Rommel G. Tirona
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View article: A.1 Repurposing Ambroxol as a disease-modifying treatment for Parkinson’s disease dementia: A phase 2, randomized, double blind placebo-controlled trial
A.1 Repurposing Ambroxol as a disease-modifying treatment for Parkinson’s disease dementia: A phase 2, randomized, double blind placebo-controlled trial Open
Background: Currently there are no disease modifying treatment for Synucleinopathies including Parkinson’s disease Dementia (PDD). Carrying a mutation in the GBA gene (beta-glucocerebrosidase/ GCAse) is a leading risk factor for synucleino…
View article: Issue Information
Issue Information Open
Clinical and Translational Science highlights original research that helps bridge laboratory discovery with the diagnosis and treatment of human disease.Research may appear as Articles, Commentaries, Point-Counterpoint, Phase Forwards, Rev…
View article: Expression and localization of efflux drug transporters P-glycoprotein and breast cancer resistance protein (BCRP) in adult human pancreatic islet alpha and beta cells
Expression and localization of efflux drug transporters P-glycoprotein and breast cancer resistance protein (BCRP) in adult human pancreatic islet alpha and beta cells Open
P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) are clinically important efflux transporters of the ATP-binding cassette (ABC) family of transporters, widely recognized for their broad substrate specificity …
View article: Investigation of <i>N</i>,<i>N</i>,<i>N</i>-Trimethyl-L-alanyl-L-proline Betaine (TMAP) as a Biomarker of Kidney Function
Investigation of <i>N</i>,<i>N</i>,<i>N</i>-Trimethyl-L-alanyl-L-proline Betaine (TMAP) as a Biomarker of Kidney Function Open
Glomerular filtration rate (GFR) is the most widely used tool for the measurement of kidney function, but endogenous biomarkers such as cystatin C and creatinine have limitations. A previous metabolomic study revealed N,N,…
View article: Data from Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance
Data from Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance Open
The antimicrotubular agent docetaxel is a widely used chemotherapeutic drug for the treatment of multiple solid tumors and is predominantly dependent on hepatic disposition. In this study, we evaluated drug uptake transporters capable of t…
View article: Supplementary Table 2 from Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance
Supplementary Table 2 from Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance Open
SLCO1B3 Variants
View article: Supplementary Table 1 from Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance
Supplementary Table 1 from Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance Open
SLCO1B1 Variants
View article: Data from Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance
Data from Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance Open
The antimicrotubular agent docetaxel is a widely used chemotherapeutic drug for the treatment of multiple solid tumors and is predominantly dependent on hepatic disposition. In this study, we evaluated drug uptake transporters capable of t…
View article: Supplementary Table 1 from Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance
Supplementary Table 1 from Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance Open
SLCO1B1 Variants
View article: Supplementary Table 2 from Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance
Supplementary Table 2 from Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance Open
SLCO1B3 Variants
View article: Thiopurine Methyltransferase Intermediate Metabolizer Status and Thiopurine‐Associated Toxicity During Maintenance Therapy in Childhood Acute Lymphoblastic Leukemia
Thiopurine Methyltransferase Intermediate Metabolizer Status and Thiopurine‐Associated Toxicity During Maintenance Therapy in Childhood Acute Lymphoblastic Leukemia Open
Mercaptopurine is a cornerstone of maintenance chemotherapy in childhood acute lymphoblastic leukemia (ALL). Its cytotoxic effects are mediated by 6‐thioguanine nucleotides (TGNs) incorporation into lymphocyte DNA. Thiopurine methyltransfe…
View article: Medication Prescribed Within One Year Preceding Fall-Related Injuries in Ontario Older Adults
Medication Prescribed Within One Year Preceding Fall-Related Injuries in Ontario Older Adults Open
Background Serious injuries secondary to falls are becoming more prevalent due to the worldwide ageing of societies. Several medication classes have been associated with falls and fall-related injuries. The purpose of this study was to des…
View article: Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters
Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters Open
View article: Cyclosporine as a novel treatment for amatoxin-containing mushroom poisoning: a case series
Cyclosporine as a novel treatment for amatoxin-containing mushroom poisoning: a case series Open
Ingestion of amatoxin-containing mushrooms can lead to fulminant hepatotoxicity and death. Despite recent interest in therapeutic options for amatoxin-exposed patients, there is no single, recommended treatment for amatoxin poisoning. Alph…
View article: Fall-related Injuries in Older Adults and Medications Prescribed within 30 Days Prior to the Injury
Fall-related Injuries in Older Adults and Medications Prescribed within 30 Days Prior to the Injury Open
Fall-related injuries in older adults have serious consequences both for individuals and the public health care system. The purpose of this study was to identify medication classes prescribed within 30 days prior to the injury that were as…
View article: Organic Anion Transporting Polypeptide 2B1 (OATP2B1) Genetic Variants: In Vitro Functional Characterization and Association With Circulating Concentrations of Endogenous Substrates
Organic Anion Transporting Polypeptide 2B1 (OATP2B1) Genetic Variants: In Vitro Functional Characterization and Association With Circulating Concentrations of Endogenous Substrates Open
Organic anion transporting polypeptide 2B1 (OATP2B1, gene SLCO2B1 ) is an uptake transporter that is thought to determine drug disposition and in particular, the oral absorption of medications. At present, the clinical relevance of SLCO2B1…
View article: Association of Sex With Stroke and Bleeding Risk of Apixaban and Rivaroxaban in Elderly Atrial Fibrillation Patients Using Propensity Score Weights
Association of Sex With Stroke and Bleeding Risk of Apixaban and Rivaroxaban in Elderly Atrial Fibrillation Patients Using Propensity Score Weights Open
Our findings do not suggest an association of sex with the 90-day risk of hemorrhage or ischemic stroke in older AF patients prescribed apixaban or rivaroxaban.
