Ron M. C. Herings
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View article: Type 2 diabetes monitoring and control in migrants and non-migrants: A population-based cohort study in primary care in the Netherlands
Type 2 diabetes monitoring and control in migrants and non-migrants: A population-based cohort study in primary care in the Netherlands Open
Most migrant groups were equally or better monitored for T2D-parameters compared to non-migrants, but were less likely to meet HbA1c targets. This might partly reflect the less frequent insulin prescriptions to migrants. Further research i…
View article: Feasibility of implementing an intervention in general practice for deprescribing of glucose-lowering medication in overtreated elderly
Feasibility of implementing an intervention in general practice for deprescribing of glucose-lowering medication in overtreated elderly Open
Background Elderly patients with Type 2 diabetes (T2D) are frequently overtreated with glucose-lowering medication. Objective This feasibility study evaluated the implementation of a deprescribing programme (DPP) for general practices, con…
View article: Rates of SARS-CoV-2 Breakthrough Infection or Severe COVID-19 and Associated Risk Factors After Primary and Booster Vaccination Against COVID-19 in the Netherlands
Rates of SARS-CoV-2 Breakthrough Infection or Severe COVID-19 and Associated Risk Factors After Primary and Booster Vaccination Against COVID-19 in the Netherlands Open
Background: The effectiveness of COVID-19 vaccines appears to decline rapidly over time due to waning immunity and immune evasion by emerging variants of concern, and may be reduced in high-risk populations. We aimed to evaluate the rates …
View article: Clinical Profile and Treatment Patterns in Individuals with Type 2 Diabetes and Chronic Kidney Disease Who Initiate a GLP-1 Receptor Agonist: A Multinational Cohort Study
Clinical Profile and Treatment Patterns in Individuals with Type 2 Diabetes and Chronic Kidney Disease Who Initiate a GLP-1 Receptor Agonist: A Multinational Cohort Study Open
View article: Identifying a cohort of hospitalized chronic kidney disease patients using electronic health records: lessons learnt and implications for future research and clinical practice guidelines
Identifying a cohort of hospitalized chronic kidney disease patients using electronic health records: lessons learnt and implications for future research and clinical practice guidelines Open
Background Safe medication prescribing for hospitalized chronic kidney disease (CKD) patients is challenging. Leveraging electronic health records (EHRs) offers potential for decision support. A first step is to capture the CKD cohort thro…
View article: Clinical Profile and Treatment Adherence in Patients with Type 2 Diabetes and Chronic Kidney Disease Who Initiate an SGLT2 Inhibitor: A Multi-cohort Study
Clinical Profile and Treatment Adherence in Patients with Type 2 Diabetes and Chronic Kidney Disease Who Initiate an SGLT2 Inhibitor: A Multi-cohort Study Open
View article: Cognitive symptoms and medical history prior to mild cognitive impairment and dementia diagnosis: a retrospective case‐control study using Dutch primary care data
Cognitive symptoms and medical history prior to mild cognitive impairment and dementia diagnosis: a retrospective case‐control study using Dutch primary care data Open
Background General practitioners (GPs) play a crucial role in recognizing cognitive deficits and diagnosing dementia. Currently, dementia diagnosis in primary care is prone to be missed or delayed. Electronic health records from GPs can of…
View article: Women have a higher risk of hospital admission associated with hyponatremia than men while using diuretics
Women have a higher risk of hospital admission associated with hyponatremia than men while using diuretics Open
Background Hyponatremia is a common electrolyte disturbance and known adverse drug reaction of diuretics. Women tend to be more susceptible for diuretic associated hyponatremia. The aim of this study was to find more evidence whether women…
View article: A deprescribing programme aimed to optimise blood glucose-lowering medication in older people with type 2 diabetes mellitus, the OMED2-study: the study protocol for a randomised controlled trial
A deprescribing programme aimed to optimise blood glucose-lowering medication in older people with type 2 diabetes mellitus, the OMED2-study: the study protocol for a randomised controlled trial Open
View article: Safety profile of rivaroxaban in first-time users treated for venous thromboembolism in four European countries
Safety profile of rivaroxaban in first-time users treated for venous thromboembolism in four European countries Open
Background The European rivaroxaban post-authorization safety study evaluated bleeding risk among patients initiated on rivaroxaban or vitamin K antagonists for the treatment and secondary prevention of venous thromboembolism in routine cl…
View article: Type 2 Diabetes, the Epidemic: Trends in Prevalence and Incidence, 2004-2020
Type 2 Diabetes, the Epidemic: Trends in Prevalence and Incidence, 2004-2020 Open
From 2004-2020, the prevalence of T2D in the Netherlands more than doubled, with a decreasing incidence from 2010 onwards.
