Ron Hadas
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View article: Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification
Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification Open
The first lineage allocation in mouse and human embryos separates the inner cell mass (ICM) from the outer trophectoderm (TE). This symmetry-breaking event is executed through polarization of cells at the 8 cell stage and subsequent asymme…
View article: Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification
Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification Open
The first lineage allocation in mouse and human embryos separates the inner cell mass (ICM) from the outer trophectoderm (TE). This symmetry breaking event is executed through polarization of cells at the 8-cell stage and subsequent asymme…
View article: Genome-wide chromatin recording resolves dynamic cell state changes
Genome-wide chromatin recording resolves dynamic cell state changes Open
Understanding how the chromatin state of a cell influences its future behavior is a major challenge throughout biology. However, most chromatin profiling methods are limited to endpoint assays. Here, we present LagTag, a method for recover…
View article: Pathway Sculptor for Compact and Versatile Combinatorial Genetic Perturbation
Pathway Sculptor for Compact and Versatile Combinatorial Genetic Perturbation Open
The ability to perturb multiple proteins simultaneously within the same cell is essential for understanding and re-engineering biological pathways. CRISPR-Cas12a mutants with inactivated DNAse but intact RNAse activity (dCas12a) retain the…
View article: Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification
Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification Open
The first lineage allocation in mouse and human embryos separates the inner cell mass (ICM) from the outer trophectoderm (TE). This symmetry breaking event is executed through polarization of cells at the 8-cell stage and subsequent asymme…
View article: Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification
Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification Open
The first lineage allocation in mouse and human embryos separates the inner cell mass (ICM) from the outer trophectoderm (TE). This symmetry-breaking event is executed through polarization of cells at the 8 cell stage and subsequent asymme…
View article: Enhancing uterine receptivity for embryo implantation through controlled collagenase intervention
Enhancing uterine receptivity for embryo implantation through controlled collagenase intervention Open
Ineffective endometrial matrix remodeling, a key factor in infertility, impedes embryo implantation in the uterine wall. Our study reveals the cellular and molecular impact of human collagenase-1 administration in mouse uteri, demonstratin…
View article: Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification
Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification Open
The first lineage allocation in mouse and human embryos separates the inner cell mass (ICM) from the outer trophectoderm (TE). This symmetry breaking event is executed through polarization of cells at the 8-cell stage and subsequent asymme…
View article: Time-aligned hourglass gastrulation models in rabbit and mouse
Time-aligned hourglass gastrulation models in rabbit and mouse Open
The hourglass model describes the convergence of species within the same phylum to a similar body plan during development; however, the molecular mechanisms underlying this phenomenon in mammals remain poorly described. Here, we compare ra…
View article: Time-Aligned Hourglass Gastrulation Models in Rabbit and Mouse
Time-Aligned Hourglass Gastrulation Models in Rabbit and Mouse Open
The hourglass model describes the convergence of species within the same phylum to a similar body plan during development, yet the molecular mechanisms underlying this phenomenon in mammals remain poorly described. Here, we compare rabbit …
View article: Fyn and argonaute 2 participate in maternal-mRNA degradation during mouse oocyte maturation
Fyn and argonaute 2 participate in maternal-mRNA degradation during mouse oocyte maturation Open
Fertilization triggers physiological degradation of maternal-mRNAs, which are then replaced by embryonic transcripts. Ample evidence suggests that Argonaut 2 (AGO2) is a possible post-fertilization regulator of maternal-mRNAs degradation; …
View article: Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells
Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells Open
Successful implantation is associated with a unique spatial pattern of vascular remodeling, characterized by profound peripheral neovascularization surrounding a periembryo avascular niche. We hypothesized that hyaluronan controls the form…
View article: Diffusion and perfusion MRI of normal, preeclamptic and growth-restricted mice models reveal clear fetoplacental differences
Diffusion and perfusion MRI of normal, preeclamptic and growth-restricted mice models reveal clear fetoplacental differences Open
Diffusion-weighted MRI on rodents could be valuable to evaluate pregnancy-related dysfunctions, particularly in knockout models whose biological nature is well understood. Echo Planar Imaging’s sensitivity to motions and to air/water/fat h…
View article: Production of Hyaluronan by the Trophectoderm is a Prerequisite for Mouse Blastocyst Attachment
Production of Hyaluronan by the Trophectoderm is a Prerequisite for Mouse Blastocyst Attachment Open
Embryo implantation requires execution of highly synchronized processes at the feto-maternal interface, initiated by blastocyst attachment to the endometrial epithelium. Hyaluronan is a major ECM component known to regulate adhesion-associ…
View article: Hyaluronan-NK cell Interaction Controls the Primary Vascular Barrier during Early Pregnancy
Hyaluronan-NK cell Interaction Controls the Primary Vascular Barrier during Early Pregnancy Open
Successful implantation is associated with a unique spatial pattern of vascular remodeling, characterized by profound peripheral neo-vascularization surrounding a peri-embryo avascular niche. We hypothesized that hyaluronan controls the fo…
View article: Magnetic Resonance Imaging Reveals Distinct Roles for Tissue Transglutaminase and Factor XIII in Maternal Angiogenesis During Early Mouse Pregnancy
Magnetic Resonance Imaging Reveals Distinct Roles for Tissue Transglutaminase and Factor XIII in Maternal Angiogenesis During Early Mouse Pregnancy Open
Objective: The early embryo implantation is characterized by enhanced uterine vascular permeability at the site of blastocyst attachment, followed by extracellular-matrix remodeling and angiogenesis. Two TG (transglutaminase) isoenzymes, T…
View article: Identification of Trophectoderm-Derived Cripto as an Essential Mediator of Embryo Implantation
Identification of Trophectoderm-Derived Cripto as an Essential Mediator of Embryo Implantation Open
Cripto-1 (TDGF1) is a multifunctional signaling factor that stimulates cellular effects, including proliferation, migration, survival, epithelial-to-mesenchymal transition, and angiogenesis, to regulate embryogenesis, tissue homeostasis, a…
View article: Placental physiology monitored by hyperpolarized dynamic <sup>13</sup> C magnetic resonance
Placental physiology monitored by hyperpolarized dynamic <sup>13</sup> C magnetic resonance Open
Significance The placenta mediates the transfer of metabolites and nutrients, and its dysfunction leads to clinical syndromes that jeopardize both the fetus and mother. Current methods for assessing placental transport and metabolism in vi…
View article: Carryover Effects of Acute DEHP Exposure on Ovarian Function and Oocyte Developmental Competence in Lactating Cows
Carryover Effects of Acute DEHP Exposure on Ovarian Function and Oocyte Developmental Competence in Lactating Cows Open
We examined acute exposure of Holstein cows to di(2-ethylhexyl) phthalate (DEHP) and its carryover effects on ovarian function and oocyte developmental competence. Synchronized cows were tube-fed with water or 100 mg/kg DEHP per day for 3 …