Romeo Gabriel Mihăilă
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View article: Cytokine Landscapes, Immune Dysregulation, and Treatment Perspectives in Philadelphia-Negative Myeloproliferative Neoplasms: A Narrative Review
Cytokine Landscapes, Immune Dysregulation, and Treatment Perspectives in Philadelphia-Negative Myeloproliferative Neoplasms: A Narrative Review Open
Philadelphia-negative myeloproliferative neoplasms (Ph-MPNs) are clonal hematologic malignancies characterized not only by driver mutations such as JAK2V617F, CALR, and MPL but also by a profoundly dysregulated immune microenvironment. Chr…
View article: Non-Contrast CT Hemorrhage Markers and Outcomes in Intracerebral Hemorrhage: A Large Single-Center Cohort from Romania
Non-Contrast CT Hemorrhage Markers and Outcomes in Intracerebral Hemorrhage: A Large Single-Center Cohort from Romania Open
Background and Purpose: Spontaneous intracerebral hemorrhage (ICH) is associated with high rates of morbidity and mortality. Early hematoma expansion (HE) is a key driver of poor outcomes, yet readily available non-contrast CT (NCCT) marke…
View article: Intersecting Pathways: The Impact of Philadelphia-Negative Chronic Myeloproliferative Neoplasms on the Pathogenesis and Progression of Heart Failure with Preserved Ejection Fraction
Intersecting Pathways: The Impact of Philadelphia-Negative Chronic Myeloproliferative Neoplasms on the Pathogenesis and Progression of Heart Failure with Preserved Ejection Fraction Open
Background: Heart failure with preserved ejection fraction (HFpEF) is increasingly prevalent worldwide due to ageing and comorbidities. Emerging evidence suggests that Philadelphia-negative chronic myeloproliferative neoplasms (MPNs), part…
View article: Prognostic Factors and Clinical Outcomes of Spontaneous Intracerebral Hemorrhage: Analysis of 601 Consecutive Patients from a Single Center (2017–2023)
Prognostic Factors and Clinical Outcomes of Spontaneous Intracerebral Hemorrhage: Analysis of 601 Consecutive Patients from a Single Center (2017–2023) Open
Background: Spontaneous intracerebral hemorrhage (ICH) has the highest case fatality of all stroke types, yet recent epidemiological and outcome data from Central and Eastern Europe remain limited. Methods: We retrospectively analyzed pros…
View article: Bispecific Antibodies—A New Hope for Patients with Diffuse Large B-Cell Lymphoma
Bispecific Antibodies—A New Hope for Patients with Diffuse Large B-Cell Lymphoma Open
T-cell-engaging antibodies are a promising new type of treatment for patients with refractory or relapsed (R/R) diffuse large B-cell lymphoma, which has changed the prognosis and evolution of these patients in clinical trials. Bispecific a…
View article: Surgical Versus Conservative Management of Supratentorial ICH: A Single-Center Retrospective Analysis (2017–2023)
Surgical Versus Conservative Management of Supratentorial ICH: A Single-Center Retrospective Analysis (2017–2023) Open
Background: Intracerebral hemorrhage (ICH) is a severe form of stroke associated with high morbidity and mortality. While neurosurgical evacuation may offer theoretical benefits, its impact on survival and hospital course remains debated. …
View article: Liver and Vascular Involvement in Philadelphia-Negative Chronic Myeloproliferative Neoplasms—A Narrative Review
Liver and Vascular Involvement in Philadelphia-Negative Chronic Myeloproliferative Neoplasms—A Narrative Review Open
Hepatosplenomegaly can occur in extrahepatic diseases such as Philadelphia-negative chronic myeloproliferative neoplasms (MPNs), which may involve the liver and vasculature. In myelofibrosis, extramedullary hematopoiesis can be present in …
View article: Prognostic Value of Four CT-Based Hemorrhage Markers: A Single-Center ICH Study (2017–2023)
Prognostic Value of Four CT-Based Hemorrhage Markers: A Single-Center ICH Study (2017–2023) Open
Background and Purpose: Spontaneous intracerebral hemorrhage (ICH) is a severe stroke subtype characterized by high morbidity and mortality. Early hematoma expansion (HE) predicts poor outcomes, yet non-contrast CT (NCCT) markers that can …
View article: P051: Exploring the clinical utility of Oncotype DX in ER+/HER2-, N0 and N1 breast cancer patients: Insights from a Romanian cohort
P051: Exploring the clinical utility of Oncotype DX in ER+/HER2-, N0 and N1 breast cancer patients: Insights from a Romanian cohort Open
View article: Non-Surgical Management of Gallstones During Pregnancy: A Clinical Case Report
Non-Surgical Management of Gallstones During Pregnancy: A Clinical Case Report Open
Gallstone disease during pregnancy, or cholelithiasis, presents significant clinical challenges due to hormonal, anatomical, and metabolic changes. Progesterone therapy, commonly used in pregnancy for uterine bleeding, can exacerbate galls…