View article: Challenges and lessons learned from a long-term postauthorisation safety study programme of rivaroxaban in Europe
Challenges and lessons learned from a long-term postauthorisation safety study programme of rivaroxaban in Europe Open
Objectives To describe opportunities and challenges experienced from the four pharmacoepidemiological database studies included in the rivaroxaban post authorisation safety study (PASS) programme and propose ways to maximise the value of p…
View article: Using real‐world general practitioner data to study the diagnosis and management of dementia: rationale and design
Using real‐world general practitioner data to study the diagnosis and management of dementia: rationale and design Open
Background General practitioners (GPs) play a critical role in the early recognition of cognitive deficits and management of dementia. Timely diagnosis is important in light of potential disease‐modifying therapies and the potential to imp…
View article: Risk of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: results from the EXACOS-CV cohort study using the PHARMO Data Network in the Netherlands
Risk of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: results from the EXACOS-CV cohort study using the PHARMO Data Network in the Netherlands Open
View article: The Impact of the COVID-19 Pandemic in The Netherlands on Primary Healthcare Use and Clinical Outcomes in Persons with Type 2 Diabetes
The Impact of the COVID-19 Pandemic in The Netherlands on Primary Healthcare Use and Clinical Outcomes in Persons with Type 2 Diabetes Open
The COVID-19 pandemic has had a significant impact on healthcare systems worldwide, including the postponing or canceling of appointments and procedures for type 2 diabetes (T2D) care by general practitioners (GPs) in the Netherlands. The …
View article: Impact of implementing Dutch versus European guideline risk factor targets in older patients with ischaemic heart disease
Impact of implementing Dutch versus European guideline risk factor targets in older patients with ischaemic heart disease Open
Background In patients with ischaemic heart disease (IHD) aged > 70 years, Dutch and European guidelines recommend different treatment targets: low-density lipoprotein cholesterol (LDL-c) < 2.6 versus < 1.4 mmol/l and systolic blood pressu…
View article: Impact of EU Label Changes and Revised Pregnancy Prevention Programme for Oral Retinoid-Containing Medicinal Products: acitretin, alitretinoin and isotretinoin
Impact of EU Label Changes and Revised Pregnancy Prevention Programme for Oral Retinoid-Containing Medicinal Products: acitretin, alitretinoin and isotretinoin Open
This report describes a pharmaco-epidemiological study using longitudinal data collected in six electronic health care databases from 4 European Union (EU) countries to investigate the use of oral retinoid-containing medicinal products aut…
View article: Impact of the 2018 revised Pregnancy Prevention Programme by the European Medicines Agency on the use of oral retinoids in females of childbearing age in Denmark, Italy, Netherlands, and Spain: an interrupted time series analysis
Impact of the 2018 revised Pregnancy Prevention Programme by the European Medicines Agency on the use of oral retinoids in females of childbearing age in Denmark, Italy, Netherlands, and Spain: an interrupted time series analysis Open
Background: In March 2018, the European pregnancy prevention programme for oral retinoids was updated as part of risk minimisation measures (RMM), emphasising their contraindication in pregnant women. Objective: To measure the impact of th…
View article: Identification of frailty in primary care: accuracy of electronically derived measures
Identification of frailty in primary care: accuracy of electronically derived measures Open
Background Routinely collected clinical data based on electronic medical records could be used to define frailty. Aim To estimate the ability of four potential frailty measures that use electronic medical record data to identify older pati…
View article: Safety profile of rivaroxaban in first-time users treated for venous thromboembolism (deep vein thrombosis and pulmonary embolism) in four European countries
Safety profile of rivaroxaban in first-time users treated for venous thromboembolism (deep vein thrombosis and pulmonary embolism) in four European countries Open
Background The European rivaroxaban post-authorization safety study evaluated bleeding risk among patients initiated on rivaroxaban or vitamin K antagonists for the treatment and secondary prevention of venous thromboembolism in routine cl…
View article: A study protocol of external validation of eight COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting
