Romina Libster
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View article: Development and validation of a novel clinical risk score to predict hypoxaemia in children with pneumonia using the WHO PREPARE dataset
Development and validation of a novel clinical risk score to predict hypoxaemia in children with pneumonia using the WHO PREPARE dataset Open
Background Hypoxaemia predicts mortality at all levels of care, and appropriate management can reduce preventable deaths. However, pulse oximetry and oxygen therapy remain inaccessible in many primary care health facilities. We aimed to de…
View article: Development and validation of a novel clinical risk score to predict hypoxemia in children with pneumonia using the WHO PREPARE dataset
Development and validation of a novel clinical risk score to predict hypoxemia in children with pneumonia using the WHO PREPARE dataset Open
Background Hypoxemia predicts mortality at all levels of care, and appropriate management can reduce preventable deaths. However, pulse oximetry and oxygen therapy remain inaccessible in many primary care health facilities. We aimed to dev…
View article: Evaluation of the potential impact and cost-effectiveness of respiratory syncytial virus (RSV) prevention strategies for infants in Argentina
Evaluation of the potential impact and cost-effectiveness of respiratory syncytial virus (RSV) prevention strategies for infants in Argentina Open
Either RSV mAb or maternal RSV vaccine are worth consideration in Argentina when priced at ≤US$ 50 per dose. A seasonal strategy could improve cost-effectiveness.
View article: Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis
Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis Open
Introduction There is lack of available data on the economic burden of wheezing episodes after severe respiratory syncytial virus (RSV) infection. This study aimed to assess the cost incurred for wheezing episodes after a severe RSV infect…
View article: Long-term healthcare utilisation, costs and quality of life after invasive group B <i>Streptococcus</i> disease: a cohort study in five low-income and middle-income countries
Long-term healthcare utilisation, costs and quality of life after invasive group B <i>Streptococcus</i> disease: a cohort study in five low-income and middle-income countries Open
Introduction There are no published data on the long-term impact of invasive group B Streptococcus disease (iGBS) on economic costs or health-related quality of life (HRQoL) in low-income and middle-income countries. We assessed the impact…
View article: Assessing the Long-Term Economic Impact of Wheezing Episodes After Severe RSV Disease in Children from Argentina: A Cost of Illness Analysis
Assessing the Long-Term Economic Impact of Wheezing Episodes After Severe RSV Disease in Children from Argentina: A Cost of Illness Analysis Open
Introduction There is a lack of available data on the economic burden of wheezing episodes resulting from prior severe respiratory syncytial virus (RSV) infections in resource-constrained settings. This study aimed to assess the cost incur…
View article: Cost of illness due to respiratory syncytial virus acute lower respiratory tract infection among infants hospitalized in Argentina
Cost of illness due to respiratory syncytial virus acute lower respiratory tract infection among infants hospitalized in Argentina Open
Background Information is scarce regarding the economic burden of respiratory syncytial virus (RSV) disease in low-resource settings. This study aimed to estimate the cost per episode of hospital admissions due to RSV severe disease in Arg…
View article: Cost of illness due to Respiratory Syncytial Virus Acute Lower Respiratory Tract Infection Among Infants Hospitalized in Argentina
Cost of illness due to Respiratory Syncytial Virus Acute Lower Respiratory Tract Infection Among Infants Hospitalized in Argentina Open
Background. Information is scarce regarding the economic burden of respiratory syncytial virus (RSV) disease in low-resource settings. This study aimed to estimate the cost per episode of hospital admissions due to RSV severe disease in Ar…
View article: Coronavirus Disease 2019 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-Analysis of Individual Participant Data From 5 Randomized Trials
Coronavirus Disease 2019 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-Analysis of Individual Participant Data From 5 Randomized Trials Open
Background Outpatient monoclonal antibodies are no longer effective and antiviral treatments for coronavirus disease 2019 (COVID-19) disease remain largely unavailable in many countries worldwide. Although treatment with COVID-19 convalesc…
View article: Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm: Methodology and applications
Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm: Methodology and applications Open
This data set could identify an improved specific, sensitive set of criteria for diagnosing clinical pneumonia and help identify sick children in need of referral to a higher level of care or a change of therapy. Field studies could be des…
View article: COVID-19 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-analysis of Individual Participant Data From Five Randomized Trials
COVID-19 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-analysis of Individual Participant Data From Five Randomized Trials Open
Background Monoclonal antibody and antiviral treatments for COVID-19 disease remain largely unavailable worldwide, and existing monoclonal antibodies may be less active against circulating omicron variants. Although treatment with COVID-19…
View article: Asymptomatic COVID-19 in the elderly: dementia and viral clearance as risk factors for disease progression.
Asymptomatic COVID-19 in the elderly: dementia and viral clearance as risk factors for disease progression. Open
Background: SARS-CoV-2 infected individuals ≥60 years old have the highest hospitalization rates and represent >80% fatalities. Within this population, those in long-term facilities represent >50% of the total COVID-19 related deaths per c…
View article: Fatal enhanced respiratory syncytial virus disease in toddlers
Fatal enhanced respiratory syncytial virus disease in toddlers Open
Fatal enhanced respiratory syncytial virus disease in toddlers has distinctive immune and transcriptional features.
