, the understanding of the relative importance…
View article: Characterization of patterns and variability in the dynamics of outdoor aquatic mesocosms: exploring the capabilities and challenges in data supporting aquatic system models
Characterization of patterns and variability in the dynamics of outdoor aquatic mesocosms: exploring the capabilities and challenges in data supporting aquatic system models Open
Aquatic mesocosms are complex test systems used within regulatory risk assessment of plant protection products. These model ecosystems allow researchers to capture interactions of multiple species under realistic environmental conditions. …
View article: A Framework for Algae Modeling in Regulatory Risk Assessment
A Framework for Algae Modeling in Regulatory Risk Assessment Open
The use of toxicokinetic–toxicodynamic (TKTD) modeling in regulatory risk assessment of plant protection products is increasingly popular, especially since the 2018 European Food Safety Authority (EFSA) opinion on TKTD modeling announced t…
View article: Characterization of patterns and variability in the dynamics of outdoor aquatic mesocosms: exploring the capabilities and challenges in data supporting aquatic system models
Characterization of patterns and variability in the dynamics of outdoor aquatic mesocosms: exploring the capabilities and challenges in data supporting aquatic system models Open
Aquatic mesocosms are complex test systems used within regulatory risk assessment of plant protection products. These model ecosystems allow to capture interactions of multiple species under environmental conditions. They enable assessment…
View article: Earthworm Lipid Content and Size Help Account for Differences in Pesticide Bioconcentration between Species
Earthworm Lipid Content and Size Help Account for Differences in Pesticide Bioconcentration between Species Open
View article: Modelling the effects of the pyrethroid insecticide cypermethrin on the life cycle of the soil dwelling annelid Enchytraeus crypticus, an original experimental design to calibrate a DEB-TKTD model
Modelling the effects of the pyrethroid insecticide cypermethrin on the life cycle of the soil dwelling annelid Enchytraeus crypticus, an original experimental design to calibrate a DEB-TKTD model Open
The Dynamic Energy Budget theory (DEB) enables ecotoxicologists to model the effects of chemical stressors on organism life cycles through the coupling of toxicokinetic-toxicodynamic (TK-TD) models. While good progress has been made in the…
View article: A site-specific indicator of nitrogen loads into surface waters from conventional and conservation agriculture practices: Bayesian network model
A site-specific indicator of nitrogen loads into surface waters from conventional and conservation agriculture practices: Bayesian network model Open
View article: How to analyse and account for interactions in mixture toxicity with toxicokinetic-toxicodynamic models
How to analyse and account for interactions in mixture toxicity with toxicokinetic-toxicodynamic models Open
The assessment of chemical mixture toxicity is one of the major challenges in ecotoxicology. Chemicals can interact, leading to more or less effects than expected, commonly named synergism and antagonism respectively. The classic ad hoc ap…
View article: Interactive effects of multiple stressors vary with consumer interactions, stressor dynamics and magnitude
Interactive effects of multiple stressors vary with consumer interactions, stressor dynamics and magnitude Open
Predicting the impacts of multiple stressors is important for informing ecosystem management but is impeded by a lack of a general framework for predicting whether stressors interact synergistically, additively or antagonistically. Here, w…
View article: Fish Species Sensitivity Ranking Depends on Pesticide Exposure Profiles
Fish Species Sensitivity Ranking Depends on Pesticide Exposure Profiles Open
In the regulatory environmental risk assessment of plant protection products, the exposure tested in standard toxicity tests assumes simple exposure dynamics, such as constant exposure at the first stage of testing. However, environmental …
View article: The application and limitations of exposure multiplication factors in sublethal effect modelling
The application and limitations of exposure multiplication factors in sublethal effect modelling Open
Thanks to growing interest and research in the field, toxicokinetic–toxicodynamic (TKTD) models are close to realising their potential in environmental risk assessment (ERA) of chemicals such as plant protection products. A fundamental app…
View article: Modelling the effects of variability in feeding rate on growth – a vital step for DEB-TKTD modelling
