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Publisher Correction: Functional synapses between neurons and small cell lung cancer Open

Vignesh Sakthivelu, Anna Schmitt, Franka Odenthal, Kristiano Ndoci, Marian Touet , et al. · 2025

Functional synapses between neurons and small cell lung cancer Open

Vignesh Sakthivelu, Anna Schmitt, Franka Odenthal, Kristiano Ndoci, Marian Touet , et al. · 2025

Small cell lung cancer (SCLC) is a highly aggressive type of lung cancer, characterized by rapid proliferation, early metastatic spread, frequent early relapse and a high mortality rate 1–3 . Recent evidence has suggested that innervation …

Data from Genetic Screens Identify a Context-Specific PI3K/p27<sup>Kip1</sup> Node Driving Extrahepatic Biliary Cancer Open

Chiara Falcomatà, Stefanie Bärthel, Angelika Ulrich, Sandra Diersch, Christian Veltkamp , et al. · 2023

Biliary tract cancer ranks among the most lethal human malignancies, representing an unmet clinical need. Its abysmal prognosis is tied to an increasing incidence and a fundamental lack of mechanistic knowledge regarding the molecular basi…

Supplementary Table 1 from Genetic Screens Identify a Context-Specific PI3K/p27<sup>Kip1</sup> Node Driving Extrahepatic Biliary Cancer Open

Chiara Falcomatà, Stefanie Bärthel, Angelika Ulrich, Sandra Diersch, Christian Veltkamp , et al. · 2023

Common insertion sites of piggyBac transposon mutagenesis screen.

Supplementary Figures and Methods from Genetic Screens Identify a Context-Specific PI3K/p27<sup>Kip1</sup> Node Driving Extrahepatic Biliary Cancer Open

Chiara Falcomatà, Stefanie Bärthel, Angelika Ulrich, Sandra Diersch, Christian Veltkamp , et al. · 2023

Supplementary graphical abstract, eight Supplemental Figures, Supplementary Methods

Data from Genetic Screens Identify a Context-Specific PI3K/p27<sup>Kip1</sup> Node Driving Extrahepatic Biliary Cancer Open

Chiara Falcomatà, Stefanie Bärthel, Angelika Ulrich, Sandra Diersch, Christian Veltkamp , et al. · 2023

Biliary tract cancer ranks among the most lethal human malignancies, representing an unmet clinical need. Its abysmal prognosis is tied to an increasing incidence and a fundamental lack of mechanistic knowledge regarding the molecular basi…

Supplementary Table 1 from Genetic Screens Identify a Context-Specific PI3K/p27<sup>Kip1</sup> Node Driving Extrahepatic Biliary Cancer Open

Chiara Falcomatà, Stefanie Bärthel, Angelika Ulrich, Sandra Diersch, Christian Veltkamp , et al. · 2023

Common insertion sites of piggyBac transposon mutagenesis screen.

Supplementary Figures and Methods from Genetic Screens Identify a Context-Specific PI3K/p27<sup>Kip1</sup> Node Driving Extrahepatic Biliary Cancer Open

Chiara Falcomatà, Stefanie Bärthel, Angelika Ulrich, Sandra Diersch, Christian Veltkamp , et al. · 2023

Supplementary graphical abstract, eight Supplemental Figures, Supplementary Methods

Functional synapses between small cell lung cancer and glutamatergic neurons Open

Anna Schmitt, Vignesh Sakthivelu, Kristiano Ndoci, Gulzar A. Wani, Marian Touet , et al. · 2023

Small cell lung cancer (SCLC) is a highly aggressive type of lung cancer, characterized by rapid proliferation, early metastatic spread, clinical recurrence and high rate of mortality. Using in vivo insertional mutagenesis screening in con…

Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment Open

Chiara Falcomatà, Stefanie Bärthel, Sebastian A. Widholz, Christian Schneeweis, Juán José Montero , et al. · 2022

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma Open

Markus Schick, Le Zhang, Sabine Maurer, H. Carlo Maurer, Konstandina Isaakaidis , et al. · 2022

Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary Cancer Open

Chiara Falcomatà, Stefanie Bärthel, Angelika Ulrich, Sandra Diersch, Christian Veltkamp , et al. · 2021

Biliary tract cancer ranks among the most lethal human malignancies, representing an unmet clinical need. Its abysmal prognosis is tied to an increasing incidence and a fundamental lack of mechanistic knowledge regarding the molecular basi…

Implementing cell-free DNA of pancreatic cancer patient–derived organoids for personalized oncology Open

Zahra Dantes, Hsi-Yu Yen, Nicole Pfarr, Christof Winter, Katja Steiger , et al. · 2020

One of the major challenges in using pancreatic cancer patient-derived organoids (PDOs) in precision oncology is the time from biopsy to functional characterization. This is particularly true for endoscopic ultrasound-guided fine-needle as…

Abstract 391: Evolutionary trajectories and <i>KRAS</i> gene dosage define pancreatic cancer phenotypes Open

Sebastian Mueller, Thomas Engleitner, Roman Maresch, Magdalena Żukowska, Sebastian Lange , et al. · 2018

Pancreatic ductal adenocarcinoma (PDAC) has frequent alterations in few genes (KRAS, CDKN2A/TP53/SMAD4) and extensive heterogeneity of cancer drivers beyond. The expectation that mutational landscapes of rare drivers could explain phenotyp…

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes Open

Sebastian Mueller, Thomas Engleitner, Roman Maresch, Magdalena Żukowska, Sebastian Lange , et al. · 2018

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis Open

Tim Wartewig, Zsuzsanna Kurgyis, Selina J. Keppler, Konstanze Pechloff, Erik Hameister , et al. · 2017

Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice Open

Roman Maresch, Sebastian Mueller, Christian Veltkamp, Rupert Öllinger, Mathias Friedrich , et al. · 2016

Mouse transgenesis has provided fundamental insights into pancreatic cancer, but is limited by the long duration of allele/model generation. Here we show transfection-based multiplexed delivery of CRISPR/Cas9 to the pancreas of adult mice,…

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice Open

Julia Weber, Rupert Öllinger, Mathias Friedrich, Ursula Ehmer, Maxim Barenboim , et al. · 2015

Significance Assigning biological relevance and molecular function to large catalogues of mutated genes in cancer is a major challenge. Likewise, pinpointing drivers among thousands of transcriptionally or epigenetically dysregulated genes…

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