View article: Emotional and Behavioral Outcomes in Childhood for Survivors of Invasive Group B <i>Streptococcus</i> Disease in Infancy: Findings From 5 Low- and Middle-Income Countries
Emotional and Behavioral Outcomes in Childhood for Survivors of Invasive Group B <i>Streptococcus</i> Disease in Infancy: Findings From 5 Low- and Middle-Income Countries Open
Background Survivors of invasive group B Streptococcus (iGBS) disease, notably meningitis, are at increased risk of neurodevelopmental impairment. However, the limited studies to date have a median follow-up to 18 months and have mainly fo…
View article: Asymptomatic COVID-19 in the elderly: dementia and viral clearance as risk factors for disease progression.
Asymptomatic COVID-19 in the elderly: dementia and viral clearance as risk factors for disease progression. Open
Background: SARS-CoV-2 infected individuals ≥60 years old have the highest hospitalization rates and represent >80% fatalities. Within this population, those in long-term facilities represent >50% of the total COVID-19 related deaths per c…
View article: Quantifying long-term health and economic outcomes for survivors of group B Streptococcus invasive disease in infancy: protocol of a multi-country study in Argentina, India, Kenya, Mozambique and South Africa
Quantifying long-term health and economic outcomes for survivors of group B Streptococcus invasive disease in infancy: protocol of a multi-country study in Argentina, India, Kenya, Mozambique and South Africa Open
Sepsis and meningitis due to invasive group B Streptococcus (iGBS) disease during early infancy is a leading cause of child mortality. Recent systematic estimates of the worldwide burden of GBS suggested that there are 319,000 cases of inf…
View article: Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults
Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults Open
Early administration of high-titer convalescent plasma against SARS-CoV-2 to mildly ill infected older adults reduced the progression of Covid-19. (Funded by the Bill and Melinda Gates Foundation and the Fundación INFANT Pandemic Fund; Dir…
View article: “Asymptomatic COVID-19 in the elderly: dementia and viral clearance as risk factors for disease progression”. SAS Dataset
“Asymptomatic COVID-19 in the elderly: dementia and viral clearance as risk factors for disease progression”. SAS Dataset Open
This file contains the SAS dataset of the submitted article: “Asymptomatic COVID-19 in the elderly: dementia and viral clearance as risk factors for disease progression”.
View article: Prevention of severe COVID-19 in the elderly by early high-titer plasma
Prevention of severe COVID-19 in the elderly by early high-titer plasma Open
Background Therapies to interrupt progression of early COVID-19 remain elusive. Among them, convalescent plasma in hospitalized patients was unsuccessful, perhaps because antibody should be administered earlier. We advanced plasma infusion…
View article: Quantifying long-term health and economic outcomes for survivors of group B Streptococcus invasive disease in infancy: protocol of a multi-country study in Argentina, India, Kenya, Mozambique and South Africa
Quantifying long-term health and economic outcomes for survivors of group B Streptococcus invasive disease in infancy: protocol of a multi-country study in Argentina, India, Kenya, Mozambique and South Africa Open
Sepsis and meningitis due to invasive group B Streptococcus (iGBS) disease during early infancy is a leading cause of child mortality. Recent systematic estimates of the worldwide burden of GBS suggested that there are 319,000 cases of inf…
View article: Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants
Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants Open
RSV F protein nanoparticle vaccination in pregnant women did not meet the prespecified success criterion for efficacy against RSV-associated, medically significant lower respiratory tract infection in infants up to 90 days of life. The sug…
View article: Respiratory Failure and Death in Vulnerable Premature Children With Lower Respiratory Tract Illness
Respiratory Failure and Death in Vulnerable Premature Children With Lower Respiratory Tract Illness Open
Background Efforts to better understand the risk factors associated with respiratory failure (RF) and fatal lower respiratory tract infection (LRTI) in premature children in developing countries are necessary to elaborate evidenced-based p…
View article: Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children
Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children Open
Background Severity of human metapneumovirus (hMPV) lower respiratory illness (LRTI) is considered similar to that observed for respiratory syncytial virus (RSV). However, differences in severity between these pathogens have been noted, su…
View article: Effect of Concomitant Antibiotic and Vaccine Administration on Serologic Responses to Rotavirus Vaccine
Effect of Concomitant Antibiotic and Vaccine Administration on Serologic Responses to Rotavirus Vaccine Open
Data from 1174 infants enrolled in a previous rotavirus vaccine study were analyzed to determine the effect of antibiotic exposure (from 14 days before to 7 days after vaccination) on rotavirus serum immunoglobulin A (IgA) responses. Serum…
Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection Open
Background The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. Methods We conducted a one-stage individual participant data (IPD) meta-analysis exploring the ass…