Modelling the effects of variability in feeding rate on growth – a vital step for DEB-TKTD modelling Open
View article: Dataset for: Factors affecting the growth of Pseudokirchneriella subcapitata in single-species tests: lessons for the experimental design and the reproducibility of a multi-trophic laboratory microcosm
Dataset for: Factors affecting the growth of Pseudokirchneriella subcapitata in single-species tests: lessons for the experimental design and the reproducibility of a multi-trophic laboratory microcosm Open
The need for an integrated risk assessment at an ecologically relevant scale (e.g. at the population/community levels) has been acknowledged. Multi-species systems with increased ecological complexity, however, are difficult if not impossi…
View article: Interactive effects of multiple stressors vary with consumer interactions, stressor dynamics and magnitude
Interactive effects of multiple stressors vary with consumer interactions, stressor dynamics and magnitude Open
Predicting the impacts of multiple stressors is important for informing ecosystem management, but is impeded by a lack of a general framework for predicting whether stressors interact synergistically, additively, or antagonistically. Here …
View article: Considerations for using reproduction data in toxicokinetic–toxicodynamic modeling
Considerations for using reproduction data in toxicokinetic–toxicodynamic modeling Open
Toxicokinetic–toxicodynamic (TKTD) modeling is essential to make sense of the time dependence of toxic effects, and to interpret and predict consequences of time-varying exposure. These advantages have been recognized in the regulatory are…
View article: Considerations for using reproduction data in toxicokinetic-toxicodynamic modelling
Considerations for using reproduction data in toxicokinetic-toxicodynamic modelling Open
Toxicokinetic-toxicodynamic (TKTD) modelling is essential to make sense of the time dependence of toxic effects, and to interpret and predict consequences of time-varying exposure. These advantages have been recognised in the regulatory ar…
View article: Predicting Mixture Effects over Time with Toxicokinetic–Toxicodynamic Models (GUTS): Assumptions, Experimental Testing, and Predictive Power
Predicting Mixture Effects over Time with Toxicokinetic–Toxicodynamic Models (GUTS): Assumptions, Experimental Testing, and Predictive Power Open
Current methods to assess the impact of chemical mixtures on organisms ignore the temporal dimension. The General Unified Threshold model for Survival (GUTS) provides a framework for deriving toxicokinetic-toxicodynamic (TKTD) models, whic…
View article: Mechanistic Effect Modeling of Earthworms in the Context of Pesticide Risk Assessment: Synthesis of the FORESEE Workshop
Mechanistic Effect Modeling of Earthworms in the Context of Pesticide Risk Assessment: Synthesis of the FORESEE Workshop Open
Earthworms are important ecosystem engineers, and assessment of the risk of plant protection products toward them is part of the European environmental risk assessment (ERA). In the current ERA scheme, exposure and effects are represented …
View article: Bioenergetics modelling to analyse and predict the joint effects of multiple stressors: Meta-analysis and model corroboration
Bioenergetics modelling to analyse and predict the joint effects of multiple stressors: Meta-analysis and model corroboration Open
View article: Effect Modeling Quantifies the Difference Between the Toxicity of Average Pesticide Concentrations and Time-Variable Exposures from Water Quality Monitoring
Effect Modeling Quantifies the Difference Between the Toxicity of Average Pesticide Concentrations and Time-Variable Exposures from Water Quality Monitoring Open
Synthetic chemicals are frequently detected in water bodies, and their concentrations vary over time. Water monitoring programs typically employ either a sequence of grab samples or continuous sampling, followed by chemical analysis. Conti…
View article: Sublethal effect modelling for environmental risk assessment of chemicals: Problem definition, model variants, application and challenges
Sublethal effect modelling for environmental risk assessment of chemicals: Problem definition, model variants, application and challenges Open
Bioenergetic models, and specifically dynamic energy budget (DEB) theory, are gathering a great deal of interest as a tool to predict the effects of realistically variable exposure to toxicants over time on an individual animal. Here we us…
View article: A knowledge-based approach to designing control strategies for agricultural pests
A knowledge-based approach to designing control strategies for agricultural pests Open