Román Serrat
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View article: Astrocyte CB<sub>1</sub>receptors drive blood-brain barrier disruption in CNS inflammatory disease
Astrocyte CB<sub>1</sub>receptors drive blood-brain barrier disruption in CNS inflammatory disease Open
Reactive astrocytes shape central nervous system (CNS) inflammation and participate in myelin damage and repair mechanisms in multiple sclerosis (MS). Through the activation of cannabinoid CB 1 receptors (CB 1 R) expressed by neurons and o…
View article: Astroglial <scp>CB<sub>1</sub></scp> Reveal Sex‐Specific Synaptic Effects of Amphetamine
Astroglial <span>CB<sub>1</sub></span> Reveal Sex‐Specific Synaptic Effects of Amphetamine Open
The Nucleus Accumbens (NAc) is a critical brain region for the effects of psychostimulant drugs. Type‐1 cannabinoid receptors (CB 1 ), the main elements of the endocannabinoid system (ECS) in the brain, participate in these effects and mod…
View article: Autoimmune inflammation triggers aberrant astrocytic calcium signaling to impair synaptic plasticity
Autoimmune inflammation triggers aberrant astrocytic calcium signaling to impair synaptic plasticity Open
Cortical pathology involving inflammatory and neurodegenerative mechanisms is a hallmark of multiple sclerosis (MS) and a correlate of disease progression and cognitive decline. Astrocytes play a pivotal role in MS initiation and progressi…
View article: A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes
A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes Open
Control of brain energy metabolism and regulation of synaptic activity through gliotransmission are two important ways, through which astrocytes contribute to mental functions. However, the potential functional and molecular links between …
View article: Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration
Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration Open
(Cell Reports 37, 110133; December 21, 2021) In the version of this article that was originally published with the December 21, 2021 issue of Cell Reports, the legend of Figure 2, the key resources table, and “immunocytochemistry” section …
View article: ER-mitochondria contacts underline cannabinoid regulation of calcium signaling in astrocytes
ER-mitochondria contacts underline cannabinoid regulation of calcium signaling in astrocytes Open
Intracellular calcium signaling underlies the astroglial control of brain functions. However, the cellular mechanisms regulating calcium handling by astrocytes are far from being understood. Mitochondria-endoplasmic reticulum contacts (MER…
View article: ARMCX3 Mediates Susceptibility to Hepatic Tumorigenesis Promoted by Dietary Lipotoxicity
ARMCX3 Mediates Susceptibility to Hepatic Tumorigenesis Promoted by Dietary Lipotoxicity Open
ARMCX3 is encoded by a member of the Armcx gene family and is known to be involved in nervous system development and function. We found that ARMCX3 is markedly upregulated in mouse liver in response to high lipid availability, and that hep…
View article: Astroglial calcium transfer from endoplasmic reticulum to mitochondria determines synaptic integration
Astroglial calcium transfer from endoplasmic reticulum to mitochondria determines synaptic integration Open
Summary Intracellular calcium signaling underlies the astroglial control of synaptic transmission and plasticity. Mitochondria-endoplasmic reticulum contacts (MERCs) are key determinants of calcium dynamics, but their functional impact on …
View article: Mitochondrial morphology and cellular distribution are altered in SPG31 patients and are linked to DRP1 hyperphosphorylation
Mitochondrial morphology and cellular distribution are altered in SPG31 patients and are linked to DRP1 hyperphosphorylation Open
Hereditary spastic paraplegia, SPG31, is a rare neurological disorder caused by mutations in REEP1 gene encoding the microtubule-interacting protein, REEP1. The mechanism by which REEP1-dependent processes are linked with the disease is un…