View article: Anticoagulation Reversal in Intracerebral Hemorrhage: A Case Report on the Efficacy of Andexanet Alfa in an Apixaban-Treated Patient
Anticoagulation Reversal in Intracerebral Hemorrhage: A Case Report on the Efficacy of Andexanet Alfa in an Apixaban-Treated Patient Open
Intracerebral hemorrhage (ICH) presents complex clinical challenges, particularly in patients receiving anticoagulation therapy. This case report discusses the management of acute ICH in a 60-year-old male patient on long-term apixaban the…
View article: Bridging Periodontal Disease and Myeloproliferative Neoplasms: The Role of Immune Dysregulation and Inflammatory Mediators
Bridging Periodontal Disease and Myeloproliferative Neoplasms: The Role of Immune Dysregulation and Inflammatory Mediators Open
Periodontal disease (PD) and myeloproliferative neoplasms (MPNs) are linked through common inflammatory mediators and immune dysregulation. Chronic inflammation plays a pivotal role in both conditions, with markers such as Chitinase-3-like…
View article: Challenges and Complications in Treating Total Knee Arthroplasty in Morbidly Obese Patients
Challenges and Complications in Treating Total Knee Arthroplasty in Morbidly Obese Patients Open
View article: Cardiovascular Risk in Philadelphia-Negative Myeloproliferative Neoplasms: Mechanisms and Implications—A Narrative Review
Cardiovascular Risk in Philadelphia-Negative Myeloproliferative Neoplasms: Mechanisms and Implications—A Narrative Review Open
Myeloproliferative neoplasms (MPNs), encompassing disorders like polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are characterized by clonal hematopoiesis without the Philadelphia chromosome. The JA…
View article: Diagnostic Values of Serum Inflammatory Biomarkers after Hip and Knee Arthroplasty in Patients with Periprosthetic Joint Infection
Diagnostic Values of Serum Inflammatory Biomarkers after Hip and Knee Arthroplasty in Patients with Periprosthetic Joint Infection Open
One of the complications after total hip arthroplasty (THA) or total knee arthroplasty (TKA) is periprosthetic joint infection (PJI). Numerous studies have been performed to explore the value of biological parameters in the early identific…
View article: The Impact of Anemia on the Survival of Patients Diagnosed With Low-Grade Malignant B-cell Lymphomas
The Impact of Anemia on the Survival of Patients Diagnosed With Low-Grade Malignant B-cell Lymphomas Open
In our cohort, subjects with the lowest Hb value at diagnosis had the worst survival. The results of our study conclude that anemia represents a negative impact factor not only on the patient's quality of life but also on their survival.
View article: Incidence of Subclinical Deep Vein Thrombosis after Total Hip and Knee Arthroplasty Is Not Correlated with Number of Tranexamic Acid Doses
Incidence of Subclinical Deep Vein Thrombosis after Total Hip and Knee Arthroplasty Is Not Correlated with Number of Tranexamic Acid Doses Open
Background: Recent studies increasingly highlight the efficacy of tranexamic acid administration in total hip arthroplasty (THA) and total knee arthroplasty (TKA). However, the optimal dosage of tranexamic acid is still controversial. Meth…
View article: Challenges associated with the use of Bruton's tyrosine kinase inhibitors: A life‑saving therapy for chronic lymphocytic leukemia (Review)
Challenges associated with the use of Bruton's tyrosine kinase inhibitors: A life‑saving therapy for chronic lymphocytic leukemia (Review) Open
The adverse effects (AEs) of chemotherapy for chronic lymphocytic leukemia (CLL) can currently be avoided using Bruton's tyrosine kinase inhibitors (BTKis) and/or B‑cell leukemia/lymphoma 2 (BCL2) inhibitors, which have increased the effic…
View article: Automated Machine Learning to Develop Predictive Models of Metabolic Syndrome in Patients with Periodontal Disease
Automated Machine Learning to Develop Predictive Models of Metabolic Syndrome in Patients with Periodontal Disease Open
Metabolic syndrome is experiencing a concerning and escalating rise in prevalence today. The link between metabolic syndrome and periodontal disease is a highly relevant area of research. Some studies have suggested a bidirectional relatio…
View article: Interactions between Metabolic Syndrome, MASLD, and Arterial Stiffening: A Single-Center Cross-Sectional Study
Interactions between Metabolic Syndrome, MASLD, and Arterial Stiffening: A Single-Center Cross-Sectional Study Open
Metabolic-associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty liver disease (NAFLD), has emerged as a prominent global cause of chronic liver disease and is increasingly recognized as associated with atheroscl…
