Roman Eickhoff
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View article: Novel Silk Fibroin Based Bilayer Scaffolds for Bioabsorbable Internal Biliary Stenting
Novel Silk Fibroin Based Bilayer Scaffolds for Bioabsorbable Internal Biliary Stenting Open
Biliary duct reconstruction is one of the most challenging parts of liver transplantation and accounts for 40%–60% of complications. While current stent‐based devices on the market show promising results in reducing complications, they are…
View article: Sleeve-gastrectomy results in improved metabolism and a massive stress response of the liver proteome in a mouse model of metabolic dysfunction-associated steatohepatitis
Sleeve-gastrectomy results in improved metabolism and a massive stress response of the liver proteome in a mouse model of metabolic dysfunction-associated steatohepatitis Open
The rapid weight loss and decrease of hepatic fat after SG lead to a proinflammatory response in the liver in the early phase after surgery, which changes to a more moderate immune response in the long-term. We suggest a preoperative risk …
View article: Identifying radiomics signatures in body composition imaging for the prediction of outcome following pancreatic cancer resection
Identifying radiomics signatures in body composition imaging for the prediction of outcome following pancreatic cancer resection Open
Background Computerized radiological image analysis (radiomics) enables the investigation of image-derived phenotypes by extracting large numbers of quantitative features. We hypothesized that radiomics features may contain prognostic info…
View article: Choice of Polymer, but Not Mesh Structure Variation, Reduces the Risk of Bacterial Infection with Staphylococcus aureus In Vivo
Choice of Polymer, but Not Mesh Structure Variation, Reduces the Risk of Bacterial Infection with Staphylococcus aureus In Vivo Open
Background: Synthetic mesh material is of great importance for surgical incisional hernia repair. The physical and biochemical characteristics of the mesh influence mechanical stability and the foreign body tissue reaction. The influence o…
View article: The impact of the COVID-19 outbreak on emergency general surgery in the first German “hotspot region” Aachen-Heinsberg–A multicentre retrospective cohort study
The impact of the COVID-19 outbreak on emergency general surgery in the first German “hotspot region” Aachen-Heinsberg–A multicentre retrospective cohort study Open
This study aimed to observe the impact of the COVID-19 outbreak on acute general surgery in the first German “hotspot” regions of Heinsberg and Aachen, during the first months of the pandemic. The incidence and severity of acute appendicit…
View article: Ultra-Fine Polyethylene Hernia Meshes Improve Biocompatibility and Reduce Intraperitoneal Adhesions in IPOM Position in Animal Models
Ultra-Fine Polyethylene Hernia Meshes Improve Biocompatibility and Reduce Intraperitoneal Adhesions in IPOM Position in Animal Models Open
(1) Introduction: The intraperitoneal onlay mesh technique (IPOM) is widely used to repair incisional hernias. This method has advantages but suffers from complications due to intraperitoneal adhesion formation between the mesh and intesti…
View article: Novel Elastic Threads for Intestinal Anastomoses: Feasibility and Mechanical Evaluation in a Porcine and Rabbit Model
Novel Elastic Threads for Intestinal Anastomoses: Feasibility and Mechanical Evaluation in a Porcine and Rabbit Model Open
Gastrointestinal anastomoses are an important source of postoperative complications. In particular, the ideal suturing material is still the subject of investigation. Therefore, this study aimed to evaluate a newly developed suturing mater…
View article: Machine learning prediction model for postoperative outcome after perforated appendicitis
Machine learning prediction model for postoperative outcome after perforated appendicitis Open
Purpose Appendectomy for acute appendicitis is one of the most common operative procedures worldwide in both children and adults. In particular, complicated (perforated) cases show high variability in individual outcomes. Here, we develope…
View article: Deletion of <scp>mTOR</scp> in liver epithelial cells enhances hepatic metastasis of colon cancer
Deletion of <span>mTOR</span> in liver epithelial cells enhances hepatic metastasis of colon cancer Open
Activation of the mechanistic target of rapamycin (mTOR) pathway is frequently found in cancer, but mTOR inhibitors have thus far failed to demonstrate significant antiproliferative efficacy in the majority of cancer types. Besides cancer …
View article: CT-Based Prediction of Liver Function and Post-PVE Hypertrophy Using an Artificial Neural Network
CT-Based Prediction of Liver Function and Post-PVE Hypertrophy Using an Artificial Neural Network Open
Background: This study aimed to evaluate whether hypertrophy after portal vein embolization (PVE) and maximum liver function capacity (LiMAx) are predictable by an artificial neural network (ANN) model based on computed tomography (CT) tex…
View article: Safety of laparoscopic hepatectomy in patients with severe comorbidities ‐ A propensity score matched analysis
Safety of laparoscopic hepatectomy in patients with severe comorbidities ‐ A propensity score matched analysis Open
Background Laparoscopic hepatectomy (LH) is nowadays considered as the standard of care for various liver malignancies. However, studies focusing on perioperative outcome after LH in patients with severe comorbidities are still sparse. Met…
View article: Operative Time, Age, and Serum Albumin Predict Surgical Morbidity After Laparoscopic Liver Surgery
Operative Time, Age, and Serum Albumin Predict Surgical Morbidity After Laparoscopic Liver Surgery Open
Background. Laparoscopic liver resection (LLR) has emerged as a considerable alternative to conventional liver surgery. However, the increasing complexity of liver resection raises the incidence of postoperative complications. The aim of t…
View article: Laparoscopic hepatectomy reduces postoperative complications and hospital stay in overweight and obese patients
Laparoscopic hepatectomy reduces postoperative complications and hospital stay in overweight and obese patients Open
LH is safe and cost-effective in overweight and obese patients. Furthermore, LH is significantly associated with fewer postoperative complications and reduced hospital stay compared to OH in these patients.
