Ron M. Kagan
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View article: HIV-1 Drug Resistance Trends in the Era of Modern Antiretrovirals: 2018–2024
HIV-1 Drug Resistance Trends in the Era of Modern Antiretrovirals: 2018–2024 Open
Background Antiretroviral drug resistance limits treatment options for people with human immunodeficiency virus (HIV) 1 and may reduce the effectiveness of preexposure prophylaxis. Novel treatment options with enhanced efficacy and more co…
View article: Epidemiological Burden of Hepatitis Delta Virus in the United States
Epidemiological Burden of Hepatitis Delta Virus in the United States Open
Hepatitis D virus (HDV) affects nearly 5% of people globally who are chronically infected with hepatitis B virus, according to the World Health Organisation. The prevalence of HDV in the United States is considered lower than in other coun…
View article: Identification of Human Monkeypox Virus Genome Deletions That Impact Diagnostic Assays
Identification of Human Monkeypox Virus Genome Deletions That Impact Diagnostic Assays Open
In August 2022, the Los Angeles County Department of Public Health initiated an investigation into human monkeypox virus (MPXV) cases with unusual results from a multiplex laboratory-developed test used by Quest Diagnostics, which is based…
View article: Rapid and Accurate Identification of SARS-CoV-2 Variants Using Real Time PCR Assays
Rapid and Accurate Identification of SARS-CoV-2 Variants Using Real Time PCR Assays Open
Background Genomic surveillance efforts for SARS-CoV-2 are needed to understand the epidemiology of the COVID-19 pandemic. Viral variants may impact routine diagnostic testing, increase viral transmissibility, cause differences in disease …
View article: Development and Validation of a High-Throughput Next-Generation Sequencing Workflow for SARS-CoV-2 Whole Genome Sequencing: Results from Over 65,000 Clinical Cases
Development and Validation of a High-Throughput Next-Generation Sequencing Workflow for SARS-CoV-2 Whole Genome Sequencing: Results from Over 65,000 Clinical Cases Open
Monitoring new mutations in SARS-CoV-2 provides crucial information for identifying diagnostic and therapeutic targets and important insights to achieve a more effective COVID-19 control strategy. Next generation sequencing (NGS) technolog…
View article: Performance of Unobserved Self-Collected Nasal Swabs for Detection of SARS-CoV-2 by RT-PCR Utilizing a Remote Specimen Collection Strategy
Performance of Unobserved Self-Collected Nasal Swabs for Detection of SARS-CoV-2 by RT-PCR Utilizing a Remote Specimen Collection Strategy Open
Background The use of a remote specimen collection strategy employing a kit designed for unobserved self-collection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) c…
View article: Pooling of Upper Respiratory Specimens Using a SARS-CoV-2 Real-time RT-PCR Assay Authorized for Emergency Use in Low-Prevalence Populations for High-Throughput Testing
Pooling of Upper Respiratory Specimens Using a SARS-CoV-2 Real-time RT-PCR Assay Authorized for Emergency Use in Low-Prevalence Populations for High-Throughput Testing Open
Background Nucleic acid amplification testing is a critical tool for addressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Specimen pooling can increase throughput and conserve testing resources but requires…
View article: Evaluation of Transport Media and Specimen Transport Conditions for the Detection of SARS-CoV-2 by Use of Real-Time Reverse Transcription-PCR
Evaluation of Transport Media and Specimen Transport Conditions for the Detection of SARS-CoV-2 by Use of Real-Time Reverse Transcription-PCR Open
The global coronavirus (CoV) disease 2019 (COVID-19) pandemic has resulted in a worldwide shortage of viral transport media and raised questions about specimen stability. The objective of this study was to determine the stability of severe…
View article: Detailed Transmission Network Analysis of a Large Opiate-Driven Outbreak of HIV Infection in the United States
Detailed Transmission Network Analysis of a Large Opiate-Driven Outbreak of HIV Infection in the United States Open
We demonstrate that integration of laboratory, phylogenetic, and epidemiologic data sources allow detailed reconstruction of an outbreak. High-resolution reconstruction of outbreak phylodynamics allows prevention and intervention strategie…
View article: Antiretroviral Drug Resistance Among Children and Youth in the United States With Perinatal HIV
Antiretroviral Drug Resistance Among Children and Youth in the United States With Perinatal HIV Open
Among 234 US youths with perinatal human immunodeficiency virus, 75% had antiretroviral resistance, substantially higher than that of the reference laboratory overall (36%-44%). Resistance to newer antiretrovirals and to all antiretroviral…