View article: Medication Review in Preventing Older Adults’ Fall-Related Injury: a Systematic Review & Meta-Analysis
Medication Review in Preventing Older Adults’ Fall-Related Injury: a Systematic Review & Meta-Analysis Open
Background
Medication review is essential in managing adverse drug reactions and improving drug safety in older adults. This systematic review evaluated medication review’s role as a single intervention or combined with other interventio…
View article: Medication Prescribed Within 1 Year Preceding Fall-Related Injuries in Older Adults in Ontario, Canada
Medication Prescribed Within 1 Year Preceding Fall-Related Injuries in Older Adults in Ontario, Canada Open
Background: The consequences of fall-related injuries are becoming more significant due to ageing societies worldwide. This study aims to provide information on medications prescribed to older adults within one year before they experienced…
View article: Adrenal Cushing Syndrome Diagnosed During Pregnancy: Successful Medical Management With Metyrapone
Adrenal Cushing Syndrome Diagnosed During Pregnancy: Successful Medical Management With Metyrapone Open
Adrenal Cushing syndrome during pregnancy is rare, and there is limited information on the effect and safety of metyrapone treatment both for mother and fetus. We present a 24-year-old woman diagnosed with adrenal Cushing syndrome at the e…
View article: Drug interactions and pharmacogenetic factors contribute to variation in apixaban concentration in atrial fibrillation patients in routine care
Drug interactions and pharmacogenetic factors contribute to variation in apixaban concentration in atrial fibrillation patients in routine care Open
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature's AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or …
View article: Targeted next generation sequencing as a tool for precision medicine
Targeted next generation sequencing as a tool for precision medicine Open
View article: Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1
Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1 Open
View article: Heating Injection Drug Preparation Equipment Used for Opioid Injection May Reduce HIV Transmission Associated With Sharing Equipment
Heating Injection Drug Preparation Equipment Used for Opioid Injection May Reduce HIV Transmission Associated With Sharing Equipment Open
Background: London, Canada, experienced an HIV outbreak among persons who inject drugs despite widespread distribution of harm reduction equipment. Hydromorphone controlled-release (HMC) is the local opioid of choice. Injection drug prepar…
View article: A196 A COMPARISON OF LIVER FIBROSIS AND SIMPLE STEATOSIS ASSESSMENT USING GADOXETIC-ACID ENHANCED MRI WITH MR ELASTOGRAPHY AND MRI FAT FRACTION
A196 A COMPARISON OF LIVER FIBROSIS AND SIMPLE STEATOSIS ASSESSMENT USING GADOXETIC-ACID ENHANCED MRI WITH MR ELASTOGRAPHY AND MRI FAT FRACTION Open
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has become a pandemic, affecting up to 25% of the global population, with high incidence and prevalence in North America.(1) The spectrum of disease ranges from simple steatosis to stea…
View article: Ambroxol as a novel disease-modifying treatment for Parkinson’s disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial
Ambroxol as a novel disease-modifying treatment for Parkinson’s disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial Open
View article: Additional file 1: of Targeted next generation sequencing as a tool for precision medicine
Additional file 1: of Targeted next generation sequencing as a tool for precision medicine Open
Table S1. Genomic coordinates of PGxSeq capture probe design. Table S2. Known promoter and intronic SNVs targeted in PGxSeq panel. Table S3. Polymerase chain reaction conditions and primers used for Sanger sequencing of rare NGS variants. …
View article: MEDICATION REVIEW IN PREVENTING FALL-RELATED INJURIES IN OLDER ADULTS-A SYSTEMATIC REVIEW AND META-ANALYSIS
MEDICATION REVIEW IN PREVENTING FALL-RELATED INJURIES IN OLDER ADULTS-A SYSTEMATIC REVIEW AND META-ANALYSIS Open
BACKGROUND: Medication use is considered a modifiable risk factor for falls and fall-related injuries in older adults. Hence, medication review is essential in managing adverse drug reactions, facilitating appropriate prescribing and impro…
View article: A phase 1 trial evaluating thioridazine in combination with cytarabine in patients with acute myeloid leukemia
A phase 1 trial evaluating thioridazine in combination with cytarabine in patients with acute myeloid leukemia Open
Key Points Intermediate-dose cytarabine can be safely combined with TDZ at 50 mg every 6 hours in older patients with relapsed or refractory AML. A 5-day monotherapy with TDZ led to reduced blast counts in 5 out of 11 patients and was asso…
View article: Thyroid Hormones Are Transport Substrates and Transcriptional Regulators of Organic Anion Transporting Polypeptide 2B1
Thyroid Hormones Are Transport Substrates and Transcriptional Regulators of Organic Anion Transporting Polypeptide 2B1 Open
Levothyroxine replacement therapy forms the cornerstone of hypothyroidism management. Variability in levothyroxine oral absorption may contribute to the well-recognized large interpatient differences in required dose. Moreover, levothyroxi…