View article: Cross‐section modified and highly elastic sutures reduce tissue incision and show comparable biocompatibility: in‐vitro and in‐vivo evaluation of novel thermoplastic urethane surgical threads
Cross‐section modified and highly elastic sutures reduce tissue incision and show comparable biocompatibility: in‐vitro and in‐vivo evaluation of novel thermoplastic urethane surgical threads Open
Surgical sutures are indispensable for a vast majority of operative procedures. An ideal suture is characterized by high tissue compliance without cutting into the mended tissue and optimal biocompatibility. Therefore, we assessed these me…
View article: Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition
Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition Open
Activation of the mTOR pathway is frequently found in cancer, but mTOR inhibitors have thus far failed to demonstrate significant antiproliferative efficacy in the majority of cancer types. Besides cancer cell-intrinsic resistance mechanis…
View article: Mouse Models of Nonalcoholic Steatohepatitis: Head-to-Head Comparison of Dietary Models and Impact on Inflammation and Animal Welfare
Mouse Models of Nonalcoholic Steatohepatitis: Head-to-Head Comparison of Dietary Models and Impact on Inflammation and Animal Welfare Open
A variety of dietary nonalcoholic steatohepatitis (NASH) mouse models are available, and choosing the appropriate mouse model is one of the most important steps in the design of NASH studies. In addition to the histopathological and metabo…
View article: A Newly Established Murine Cell Line as a Model for Hepatocellular Cancer in Non-Alcoholic Steatohepatitis
A Newly Established Murine Cell Line as a Model for Hepatocellular Cancer in Non-Alcoholic Steatohepatitis Open
Non-alcoholic steatohepatitis (NASH) has become a major risk factor for hepatocellular cancer (HCC) due to the worldwide increasing prevalence of obesity. However, the pathophysiology of NASH and its progression to HCC is incompletely unde…
View article: Incisional Hernia After Liver Transplantation: Analysis of Tailored Open Mesh Repair
Incisional Hernia After Liver Transplantation: Analysis of Tailored Open Mesh Repair Open
Objective Incisional hernia is a frequent complication post liver transplantation (LT). The aim of this study was to compare divergent approaches to open abdominal wall repair post-LT. Summary of background data After liver transplantation…
View article: A New Physiologic Mouse Model of One Anastomosis Gastric Bypass
A New Physiologic Mouse Model of One Anastomosis Gastric Bypass Open
Background: One anastomosis gastric bypass (OAGB) is a modern metabolic operation that has been demonstrated to be a rapid, safe, and effective procedure. As for other bariatric operations, the mechanisms and long-term effects of this proc…
View article: Supplementary Material for: A New Physiologic Mouse Model of One Anastomosis Gastric Bypass
Supplementary Material for: A New Physiologic Mouse Model of One Anastomosis Gastric Bypass Open
Background: One anastomosis gastric bypass (OAGB) is a modern metabolic operation that has been demonstrated to be a rapid, safe, and effective procedure. As for other bariatric operations, the mechanisms and long-term effects of this proc…
View article: Long-term outcome and quality of life after initial and repeat resection of colorectal liver metastasis: A retrospective analysis
Long-term outcome and quality of life after initial and repeat resection of colorectal liver metastasis: A retrospective analysis Open
Repeat hepatic resection for CRLM is as effective as primary surgical treatment in terms of OS and QoL. Patients should be selected carefully concerning prognostic factors as DFS is decreased after repeat hepatic resection.
View article: Port-site incisional hernia - A case series of 54 patients
Port-site incisional hernia - A case series of 54 patients Open
In Port sites of 10 mm and larger diameter fascia should be closed by suture, whereas the risk of hernia development in 5 mm trocar placements seems to be a rare complication. Port-site incisional hernia should be treated by suture or mesh…