View article: IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid Artery
IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid Artery Open
Background and Objectives: Stroke is a leading cause of mortality and morbidity worldwide. Treatment of this pathology is still under development and its risk factors remain to be determined. Therefore, we aim to determine the role of inte…
View article: IL1beta—Biomarker for Ischemic Stroke Prognosis and Carotid Atheromatosis
IL1beta—Biomarker for Ischemic Stroke Prognosis and Carotid Atheromatosis Open
Background and Objectives: Stroke is a main leading cause for mortality and morbidity worldwide. Treat-ment of this pathology is still under development and its risk factors remain the main target to be reached. Therefore, we aim to determ…
View article: Hepatic Involvement across the Metabolic Syndrome Spectrum: Non-Invasive Assessment and Risk Prediction Using Machine Learning
Hepatic Involvement across the Metabolic Syndrome Spectrum: Non-Invasive Assessment and Risk Prediction Using Machine Learning Open
Metabolic-dysfunction-associated steatotic liver disease (MASLD) and metabolic syndrome (MetS) are inextricably linked conditions, both of which are experiencing an upward trend in prevalence, thereby exerting a substantial clinical and ec…
View article: A Severity Score and Outcome Prediction in Patients that Suffered an Ischemic Stroke
A Severity Score and Outcome Prediction in Patients that Suffered an Ischemic Stroke Open
Background. Stroke is the main cause of disability and exitus worldwide. The prediction of mortality of this pathology represents a major challenge. More than that, the infection with the SARS-CoV-2 virus is a challenge for every clinician…
View article: Prognostic markers for ischemic stroke – are they truly reliable?
Prognostic markers for ischemic stroke – are they truly reliable? Open
Background. Stroke is one of the leading causes of mortality and morbidity worldwide. Despite extensive research, to this date there is no panel of biomarkers for the prevention and prognosis of ischemic stroke and there is still much inco…
View article: From a bispecific monoclonal antibody to gene therapy: A new era in the treatment of hemophilia A
From a bispecific monoclonal antibody to gene therapy: A new era in the treatment of hemophilia A Open
The treatment of hemophilia A has progressed amazingly in recent years. Emicizumab, a bispecific-humanized monoclonal antibody, is able to improve coagulation by bridging activated factor IX and factor X. Emicizumab is administered subcuta…
View article: Role of biological markers and CT severity score in predicting mortality in patients with COVID‑19: An observational retrospective study
Role of biological markers and CT severity score in predicting mortality in patients with COVID‑19: An observational retrospective study Open
COVID-19 pandemic is a continuing ongoing emergency of public concern. Early identification of markers associated with disease severity and mortality can lead to a prompter therapeutic approach. The present study conducted a multivariate a…
View article: The Influence of Periodontal Disease on Oral Health Quality of Life in Patients with Cardiovascular Disease: A Cross-Sectional Observational Single-Center Study
The Influence of Periodontal Disease on Oral Health Quality of Life in Patients with Cardiovascular Disease: A Cross-Sectional Observational Single-Center Study Open
Background and Objectives: Cardiovascular disease is a leading cause of global death with a rising prevalence and a heavy economic burden. Periodontal disease has been associated with cardiovascular diseases—including incident coronary hea…
View article: Warfarin involvement, in comparison to NOACs, in the development of systemic atherosclerosis
Warfarin involvement, in comparison to NOACs, in the development of systemic atherosclerosis Open
Adverse effects of drugs are one of the objective criteria used for choosing the most appropriate anticoagulant. It is worrying that warfarin may be involved in the progression of systemic atherosclerosis, as more and more articles suggest…
View article: Assessment of Biological Parameters that (Influence) Affect the Quality of Life in a Group of Patients with Metabolic Syndrome
Assessment of Biological Parameters that (Influence) Affect the Quality of Life in a Group of Patients with Metabolic Syndrome Open
The study included a group of 42 patients with metabolic syndrome and 32 patients without metabolic syndrome. The following biological data: BMI, blood pressure, type 2 diabetes, low HDL cholesterol levels were statistically compared using…