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View article: Zebrafish fast muscle contractions avoid the mammalian requirement for voltage-gated Na+ channels
Zebrafish fast muscle contractions avoid the mammalian requirement for voltage-gated Na+ channels Open
Fast skeletal muscle fibers from zebrafish share a number of functional properties with mammalian twitch muscle fibers, making this vertebrate a precious model to investigate the pathophysiology of neuromuscular disorders. We previously re…
Col6 deficiency in a zebrafish model of Bethlem myopathy leads to dysfunction of the muscle dihydropyridine receptor Open
Bethlem myopathy (BM) is an incurable muscle disease characterized by joint contractures and muscle weakness worsening with age. BM results from mutations in genes encoding one of the three α chains of collagen VI (ColVI), a component of t…
A mechano- and heat-gated two-pore domain K <sup>+</sup> channel controls excitability in adult zebrafish skeletal muscle Open
TRAAK channels are mechano-gated two-pore-domain K + channels. Up to now, activity of these channels has been reported in neurons but not in skeletal muscle, yet an archetype of tissue challenged by mechanical stress. Using patch clamp met…
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers Open
The zebrafish has emerged as a very relevant animal model for probing the pathophysiology of human skeletal muscle disorders. This vertebrate animal model displays a startle response characterized by high-frequency swimming activity powere…
Mammalian skeletal muscle does not express functional voltage-gated H<sup>+</sup> channels Open
High metabolic activity and existence of a large transmembrane inward electrochemical gradient for H + at rest promote intracellular acidification of skeletal muscle. Exchangers and cotransports efficiently contend against accumulation of …