Romesh R. Subramanian
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View article: A Triple-Precursor Blend as a Topical Solution to Protect the Skin Against Environmental Damage
A Triple-Precursor Blend as a Topical Solution to Protect the Skin Against Environmental Damage Open
The epidermis acts as the body’s primary defense, relying on components like lipids, HA and GSH for skin barrier function, hydration and resistance to oxidative stress. However, limitations in the topical application of these biomolecules …
View article: FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models
FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models Open
View article: Supplementary Data from 14-3-3η Amplifies Androgen Receptor Actions in Prostate Cancer
Supplementary Data from 14-3-3η Amplifies Androgen Receptor Actions in Prostate Cancer Open
Supplementary Data from 14-3-3η Amplifies Androgen Receptor Actions in Prostate Cancer
View article: Supplementary Data from 14-3-3η Amplifies Androgen Receptor Actions in Prostate Cancer
Supplementary Data from 14-3-3η Amplifies Androgen Receptor Actions in Prostate Cancer Open
Supplementary Data from 14-3-3η Amplifies Androgen Receptor Actions in Prostate Cancer
View article: Data from 14-3-3η Amplifies Androgen Receptor Actions in Prostate Cancer
Data from 14-3-3η Amplifies Androgen Receptor Actions in Prostate Cancer Open
Purpose: Androgen receptor abundance and androgen receptor–regulated gene expression in castration-recurrent prostate cancer are indicative of androgen receptor activation in the absence of testicular androgen. Androgen receptor tra…
View article: Data from 14-3-3η Amplifies Androgen Receptor Actions in Prostate Cancer
Data from 14-3-3η Amplifies Androgen Receptor Actions in Prostate Cancer Open
Purpose: Androgen receptor abundance and androgen receptor–regulated gene expression in castration-recurrent prostate cancer are indicative of androgen receptor activation in the absence of testicular androgen. Androgen receptor tra…
View article: Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in <i>mdx</i> mice
Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in <i>mdx</i> mice Open
Current therapies for Duchenne muscular dystrophy (DMD) use phosphorodiamidate morpholino oligomers (PMO) to induce exon skipping in the dystrophin pre-mRNA, enabling the translation of a shortened but functional dystrophin protein. This s…
View article: 14-3-3 Amplifies Androgen Receptor Actions in Prostate Cancer
14-3-3 Amplifies Androgen Receptor Actions in Prostate Cancer Open
Androgen receptor (AR) abundance and AR-regulated gene expression in castration-recurrent prostate cancer (CaP) are indicative of AR activation in the absence of testicular androgen. AR transactivation of target genes in castration-recurre…
View article: Graphical Abstract: Angew. Chem. Int. Ed. 39/2020
Graphical Abstract: Angew. Chem. Int. Ed. 39/2020 Open
report on the modulation of benzothiadiazole-based covalent organic frameworks through halogenation for enhanced photocatalytic water splitting. Drug DeliveryMetal-organic frameworks designed to mimic the structure and surface functions of…
View article: Arginase I mRNA therapy – a novel approach to rescue arginase 1 enzyme deficiency
Arginase I mRNA therapy – a novel approach to rescue arginase 1 enzyme deficiency Open
Arginase I (ARG1) deficiency is an autosomal recessive urea cycle disorder, caused by deficiency of the enzyme Arginase I, resulting in accumulation of arginine in blood. Current Standard of Care (SOC) for ARG1 deficiency in patients or th…
View article: SERPINA1 mRNA as a Treatment for Alpha-1 Antitrypsin Deficiency
SERPINA1 mRNA as a Treatment for Alpha-1 Antitrypsin Deficiency Open
Alpha-1-antitrypsin (AAT) deficiency is a genetic disorder that produces inactive/defective AAT due to mutations in the SERPINA1 gene encoding AAT. This disease is associated with decreased activity of AAT in the lungs and deposition of ex…
View article: mRNA treatment produces sustained expression of enzymatically active human ADAMTS13 in mice
mRNA treatment produces sustained expression of enzymatically active human ADAMTS13 in mice Open
View article: Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA
Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA Open
mRNA based therapies hold great promise for the treatment of genetic diseases. However, this therapeutic approach suffers from multiple challenges including the short half-life of exogenously administered mRNA and subsequent protein produc…
View article: G6PC mRNA Therapy Positively Regulates Fasting Blood Glucose and Decreases Liver Abnormalities in a Mouse Model of Glycogen Storage Disease 1a
G6PC mRNA Therapy Positively Regulates Fasting Blood Glucose and Decreases Liver Abnormalities in a Mouse Model of Glycogen Storage Disease 1a Open
View article: Potential Role of Axonal Chemorepellent Slit2 in Modulating Adventitial Inflammation in a Rat Carotid Artery Balloon Injury Model
Potential Role of Axonal Chemorepellent Slit2 in Modulating Adventitial Inflammation in a Rat Carotid Artery Balloon Injury Model Open
Leukocyte infiltration of adventitial and perivascular tissues is an early event in the development of vascular remodeling after injury. We investigated whether Slit/Robo-an axonal chemorepellent system in vertebrate and invertebrate devel…
View article: Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers
Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers Open
The in vivo potency of antisense oligonucleotides (ASO) has been significantly increased by reducing their length to 8-15 nucleotides and by the incorporation of high affinity RNA binders such as 2', 4'-bridged nucleic acids (also known as…