Romel Hernández‐Bello
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View article: The Sexual Dimorphism of the Neuroimmune Response in the Brains of Taenia crassiceps-Infected Mice
The Sexual Dimorphism of the Neuroimmune Response in the Brains of Taenia crassiceps-Infected Mice Open
Background: Helminth infections are associated with cognitive deficits, especially in school-age children. Deworming treatment in heavily infected children improves their short- and long-term memory recall. In mice, intraperitoneal helmint…
View article: New Uses for Old Drugs and Their Application in Helminthology
New Uses for Old Drugs and Their Application in Helminthology Open
Parasitic infection research, performed on both humans and domestic animals, has been mostly focused on vaccines, diagnostic methods, epidemiology, and the evolutionary origins of parasites, thanks to the emergence of genomics and proteomi…
View article: Safety profile of intravenous administration of live<i>Pichia pastoris</i>cells in mice
Safety profile of intravenous administration of live<i>Pichia pastoris</i>cells in mice Open
Pichia pastoris has been widely used to produce antigenic proteins aimed to integrate subunit vaccines. Moreover, increasing interest in large-scale vaccine production at the lowest cost is rapidly focusing in the development of yeast surf…
View article: Molecular Characterization of a Functional Membrane-Associated Progesterone Receptor Component 2 (PGRMC-2) in Maturing Oocytes of the Human Parasite Nematode <i>Trichinella spiralis</i>: Implications to the Host-Parasite Relationship
Molecular Characterization of a Functional Membrane-Associated Progesterone Receptor Component 2 (PGRMC-2) in Maturing Oocytes of the Human Parasite Nematode <i>Trichinella spiralis</i>: Implications to the Host-Parasite Relationship Open
We explored the hypothesis that progesterone direct effect on Trichinella spiralis might be mediated indeed by a new steroid-binding parasite protein. Our first results showed that Progesterone decreases the parasite molting rate. We ampli…
View article: Expression of recombinant protease MarP from Mycobacterium tuberculosis in Pichia pastoris and its effect on human monocytes
Expression of recombinant protease MarP from Mycobacterium tuberculosis in Pichia pastoris and its effect on human monocytes Open
Mycobacterial MarP was successfully expressed in P. pastoris, and it is capable of cytokine release in vitro.
View article: The deficiency of myelin in the mutant taiep rat induces a differential immune response related to protection from the human parasite Trichinella spiralis
The deficiency of myelin in the mutant taiep rat induces a differential immune response related to protection from the human parasite Trichinella spiralis Open
Taiep rat is a myelin mutant with a progressive motor syndrome characterized by tremor, ataxia, immobility episodes, epilepsy and paralysis of the hindlimbs. Taiep had an initial hypomyelination followed by a progressive demyelination asso…
View article: The lack of myelin in the mutant<i>taiep</i>rat induces a differential immune response related to protection to the human parasite<i>Trichinella spiralis</i>
The lack of myelin in the mutant<i>taiep</i>rat induces a differential immune response related to protection to the human parasite<i>Trichinella spiralis</i> Open
Taiep rat is a myelin mutant with a progressive motor syndrome characterized by tremor, ataxia, immobility episodes, epilepsy and paralysis of the hindlimbs, accompanied with differential expression of interleukins and their receptors that…
View article: Candida albicans and non-albicans Isolates from Bloodstream Have Different Capacities to Induce Neutrophil Extracellular Traps
Candida albicans and non-albicans Isolates from Bloodstream Have Different Capacities to Induce Neutrophil Extracellular Traps Open
Neutrophils activated with pathogens or their products induce formation of extracellular traps (NETs), but if this constitutes a general response against all pathogenic species in a single genus or intrageneric differences exist remains un…
View article: Understanding the Entanglement: Neutrophil Extracellular Traps (NETs) in Cystic Fibrosis
Understanding the Entanglement: Neutrophil Extracellular Traps (NETs) in Cystic Fibrosis Open
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the gene that codes for the CF trans-membrane conductance regulator. These mutations result in abnormal secretions viscous airways of the lungs, favoring pulmon…
View article: Expression of TNFα, IL-10 and IL-6 in spleen of hamsters experimentally infected with <i>T. spiralis</i> at 5 days pi.
Expression of TNFα, IL-10 and IL-6 in spleen of hamsters experimentally infected with <i>T. spiralis</i> at 5 days pi. Open
The 18S was used as control gene of constitutive expression. Optical densitometry (OD) was obtained as a relationship between the genes of interest and 18S, and reported as mean +/− standard deviation. One-way ANOVA. N = 6−15. *** = P<0.00…