A study protocol of external validation of eight COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting Open
Background The COVID-19 pandemic has a large impact worldwide and is known to particularly affect the older population. This paper outlines the protocol for external validation of prognostic models predicting mortality risk after presentat…
View article: Incidence of Lyme Borreliosis in the Dutch General Practice Population: A Large-Scale Population-Based Cohort Study Across the Netherlands Between 2015 and 2019
Incidence of Lyme Borreliosis in the Dutch General Practice Population: A Large-Scale Population-Based Cohort Study Across the Netherlands Between 2015 and 2019 Open
Background: There is a need for updated incidence rates (IRs) of Lyme borreliosis (LB) in Europe, including the Netherlands. We estimated LB IRs stratified by geographic area, year, age, sex, immunocompromised status, and soc…
View article: Safety and effectiveness of rivaroxaban for prevention of stroke in patients with nonvalvular atrial fibrillation: analysis of routine clinical data from four countries
Safety and effectiveness of rivaroxaban for prevention of stroke in patients with nonvalvular atrial fibrillation: analysis of routine clinical data from four countries Open
Incidences of intracranial bleeding were generally lower with rivaroxaban than with SOC, whereas incidences of gastrointestinal and urogenital bleeding were generally higher. The safety profile of rivaroxaban for NVAF in routine practice i…
View article: Methodology of the brodalumab assessment of hazards: a multicentre observational safety (BRAHMS) study
Methodology of the brodalumab assessment of hazards: a multicentre observational safety (BRAHMS) study Open
Introduction Safe and effective pharmacological treatment is of paramount importance for treating severe psoriasis. Brodalumab, a monoclonal antibody against interleukin (IL) 17 receptor A, was granted marketing authorisation in the EU in …
View article: Time Trends in Patient Characteristics of New Rivaroxaban Users with Atrial Fibrillation in Germany and the Netherlands
Time Trends in Patient Characteristics of New Rivaroxaban Users with Atrial Fibrillation in Germany and the Netherlands Open
View article: Women on diuretics have a higher risk of hospital admission because of hyponatremia than men
Women on diuretics have a higher risk of hospital admission because of hyponatremia than men Open
Purpose Recent studies suggest that women are more susceptible to diuretic‐induced hyponatremia resulting in hospital admission than men. The aim of this study was to confirm whether these sex differences in hyponatremia‐related hospital a…
View article: Completeness and Representativeness of the PHARMO General Practitioner (GP) Data: A Comparison with National Statistics
Completeness and Representativeness of the PHARMO General Practitioner (GP) Data: A Comparison with National Statistics Open
The PHARMO GP data are representative of the Dutch population with regard to the demographic characteristics and diagnoses in primary care. Medication data in the PHARMO GP data are more complete than national statistics, and differences a…
View article: Effectiveness of COVID-19 Vaccines in Adults with Diabetes Mellitus: A Systematic Review
Effectiveness of COVID-19 Vaccines in Adults with Diabetes Mellitus: A Systematic Review Open
Persons with diabetes mellitus may have an increased risk of severe illness or death from COVID-19 compared to persons without diabetes. Prior studies indicate that immune response and thus vaccine effectiveness might be lower in persons w…
View article: The DIAbetes MANagement and Treatment (DIAMANT) Cohort
The DIAbetes MANagement and Treatment (DIAMANT) Cohort Open
The DIAMANT cohort provides the opportunity to gain RWD insights into the treatment and outcomes among people with diabetes in daily general practice. The data can be enriched by established linkages to other data sources (eg, hospital dat…
View article: Myocarditis and pericarditis associated with SARS-CoV-2 vaccines: A population-based descriptive cohort and a nested self-controlled risk interval study using electronic health care data from four European countries
Myocarditis and pericarditis associated with SARS-CoV-2 vaccines: A population-based descriptive cohort and a nested self-controlled risk interval study using electronic health care data from four European countries Open
Background: Estimates of the association between COVID-19 vaccines and myo-/pericarditis risk vary widely across studies due to scarcity of events, especially in age- and sex-stratified analyses. Methods: Population-based cohort study with…